{"id":"conventional-migraine-drug-treatment","safety":{"commonSideEffects":[{"rate":"1-5","effect":"Chest pain or pressure"},{"rate":"5-10","effect":"Dizziness"},{"rate":"5-15","effect":"Nausea"},{"rate":"5-10","effect":"Flushing"},{"rate":"5-10","effect":"Tingling or paresthesia"},{"rate":"3-8","effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Conventional migraine treatments typically include triptans (5-HT1B/1D receptor agonists causing cranial vasoconstriction), ergot alkaloids, and NSAIDs that reduce inflammation and pain signaling. These agents target the trigeminal system and cerebral blood vessels to abort migraine attacks or prevent their progression. The specific mechanism depends on the drug class used, ranging from direct vasoconstrictive effects to modulation of neuropeptide release.","oneSentence":"Conventional migraine drugs work through multiple mechanisms including vasoconstriction, serotonin receptor modulation, and pain pathway inhibition to relieve acute migraine symptoms.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:43:53.710Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute migraine with or without aura"},{"name":"Migraine prophylaxis (for certain agents)"}]},"trialDetails":[{"nctId":"NCT06764914","phase":"","title":"Integrative and Complementary Therapy for Episodic Migraine and Tension-type Headache","status":"NOT_YET_RECRUITING","sponsor":"Kliniken Essen-Mitte","startDate":"2025-01-01","conditions":"Migraine, Headache, Tension-Type","enrollment":130},{"nctId":"NCT05967442","phase":"PHASE3","title":"Magnesium Versus Prochlorperazine Versus Metoclopramide for Migraines","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2019-08-23","conditions":"Migraine, Headache","enrollment":157},{"nctId":"NCT05199064","phase":"","title":"Efficacy of Greater Occipital Nerve Radiofrequency for Refractory Migraine Treatment","status":"COMPLETED","sponsor":"Tepecik Training and Research Hospital","startDate":"2020-09-15","conditions":"Migraine, Headache Disorders, Primary","enrollment":25},{"nctId":"NCT02777359","phase":"PHASE2","title":"Precutaneous High Risk Patent Foramen Ovale to Treat Migraine Headaches","status":"UNKNOWN","sponsor":"First Affiliated Hospital Xi'an Jiaotong University","startDate":"2017-01","conditions":"Patent Foramen Ovale","enrollment":100},{"nctId":"NCT01476930","phase":"PHASE4","title":"Cupping and Serkangabin Versus Conventional Migraine Treatment","status":"COMPLETED","sponsor":"Birjand University of Medical Sciences","startDate":"2008-06","conditions":"Migraine Headache","enrollment":391},{"nctId":"NCT01096420","phase":"NA","title":"Acupuncture in Chronic Migraine: A Randomized Controlled Trial","status":"COMPLETED","sponsor":"Kuang Tien General Hospital","startDate":"2008-08","conditions":"Patients With Chronic Migraine","enrollment":68}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"conventional migraine drug treatment","genericName":"conventional migraine drug treatment","companyName":"Birjand University of Medical Sciences","companyId":"birjand-university-of-medical-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Conventional migraine drugs work through multiple mechanisms including vasoconstriction, serotonin receptor modulation, and pain pathway inhibition to relieve acute migraine symptoms. Used for Acute migraine with or without aura, Migraine prophylaxis (for certain agents).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}