{"id":"conventional-antihypertensive-drugs","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness or lightheadedness"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Cough (ACE inhibitors)"},{"rate":null,"effect":"Edema (calcium channel blockers)"},{"rate":null,"effect":"Hypotension"}]},"_chembl":{"chemblId":"CHEMBL1863515","moleculeType":"Enzyme"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a broad category encompassing multiple drug classes (ACE inhibitors, beta-blockers, calcium channel blockers, diuretics, alpha-blockers) that work through distinct mechanisms to reduce blood pressure. They may act by inhibiting the renin-angiotensin system, blocking sympathetic nervous system activity, dilating blood vessels, or reducing blood volume. The KVT-Study Group likely evaluated one or more of these established antihypertensive classes in a clinical trial.","oneSentence":"Conventional antihypertensive drugs lower blood pressure through various mechanisms including vasodilation, reduced cardiac output, or decreased peripheral vascular resistance.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:31:08.621Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"},{"name":"Blood pressure management"}]},"trialDetails":[{"nctId":"NCT07350564","phase":"NA","title":"Intensive Versus Conventional Blood Pressure Control Following Stroke Thrombectomy","status":"RECRUITING","sponsor":"Hao Yonggang","startDate":"2025-11-01","conditions":"Stroke","enrollment":910},{"nctId":"NCT07272486","phase":"NA","title":"The Use of Virtual Reality and Music Therapy for Hypertensive Urgency","status":"COMPLETED","sponsor":"Ankara City Hospital 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Aldosteronism","status":"COMPLETED","sponsor":"University Hospital, Toulouse","startDate":"2009-06","conditions":"Adenoma","enrollment":96},{"nctId":"NCT03001739","phase":"PHASE1","title":"Intensive Blood PRessure Control in Patients With Acute Type B AortIc Dissection","status":"UNKNOWN","sponsor":"Sir Run Run Shaw Hospital","startDate":"2016-12","conditions":"Blood High Pressure, Aortic Dissection Type B","enrollment":360},{"nctId":"NCT02999048","phase":"PHASE4","title":"Clinical Study on the Treatment of Hypertensive Intracerebral Hemorrhage With Panax Notoginseng Saponin","status":"COMPLETED","sponsor":"The First People's Hospital of Jingzhou","startDate":"2014-05","conditions":"Hematoma Absorption and Neurological Function Recovery","enrollment":90},{"nctId":"NCT01691118","phase":"PHASE4","title":"A Trial of Fimasartan for Early Diastolic Heart Failure","status":"COMPLETED","sponsor":"Asan Medical 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Used for Hypertension, Blood pressure management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}