{"id":"cord-blood-infusion","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Graft-versus-host disease"},{"rate":"5-15%","effect":"Infection"},{"rate":"5-10%","effect":"Bleeding"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This process can help to treat various blood-related disorders by replenishing the recipient's bone marrow with healthy stem cells. The exact mechanism of action is not fully understood, but it is believed to involve the engraftment of the donor stem cells into the recipient's bone marrow, leading to the production of new blood cells.","oneSentence":"Cord blood infusion involves the transfer of hematopoietic stem cells from the umbilical cord to a recipient to stimulate the production of new blood cells.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:09:06.706Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of severe combined immunodeficiency (SCID)"},{"name":"Treatment of leukemia and lymphoma"},{"name":"Treatment of other blood-related disorders"}]},"trialDetails":[{"nctId":"NCT07444632","phase":"PHASE1","title":"Phase1 Basket Trial Of CAR.70-Engineered IL15-Transduced With TGFBR2 Knock Out Cord Blood-Derived NK Cells For Relapsed/Refractory Lymphoid Malignancies","status":"NOT_YET_RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2026-08-31","conditions":"Lymphoid, Hodgkin Lymphoma","enrollment":60},{"nctId":"NCT03173937","phase":"PHASE1, PHASE2","title":"Unrelated Umbilical Cord Blood Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS Using CordIn(TM), Umbilical Cord Blood-Derived Ex Vivo Expanded Stem and Progenitor Cells to Expedite Engraftment and Improve Transplant Outcome","status":"RECRUITING","sponsor":"National Heart, Lung, and Blood Institute (NHLBI)","startDate":"2017-06-13","conditions":"Severe Aplastic Anemia, Hypo-Plastic MDS, Myelodysplastic Syndrome (MDS)","enrollment":37},{"nctId":"NCT07492628","phase":"PHASE1","title":"Dual-Target Nectin-4/HER2 CAR-NK Cells in Advanced Urothelial Carcinoma","status":"RECRUITING","sponsor":"Beijing Biotech","startDate":"2026-03-02","conditions":"Bladder Cancer, Urothelial Carcinoma, Metastatic Urothelial Carcinoma","enrollment":42},{"nctId":"NCT05204290","phase":"EARLY_PHASE1","title":"Study of Combined Decompressive Spine Radiosurgery and Pembrolizumab","status":"TERMINATED","sponsor":"Wake Forest University Health Sciences","startDate":"2022-03-28","conditions":"Epidural Spinal Tumors, Cancer","enrollment":1},{"nctId":"NCT04990323","phase":"PHASE1, PHASE2","title":"US Study of ECT-001-CB in Pediatric and Young Adult Patients With High-Risk Myeloid Malignancies","status":"COMPLETED","sponsor":"ExCellThera inc.","startDate":"2021-12-01","conditions":"High Risk Myeloid Malignancies, Cord Blood Transplant","enrollment":13},{"nctId":"NCT01861106","phase":"PHASE2","title":"Allogeneic Hematopoietic Stem Cell Transplant for GATA2 Mutations","status":"RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2013-07-24","conditions":"GATA2, Immunodeficiency, MDS","enrollment":144},{"nctId":"NCT07332338","phase":"","title":"Expanded Access Use of Human Umbilical Cord Blood (REGENECYTE) Infusion in Patients With Chronic Fatigue of Post-COVID Condition","status":"AVAILABLE","sponsor":"StemCyte, Inc.","startDate":"","conditions":"Post-COVID-19 Condition, Post-COVID Condition, Post-COVID Syndrome","enrollment":""},{"nctId":"NCT04103879","phase":"PHASE2","title":"US Study of UM171-Expanded CB in Patients With High Risk Leukemia/Myelodysplasia","status":"COMPLETED","sponsor":"ExCellThera inc.","startDate":"2020-11-13","conditions":"High Risk Hematological Malignancy, Cord Blood Transplant","enrollment":30},{"nctId":"NCT07101432","phase":"PHASE1","title":"Phase I Study of Preconditioning Radiation Therapy With IL-15 Transduced TGFBR2 KO CAR.TROP2-engineered Cord Blood-derived NK Cells in Patients With Advanced Head and Neck Cancer (RADIANCE-NK)","status":"RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2025-11-04","conditions":"Head and Neck Cancer","enrollment":33},{"nctId":"NCT03684980","phase":"EARLY_PHASE1","title":"LTA Pilot Study of Glucarpidase in Patients With Central Nervous System Lymphoma","status":"ACTIVE_NOT_RECRUITING","sponsor":"Memorial Sloan Kettering Cancer Center","startDate":"2018-11-14","conditions":"Central Nervous System Lymphoma","enrollment":58},{"nctId":"NCT03441958","phase":"PHASE1, PHASE2","title":"ECT-001 (UM171) Expanded Cord Blood Transplant to Treat High-risk Multiple Myeloma","status":"COMPLETED","sponsor":"Ciusss de L'Est de l'Île de Montréal","startDate":"2018-03-07","conditions":"Multiple Myeloma","enrollment":19},{"nctId":"NCT04347616","phase":"PHASE1, PHASE2","title":"Natural Killer-cell Therapy for Acute Myeloid Leukemia","status":"TERMINATED","sponsor":"Radboud University Medical Center","startDate":"2020-12-03","conditions":"Acute Myeloid Leukemia Refractory, Acute Myeloid Leukemia, Relapsed, Adult","enrollment":9},{"nctId":"NCT04644016","phase":"PHASE2","title":"Cord Blood Transplant in Children and Young Adults With Blood Cancers and Non-malignant Disorders","status":"RECRUITING","sponsor":"Memorial Sloan Kettering Cancer Center","startDate":"2020-11-20","conditions":"AML, ALL, MDS","enrollment":31},{"nctId":"NCT07467863","phase":"PHASE1, PHASE2","title":"Dual-Target CAR-NK Cells Directed Against MSLN, EGFR, or HER2 in Advanced NSCLC","status":"RECRUITING","sponsor":"Beijing Biotech","startDate":"2026-02-02","conditions":"Non-Small Cell Lung Cancer, Advanced/Metastatic NSCLC","enrollment":48},{"nctId":"NCT01962636","phase":"NA","title":"Umbilical Cord Blood Transplantation Using a Myeloablative Preparative Regimen for Hematological Diseases","status":"RECRUITING","sponsor":"Masonic Cancer Center, University of Minnesota","startDate":"2016-12","conditions":"Acute Myeloid Leukemia (AML), Acute Lymphocytic Leukemia (ALL), Chronic Myelogenous Leukemia","enrollment":200},{"nctId":"NCT06930651","phase":"PHASE1, PHASE2","title":"A Phase I/II Study of CAR.70-Engineered IL15-Transduced Cord Blood-Derived NK Cells With TGF-beta Receptor 2 (TGFBR2) Knock Out in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapsed/Refractory Myeloid Malignancies","status":"RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2025-09-03","conditions":"Myeloid Malignancies","enrollment":42},{"nctId":"NCT07134712","phase":"PHASE2","title":"Safety and Efficacy of MiSaver (CB Cells) for Acute Myocardial Infarction, Phase II","status":"NOT_YET_RECRUITING","sponsor":"HONYA Medical Co Ltd","startDate":"2026-03-30","conditions":"Acute Myocardial Infarction (AMI)","enrollment":102},{"nctId":"NCT04565665","phase":"PHASE1, PHASE2","title":"Study of Cord Blood Derived Mesenchymal Stem Cells for Treatment of Moderate, Severe or Critical Pneumonia","status":"RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2020-07-29","conditions":"COVID-19 Infection, COVID-19-Associated Acute Respiratory Distress Syndrome, Hematopoietic and Lymphoid Cell Neoplasm","enrollment":70},{"nctId":"NCT07210411","phase":"NA","title":"Acute and Chronic Repercussion of Spinal Cord Stimulation After Spinal Cord Injury","status":"RECRUITING","sponsor":"Mayo Clinic","startDate":"2026-03-05","conditions":"Spinal Cord Injuries","enrollment":80},{"nctId":"NCT05703854","phase":"PHASE1, PHASE2","title":"Study of CAR.70-engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of Advanced Renal Cell Carcinoma, Mesothelioma and Osteosarcoma","status":"RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2023-03-29","conditions":"Advanced Renal Cell Carcinoma, Advanced Mesothelioma, Advanced Osteosarcoma","enrollment":50},{"nctId":"NCT06947473","phase":"PHASE1, PHASE2","title":"Umbilical Cord Blood CD19-BCMA CART Cell Therapy for SLE-LN, SSc, andpSS PAH.","status":"RECRUITING","sponsor":"Beijing GoBroad Hospital","startDate":"2026-03-18","conditions":"Refractory Lupus Nephritis, Systemic Sclerosis, Primary Sjogren's Syndrome Combined With Pulmonary Hypertension","enrollment":45},{"nctId":"NCT07441720","phase":"PHASE2","title":"Safety and Efficacy of Umbilical Cord Blood Therapy for Cancer Therapy-Induced Thrombocytopenia (CTIT)","status":"RECRUITING","sponsor":"Zhejiang Cancer Hospital","startDate":"2026-02-28","conditions":"Thrombocytopenia, Cancer Treatment-induced Thrombocytopenia","enrollment":25},{"nctId":"NCT02730299","phase":"PHASE3","title":"Stem Cell Transplantation With NiCord® (Omidubicel) vs Standard UCB in Patients With Leukemia, Lymphoma, and MDS","status":"COMPLETED","sponsor":"Gamida Cell ltd","startDate":"2016-12-16","conditions":"Hematological Malignancies, Acute Lymphoblastic Leukemia (ALL), Acute Myelogenous Leukemia (AML)","enrollment":125},{"nctId":"NCT07210437","phase":"NA","title":"Longitudinal Autonomic Characterization as a Predictor for Secondary Medical Complications Post-SCI","status":"RECRUITING","sponsor":"Mayo Clinic","startDate":"2026-01-31","conditions":"Spinal Cord Injuries","enrollment":18},{"nctId":"NCT07212335","phase":"EARLY_PHASE1","title":"Safety and Efficacy of Umbilical Cord Blood-Derived Mesenchymal Stem Cells in the Treatment of Long-Term Cytopenia After CAR-T Therapy","status":"RECRUITING","sponsor":"Institute of Hematology & Blood Diseases Hospital, China","startDate":"2025-10-01","conditions":"Immune Effector Cell Associated Hematotoxicity","enrollment":15},{"nctId":"NCT07304440","phase":"PHASE1, PHASE2","title":"Adia MED of Winter Park LLC Autism Spectrum Disorder Research Study","status":"RECRUITING","sponsor":"Adia Med of Winter Park LLC","startDate":"2026-01-12","conditions":"Autism Spectrum Disorder, Autism, ASD","enrollment":100},{"nctId":"NCT04493372","phase":"NA","title":"Deciphering Preserved Autonomic Function After Spinal Cord Injury","status":"RECRUITING","sponsor":"Mayo Clinic","startDate":"2020-11-13","conditions":"Spinal Cord Injuries, Autonomic Imbalance, Autonomic Dysreflexia","enrollment":69},{"nctId":"NCT07377526","phase":"PHASE1, PHASE2","title":"Phase 1/2 Study TROP2 CAREngineered Cord Blood-Derived NK Cells + Belzutifan In Pancreatic Cancer","status":"NOT_YET_RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2026-07-01","conditions":"Pancreatic Cancer","enrollment":37},{"nctId":"NCT06464965","phase":"PHASE1","title":"Clinical Study of Cord Blood-Derived CAR-NK Cells in Gastric Cancer and Pancreatic Cancer","status":"COMPLETED","sponsor":"Zhejiang Provincial People's Hospital","startDate":"2024-07-03","conditions":"Gastric Cancer, Pancreas Adenocarcinoma","enrollment":10},{"nctId":"NCT03327467","phase":"","title":"Expanded Access Protocol: Umbilical Cord Blood Infusions for Children With Brain Injuries","status":"AVAILABLE","sponsor":"Joanne Kurtzberg, MD","startDate":"","conditions":"Cerebral Palsy, Hydrocephalus, Apraxia of Speech","enrollment":""},{"nctId":"NCT05331872","phase":"PHASE1","title":"Umbilical Cord-derived Mesenchymal Stem Cell Infusion in the Management of Adult Liver Cirrhosis","status":"COMPLETED","sponsor":"Vinmec Research Institute of Stem Cell and Gene Technology","startDate":"2021-01-01","conditions":"Liver Cirrhosis","enrollment":20},{"nctId":"NCT01652092","phase":"NA","title":"Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies","status":"ACTIVE_NOT_RECRUITING","sponsor":"Masonic Cancer Center, University of Minnesota","startDate":"2012-09-04","conditions":"SCID, Omenn's Syndrome, Reticular Dysgenesis","enrollment":57},{"nctId":"NCT04943289","phase":"PHASE1","title":"Intrathecal Administration of DUOC-01 in Adults With Primary Progressive Multiple Sclerosis","status":"COMPLETED","sponsor":"Joanne Kurtzberg, MD","startDate":"2021-01-24","conditions":"Primary Progressive Multiple Sclerosis","enrollment":20},{"nctId":"NCT03828344","phase":"PHASE1","title":"Safety and Tolerability of a Single Intravenous Infusion of BX-U001 in Refractory Rheumatoid Arthritis","status":"NOT_YET_RECRUITING","sponsor":"Baylx Inc.","startDate":"2026-12-01","conditions":"Rheumatoid Arthritis","enrollment":16},{"nctId":"NCT07047456","phase":"PHASE3","title":"Effect of Stem Cell Infusion Time on aGVHD in Patients With Hematological Malignancies Post UCBT","status":"RECRUITING","sponsor":"Anhui Provincial Hospital","startDate":"2025-07-11","conditions":"Acute Graft Versus Host Disease","enrollment":134},{"nctId":"NCT01451502","phase":"NA","title":"Infusion of Cell Populations From Unlicensed Umbilical Cord Blood Units","status":"RECRUITING","sponsor":"Masonic Cancer Center, University of Minnesota","startDate":"2011-10-20","conditions":"Lymphatic Diseases, Hematopoietic Malignancy","enrollment":250},{"nctId":"NCT06807606","phase":"PHASE2","title":"Optimized Cord Blood Transplantation for the Treatment of Patients With High-risk Hematologic Malignancies Who Have Relapsed After First Allogeneic Stem Cell Transplantation","status":"RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2025-03-03","conditions":"Hematologic Malignancies","enrollment":35},{"nctId":"NCT06534255","phase":"PHASE1","title":"A Clinical Trial to Evaluate the Safety, Efficacy, and Pharmacokinetics of MegaLT Injection for Treating Refractory Thrombocytopenia Following Radiotherapy, Chemotherapy, or Transplantation.","status":"ACTIVE_NOT_RECRUITING","sponsor":"Anhui Provincial Hospital","startDate":"2024-12-04","conditions":"Refractory Thrombocytopenia","enrollment":10},{"nctId":"NCT07139509","phase":"PHASE1","title":"Allogeneic UCB-derived, Dual-targeting BCMA/CD19 CAR-T for Relapsed/Refractory Multiple Myeloma","status":"RECRUITING","sponsor":"Xi'an No.3 Hospital","startDate":"2024-10-03","conditions":"Relapsed/Refractory Multiple Myeloma(MM)","enrollment":18},{"nctId":"NCT07227740","phase":"","title":"Testosterone Deficiency and Endothelial Dysfunction After Spinal Cord Injury","status":"RECRUITING","sponsor":"Craig Hospital","startDate":"2025-07-15","conditions":"Spinal Cord Injuries, Endothelial Dysfunction, Testosterone Deficiency","enrollment":48},{"nctId":"NCT07227727","phase":"","title":"Endothelial Dysfunction After SCI","status":"RECRUITING","sponsor":"Craig Hospital","startDate":"2025-07-31","conditions":"Spinal Cord Injuries, Endothelial Dysfunction","enrollment":40},{"nctId":"NCT02727803","phase":"PHASE2","title":"Personalized NK Cell Therapy in CBT","status":"RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2016-05-19","conditions":"Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia, Acute Lymphoblastic Leukemia","enrollment":100},{"nctId":"NCT03913026","phase":"PHASE2","title":"UM171 Expanded Cord Blood In Patients With High-Risk Acute Leukemia/Myelodysplasia","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ciusss de L'Est de l'Île de Montréal","startDate":"2019-04-01","conditions":"High Risk Hematologic Malignancy, Cord Blood Transplant","enrollment":30},{"nctId":"NCT03016806","phase":"","title":"Umbilical Cord Blood Transplantation From Unrelated Donors","status":"RECRUITING","sponsor":"University of Rochester","startDate":"2015-06","conditions":"Acute Leukemia, Immune Deficiency Disorder, Congenital Hematological Disorder","enrollment":30},{"nctId":"NCT07208344","phase":"EARLY_PHASE1","title":"Intravenous Infusion of Umbilical Cord Blood as an Adjunctive Treatment for Alzheimer's Disease","status":"RECRUITING","sponsor":"Anhui Provincial Hospital","startDate":"2025-07-31","conditions":"Alzheimer Disease (AD)","enrollment":30},{"nctId":"NCT07201233","phase":"NA","title":"Clinical Study on the Safety and Efficacy of Umbilical Cord Blood Infusion in Treating Bone Marrow Suppression .","status":"NOT_YET_RECRUITING","sponsor":"Shandong Qilu Stem Cells Engineering Co., Ltd.","startDate":"2025-11-01","conditions":"Bone Marrow Suppression","enrollment":30},{"nctId":"NCT07184385","phase":"PHASE3","title":"A Study of Human Umbilical Cord Blood (REGENECYTE) Infusion in Patients With Post-COVID Condition","status":"NOT_YET_RECRUITING","sponsor":"StemCyte, Inc.","startDate":"2026-03-31","conditions":"Long COVID, Post-COVID-19 Condition, Post-COVID Syndrome","enrollment":60},{"nctId":"NCT07177456","phase":"EARLY_PHASE1","title":"Study on Safety and Efficacy of UCB-MNCs for Radiation-induced Lung Injury","status":"NOT_YET_RECRUITING","sponsor":"Zhejiang Cancer Hospital","startDate":"2025-10-01","conditions":"Radiation-induced Lung Injury","enrollment":10},{"nctId":"NCT07175207","phase":"EARLY_PHASE1","title":"Study on Safety and Efficacy of UCB-MNCs for Chronic Radiation Enteritis","status":"NOT_YET_RECRUITING","sponsor":"Zhejiang Cancer Hospital","startDate":"2025-10-01","conditions":"Chronic Radiation Induced Intestinal Injury, Chronic Radiation Enteritis","enrollment":10},{"nctId":"NCT07110090","phase":"PHASE1","title":"Umbilical Cord Blood Megakaryocyte Injection (XJ-MK-002) for Cancer Therapy-Induced Thrombocytopenia (CTIT)","status":"RECRUITING","sponsor":"Cancer Institute and Hospital, Chinese Academy of Medical Sciences","startDate":"2025-08-28","conditions":"Thrombocytopenia, Cancer","enrollment":16},{"nctId":"NCT05884333","phase":"PHASE2","title":"Cord Blood Transplant in Adults With Blood Cancers","status":"RECRUITING","sponsor":"Memorial Sloan Kettering Cancer Center","startDate":"2023-05-22","conditions":"Acute Myelogenous Leukemia (AML), Acute Lymphoblastic Leukemia (ALL), Chronic Myelogenous Leukemia (CML)","enrollment":54},{"nctId":"NCT01810588","phase":"PHASE2","title":"Targeting the IPA and Matching for the Non-Inherited Maternal Antigen for Haplo-Cord Transplantation","status":"ACTIVE_NOT_RECRUITING","sponsor":"Weill Medical College of Cornell University","startDate":"2012-10-16","conditions":"Hematologic Malignancies","enrollment":270},{"nctId":"NCT07131540","phase":"PHASE1","title":"National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Phase I Study on Safety and Efficacy of Mesenchymal Stem-Cell (MSC) Therapy in Non-Viral Acute-on-Chronic Liver Failure (ACLF)","status":"NOT_YET_RECRUITING","sponsor":"Institute of Liver and Biliary Sciences, India","startDate":"2026-01","conditions":"Acute-On-Chronic Liver Failure","enrollment":10},{"nctId":"NCT03399773","phase":"PHASE2","title":"Infusion of Expanded Cord Blood Cells in Addition to Single Cord Blood Transplant in Treating Patients With Acute Leukemia, Chronic Myeloid Leukemia, or Myelodysplastic Syndromes","status":"ACTIVE_NOT_RECRUITING","sponsor":"Fred Hutchinson Cancer Center","startDate":"2022-05-10","conditions":"Acute Biphenotypic Leukemia, Acute Lymphoblastic Leukemia, Chronic Myelogenous Leukemia, BCR-ABL1 Positive","enrollment":31},{"nctId":"NCT00357565","phase":"PHASE2","title":"Hematopoietic Stem Cell Transplantation in the Treatment of Infant Leukemia","status":"COMPLETED","sponsor":"Masonic Cancer Center, University of Minnesota","startDate":"2005-11","conditions":"Leukemia, Myelodysplastic Syndromes, Childhood Acute Myeloid Leukemia in Remission","enrollment":34},{"nctId":"NCT07131306","phase":"PHASE2","title":"National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem Cell Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patient- Phase-II Trial","status":"NOT_YET_RECRUITING","sponsor":"Institute of Liver and Biliary Sciences, India","startDate":"2027-01","conditions":"Acute-On-Chronic Liver Failure","enrollment":100},{"nctId":"NCT07075315","phase":"PHASE3","title":"National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem-Cell (MSC) Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patients - Phase-III Trial","status":"NOT_YET_RECRUITING","sponsor":"Institute of Liver and Biliary Sciences, India","startDate":"2028-01","conditions":"Acute-On-Chronic Liver Failure","enrollment":100},{"nctId":"NCT03093844","phase":"NA","title":"Haploidentical CD34+ Selected Cells Combined With Single Unit Umbilical Cord Blood Transplant for Treatment of High-risk Hematologic Disorders","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2017-10-12","conditions":"Hematologic Disorders","enrollment":150},{"nctId":"NCT06650553","phase":"NA","title":"Umbilical Cord Blood-Supported Haplo-HSCT for Aplastic Anemia Treatment Study","status":"RECRUITING","sponsor":"Shanxi Bethune Hospital","startDate":"2024-06-01","conditions":"Aplastic Anemias","enrollment":110},{"nctId":"NCT02433509","phase":"PHASE1","title":"Phase I Clinical Safety Study About Human Umbilical Cord Blood Monocyte in the Acute Ischemic Stroke","status":"COMPLETED","sponsor":"China Medical University Hospital","startDate":"2015-05","conditions":"Acute Ischemic Stroke","enrollment":6},{"nctId":"NCT02722668","phase":"PHASE2","title":"UCB Transplant for Hematological Diseases Using a Non Myeloablative Prep","status":"COMPLETED","sponsor":"Masonic Cancer Center, University of Minnesota","startDate":"2017-05-15","conditions":"Acute Leukemia, Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia/Lymphoma","enrollment":15},{"nctId":"NCT04260698","phase":"PHASE3","title":"Expanded Access of Omidubicel, for Allogeneic Transplantation in Patients With Hematological Malignancies","status":"COMPLETED","sponsor":"Gamida Cell ltd","startDate":"2020-07-08","conditions":"Hematological Malignancies","enrollment":36},{"nctId":"NCT07021534","phase":"PHASE1","title":"Hepatic Artery Transfusion of NKG2D CAR-NK Cells Followed by Intravenous Infusion of NKG2D CAR-T Cells to Treat Patients With Advanced Solid Tumors With Liver Metastases Who Have Failed Standard Treatments: a Phase I Exploratory Clinical Trial","status":"RECRUITING","sponsor":"Zhejiang University","startDate":"2025-06-10","conditions":"Patients With Advanced Solid Tumors With Liver Metastases Who Have Failed Standard Treatments","enrollment":12},{"nctId":"NCT06995274","phase":"NA","title":"Umbilical Cord Blood Therapy in a Child With Eosinophilic Duodenitis and Autism Spectrum Disorder: a Case Study","status":"NOT_YET_RECRUITING","sponsor":"Bundang CHA Hospital","startDate":"2025-06-01","conditions":"Autism Spectrum Disorder, Eosinophilic Gastrointestinal Disorders","enrollment":1},{"nctId":"NCT03434730","phase":"PHASE2","title":"Tocilizumab for the Prevention of Graft Versus Host Disease After Cord Blood Transplantation","status":"COMPLETED","sponsor":"Memorial Sloan Kettering Cancer Center","startDate":"2018-02-07","conditions":"Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Acute Leukemia","enrollment":46},{"nctId":"NCT04325594","phase":"PHASE1, PHASE2","title":"The Application of the Umbilical Cord Mesenchymal Stem Cells in the Complex Treatment of Non-ischemic Heart Failure","status":"COMPLETED","sponsor":"The Research-Clinical Center for Cardiac Surgery and Transplantology LLP","startDate":"2020-03-01","conditions":"Chronic Heart Failure, Non-ischemic Cardiomyopathy, Non-ischemic Dilated Cardiomyopathy","enrollment":30},{"nctId":"NCT03773393","phase":"PHASE1","title":"A Clinical Trial of CK0801 (a New Drug) in Patients With Bone Marrow Failure Syndrome (BMF)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Cellenkos, Inc.","startDate":"2019-05-30","conditions":"Bone Marrow Disease","enrollment":18},{"nctId":"NCT05423691","phase":"PHASE1","title":"Leading in MPNs Beyond Ruxolitinib in Combo With T-Regs","status":"RECRUITING","sponsor":"Cellenkos, Inc.","startDate":"2022-12-27","conditions":"Myelofibrosis","enrollment":24},{"nctId":"NCT05695521","phase":"PHASE1","title":"Regulatory T Cells for Amyotrophic Lateral Sclerosis","status":"ACTIVE_NOT_RECRUITING","sponsor":"Cellenkos, Inc.","startDate":"2023-04-03","conditions":"Amyotrophic Lateral Sclerosis","enrollment":66},{"nctId":"NCT05682560","phase":"PHASE2","title":"Human Umbilical Cord Blood (RegeneCyte) Infusion in Patients with Post-COVID Syndrome","status":"COMPLETED","sponsor":"StemCyte, Inc.","startDate":"2023-05-04","conditions":"Long COVID, Post-COVID Syndrome, Post COVID-19 Condition","enrollment":30},{"nctId":"NCT06889155","phase":"NA","title":"Comparative Study Between Oxytocin Infusion Before and After Placental Delivery on Blood Loss During and After Cesarean Delivery .","status":"COMPLETED","sponsor":"Cairo University","startDate":"2023-08-30","conditions":"Intraoperative Blood Loss","enrollment":64},{"nctId":"NCT06792682","phase":"PHASE1","title":"The Safety and Efficacy of Umbilical Cord Blood Mononuclear Cells in Patients With Secondary Poor Graft Function After Hematopoietic Stem Cell Transplantation","status":"RECRUITING","sponsor":"Institute of Hematology & Blood Diseases Hospital, China","startDate":"2025-02-14","conditions":"Poor Graft Function","enrollment":15},{"nctId":"NCT00619879","phase":"","title":"Myeloablative Hematopoietic Progenitor Cell Transplantation (HPCT) for Pediatric Malignancies","status":"COMPLETED","sponsor":"Ann & Robert H Lurie Children's Hospital of Chicago","startDate":"2007-03-26","conditions":"Leukemia, Myelogenous, Chronic, Leukemia, Lymphoblastic, Acute, Leukemia, Myelogenous, Acute","enrollment":81},{"nctId":"NCT02179359","phase":"NA","title":"Hematopoietic Stem Cell Transplant for High Risk Hemoglobinopathies","status":"TERMINATED","sponsor":"Masonic Cancer Center, University of Minnesota","startDate":"2014-09-02","conditions":"Sickle Cell Disease, Transfusion Dependent Alpha- or Beta- Thalassemia, Diamond Blackfan Anemia","enrollment":38},{"nctId":"NCT06040476","phase":"PHASE2","title":"Human Umbilical Cord Blood Infusion in Patients with Acute Ischemic Stroke (AIS)","status":"NOT_YET_RECRUITING","sponsor":"StemCyte, Inc.","startDate":"2025-09","conditions":"Acute Ischemic Stroke","enrollment":39},{"nctId":"NCT06848582","phase":"NA","title":"Umbilical Cord Blood NK Cell Therapy for High-Risk Pediatric Soft Tissue Sarcoma: Efficacy and Safety Study","status":"RECRUITING","sponsor":"Sun Yat-sen University","startDate":"2024-11-01","conditions":"Soft Tissue Sarcoma (STS)","enrollment":40},{"nctId":"NCT06377982","phase":"PHASE1","title":"Human Umbilical Cord Blood Infusion in Patients with Cerebral Palsy","status":"NOT_YET_RECRUITING","sponsor":"StemCyte Taiwan Co., Ltd.","startDate":"2025-09","conditions":"Cerebral Palsy","enrollment":12},{"nctId":"NCT06631391","phase":"PHASE1","title":"Phase I Study of Umbilical Cord Blood Natural Killer (NK) Cell Therapy for Children With High-risk, R/R Neuroblastoma.","status":"RECRUITING","sponsor":"Sun Yat-sen University","startDate":"2024-11-01","conditions":"Neuroblastoma","enrollment":30},{"nctId":"NCT06464861","phase":"PHASE1","title":"Sequential Treatment of CD19 CARNK and 7x19 CAR-T in R/R B Cell Lymphoma","status":"RECRUITING","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2024-06-20","conditions":"Primary Mediastinal B-cell Lymphoma (PMBCL), Mantle Cell Lymphoma (MCL), Diffuse Large B Cell Lymphoma( DLBCL)","enrollment":52},{"nctId":"NCT03931408","phase":"PHASE2","title":"Gentamicin Bladder Instillation in Individuals With Spinal Cord Injury Having Chronic Urinary Tract Infections","status":"COMPLETED","sponsor":"University of Louisville","startDate":"2019-02-19","conditions":"Neurogenic Bladder, Spinal Cord Injuries","enrollment":6},{"nctId":"NCT04083170","phase":"PHASE2","title":"Cord Blood Transplant With Dilanubicel for the Treatment of HIV Positive Hematologic Cancers","status":"TERMINATED","sponsor":"Fred Hutchinson Cancer Center","startDate":"2022-10-06","conditions":"Acute Erythroid Leukemia, Acute Lymphoblastic Leukemia, Acute Megakaryoblastic Leukemia","enrollment":1},{"nctId":"NCT06558253","phase":"PHASE1","title":"The Safety and Efficacy of Coenzyme I for Injection in Promoting Hematopoietic Recovery of Patients After sUCBT","status":"RECRUITING","sponsor":"Anhui Provincial Hospital","startDate":"2024-11-29","conditions":"Hematopoietic Recovery","enrollment":12},{"nctId":"NCT06729320","phase":"NA","title":"A Randomized Controlled, Open, Single-center Clinical Study Evaluating the Efficacy and Safety of Umbilical Cord Blood Mononuclear Cells in Patients with Refractory Immune Effector Cell-related Hemocytopenia","status":"NOT_YET_RECRUITING","sponsor":"Beijing GoBroad Hospital","startDate":"2024-12-01","conditions":"Refractory Immune Effector Cell-related Hemocytopenia","enrollment":40},{"nctId":"NCT02039557","phase":"","title":"Long Term Follow Up Protocol for NiCord®/CordIn™ (Omidubicel) Patients","status":"COMPLETED","sponsor":"Gamida Cell ltd","startDate":"2014-05-01","conditions":"Patients Transplanted With NiCord/CordIn (Omidubicel)","enrollment":33},{"nctId":"NCT06443151","phase":"","title":"Role of Endothelial Function in SCI CVD Risk","status":"RECRUITING","sponsor":"Craig Hospital","startDate":"2024-09-01","conditions":"Spinal Cord Injuries, Cardiovascular Diseases, Endothelial Dysfunction","enrollment":60},{"nctId":"NCT05290545","phase":"PHASE3","title":"Haplo-PBSC+Cord vs Haplo-PBSC+BM for Hematological Malignancies Undergoing Allo-HSCT","status":"COMPLETED","sponsor":"Nanfang Hospital, Southern Medical University","startDate":"2022-02-15","conditions":"Hematological Malignancies, Hematopoietic Stem Cell Transplantation","enrollment":314},{"nctId":"NCT01050855","phase":"PHASE2","title":"Reduced Intensity Conditioning (RIC) Regimen for Patients With Non-malignant Disorders","status":"ACTIVE_NOT_RECRUITING","sponsor":"Children's Hospital of Philadelphia","startDate":"2008-01","conditions":"Non Malignant Diseases, Immunodeficiencies, Hemoglobinopathies","enrollment":75},{"nctId":"NCT05027048","phase":"PHASE3","title":"Calcium Chloride for Prevention of Blood Loss During Intrapartum Cesarean Delivery","status":"COMPLETED","sponsor":"Stanford University","startDate":"2022-04-04","conditions":"Uterine Atony, Uterine Atony With Hemorrhage, Postpartum Hemorrhage","enrollment":120},{"nctId":"NCT05345418","phase":"PHASE1, PHASE2","title":"Umbilical Cord-Derived Mesenchymal Stem Cell (VCELL 1) for Male Patients With Sexual Deficiency","status":"RECRUITING","sponsor":"Vinmec Research Institute of Stem Cell and Gene Technology","startDate":"2022-04-01","conditions":"Sexual Dysfunction Male","enrollment":158},{"nctId":"NCT06427642","phase":"NA","title":"Efficacy Evaluation of UCB-MNCs in the Treatment of Refractory Neonatal Diseases","status":"RECRUITING","sponsor":"Shandong Qilu Stem Cells Engineering Co., Ltd.","startDate":"2022-04-01","conditions":"Hypoxic-Ischemic Encephalopathy, Bronchopulmonary Dysplasia, Short Bowel Syndrome","enrollment":120},{"nctId":"NCT02612155","phase":"PHASE2","title":"A Multi-site Study of Autologous Cord Blood Cells for Hypoxic Ischemic Encephalopathy","status":"COMPLETED","sponsor":"Michael Cotten","startDate":"2017-03-30","conditions":"Moderate or Severe Hypoxic-ischemic Encephalopathy in Newborns","enrollment":35},{"nctId":"NCT01445041","phase":"PHASE1","title":"Safety and Feasibility Study of Umbilical Cord Blood Cells for Infants With Hypoplastic Left Heart Syndrome","status":"TERMINATED","sponsor":"Michael Cotten","startDate":"2011-09-01","conditions":"Hypoplastic Left Heart Syndrome","enrollment":7},{"nctId":"NCT00593242","phase":"PHASE1","title":"Cord Blood for Neonatal Hypoxic-ischemic Encephalopathy","status":"COMPLETED","sponsor":"Michael Cotten","startDate":"2008-01","conditions":"Neonatal Hypoxic Ischemic Encephalopathy","enrollment":52},{"nctId":"NCT02065596","phase":"PHASE1","title":"Hematopoietic Stem Cell Transplant for Sickle Cell Disease","status":"COMPLETED","sponsor":"Case Comprehensive Cancer Center","startDate":"2015-10-19","conditions":"Sickle Cell Disease, Sickle Cell Anemia, SCD","enrollment":4},{"nctId":"NCT03902067","phase":"PHASE1","title":"UC-MSC Transplantation for Left Ventricular Dysfunction After AMI","status":"UNKNOWN","sponsor":"Shanghai Life Science & Technology","startDate":"2024-12-01","conditions":"Left Ventricular Dysfunction, Acute Myocardial Infarction","enrollment":40},{"nctId":"NCT01656603","phase":"PHASE2","title":"Safety Study of Unlicensed IND Cord Blood Units Manufactured by the National Cord Blood Program for Unrelated Transplantation","status":"RECRUITING","sponsor":"New York Blood Center","startDate":"2012-02","conditions":"Infusion Reactions","enrollment":9999},{"nctId":"NCT03635450","phase":"PHASE1","title":"Study of hCT-MSC in Newborn Infants With Moderate or Severe HIE","status":"COMPLETED","sponsor":"Joanne Kurtzberg, MD","startDate":"2018-12-27","conditions":"Moderate to Severe Hypoxic-ischemic Encephalopathy","enrollment":6},{"nctId":"NCT01033552","phase":"PHASE1, PHASE2","title":"Biochemical Correction of Severe EB by Allo HSCT and \"Off-the-shelf\" MSCs","status":"COMPLETED","sponsor":"Masonic Cancer Center, University of Minnesota","startDate":"2010-01","conditions":"Epidermolysis Bullosa","enrollment":32},{"nctId":"NCT03056339","phase":"PHASE1, PHASE2","title":"Umbilical & Cord Blood (CB) Derived CAR-Engineered NK Cells for B Lymphoid Malignancies","status":"COMPLETED","sponsor":"M.D. Anderson Cancer Center","startDate":"2017-06-21","conditions":"B-Lymphoid Malignancies, Acute Lymphocytic Leukemia, Chronic Lymphocytic Leukemia","enrollment":49},{"nctId":"NCT02508324","phase":"PHASE2","title":"IPA Targeted Adoptive Immunotherapy vs Adult Haplo-identical Cell Infusion During Induction of High Risk Leukemia","status":"TERMINATED","sponsor":"Weill Medical College of Cornell University","startDate":"2015-09-10","conditions":"Acute Myeloid Leukemia, Myelodysplastic Syndrome","enrollment":43}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":49,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Stem cell infusion"],"phase":"phase_2","status":"active","brandName":"Cord Blood Infusion","genericName":"Cord Blood Infusion","companyName":"Joanne Kurtzberg, MD","companyId":"joanne-kurtzberg-md","modality":"Biologic","firstApprovalDate":"","aiSummary":"Cord blood infusion involves the transfer of hematopoietic stem cells from the umbilical cord to a recipient to stimulate the production of new blood cells. Used for Treatment of severe combined immunodeficiency (SCID), Treatment of leukemia and lymphoma, Treatment of other blood-related disorders.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":3,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}