{"id":"coristina-d","safety":{"commonSideEffects":[{"rate":null,"effect":"Drowsiness"},{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Nervousness or insomnia"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL202011","moleculeType":"Small molecule","molecularWeight":"354.41"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The drug combines an antihistamine (likely chlorpheniramine or similar) to block H1 histamine receptors and reduce allergic symptoms such as itching and sneezing, with a decongestant (likely phenylephrine or pseudoephedrine) that acts as a sympathomimetic to constrict blood vessels in the nasal mucosa and reduce congestion. This dual mechanism provides symptomatic relief of both allergic and cold-related upper respiratory symptoms.","oneSentence":"Coristina D is a combination antihistamine and decongestant that reduces allergy and cold symptoms by blocking histamine receptors and constricting nasal blood vessels.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:07:39.219Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Symptomatic relief of allergic rhinitis"},{"name":"Symptomatic relief of common cold and upper respiratory congestion"}]},"trialDetails":[{"nctId":"NCT02735070","phase":"PHASE3","title":"Study Comparing Coristina® D to Resfenol® in the Symptomatic Treatment of Common Cold","status":"UNKNOWN","sponsor":"Brainfarma Industria Química e Farmacêutica S/A","startDate":"2016-09","conditions":"Cold","enrollment":366}],"_emaApprovals":[],"_faersSignals":[{"count":4,"reaction":"DIARRHOEA"},{"count":4,"reaction":"DRUG INEFFECTIVE"},{"count":3,"reaction":"MALAISE"},{"count":2,"reaction":"ACCIDENTAL EXPOSURE"},{"count":2,"reaction":"ARTERIAL OCCLUSIVE DISEASE"},{"count":2,"reaction":"ASTHENIA"},{"count":2,"reaction":"BLOOD GLUCOSE INCREASED"},{"count":2,"reaction":"DEPRESSION"},{"count":2,"reaction":"DIZZINESS"},{"count":2,"reaction":"INFLUENZA"}],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Coristina d","genericName":"Coristina d","companyName":"Brainfarma Industria Química e Farmacêutica S/A","companyId":"brainfarma-industria-qu-mica-e-farmac-utica-s-a","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Coristina D is a combination antihistamine and decongestant that reduces allergy and cold symptoms by blocking histamine receptors and constricting nasal blood vessels. Used for Symptomatic relief of allergic rhinitis, Symptomatic relief of common cold and upper respiratory congestion.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}