{"id":"conventional-amphotericin-b","safety":{"commonSideEffects":[{"rate":"80","effect":"Nephrotoxicity (acute kidney injury)"},{"rate":"80","effect":"Infusion-related reactions (fever, chills, rigors)"},{"rate":"25","effect":"Hypokalemia"},{"rate":"15","effect":"Hypomagnesemia"},{"rate":"20","effect":"Anemia"},{"rate":"null","effect":"Phlebitis at infusion site"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Amphotericin B is a polyene antibiotic that selectively targets ergosterol, a sterol unique to fungal cell membranes. By binding to ergosterol, it forms ion channels in the membrane, causing leakage of intracellular contents and ultimately fungal cell lysis. The conventional formulation has higher nephrotoxicity compared to lipid-based formulations due to its interaction with mammalian cholesterol.","oneSentence":"Amphotericin B binds to ergosterol in fungal cell membranes, creating pores that disrupt membrane integrity and lead to cell death.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:07:38.134Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Systemic fungal infections (invasive aspergillosis, candidiasis, cryptococcosis)"},{"name":"Empiric antifungal therapy in febrile neutropenic patients"},{"name":"Leishmaniasis"}]},"trialDetails":[{"nctId":"NCT05814432","phase":"PHASE3","title":"Efficacy and Safety of High-dose Liposomal Amphotericin B for Disseminated Histoplasmosis in AIDS","status":"RECRUITING","sponsor":"Federal University of Health Science of Porto Alegre","startDate":"2025-01-16","conditions":"Disseminated Histoplasma Capsulatum Infection, AIDS and Infections, Immunosuppression","enrollment":279},{"nctId":"NCT04502381","phase":"PHASE2","title":"Combined Inhalational With Intravenous Amphotericin B Versus Intravenous Amphotericin B Alone for Pulmonary Mucormycosis","status":"COMPLETED","sponsor":"Post Graduate Institute of Medical Education and Research, Chandigarh","startDate":"2020-07-01","conditions":"Pulmonary Mucormycosis","enrollment":30},{"nctId":"NCT02366884","phase":"PHASE2","title":"Clinical Evaluation of a New Form of Cancer Therapy (Atavistic Chemotherapy) Based on the Principles of Atavistic Metamorphosis (2011)","status":"UNKNOWN","sponsor":"Dr. Frank Arguello Cancer Clinic","startDate":"2011-07-26","conditions":"Neoplasms","enrollment":250},{"nctId":"NCT00815516","phase":"PHASE3","title":"Study to Compare the Efficacy and Safety of Micafungin Versus Conventional Amphotericin B for the Treatment of Neonatal Candidiasis","status":"TERMINATED","sponsor":"Astellas Pharma Global Development, Inc.","startDate":"2013-02","conditions":"Candidiasis","enrollment":30},{"nctId":"NCT00163111","phase":"PHASE3","title":"A Clinical Study Intended To Compare Treatment With Voriconazole To Treatment With Amphotericin Followed By Fluconazole In Patients With Candidemia, A Serious Fungus Infection Of The Blood.","status":"COMPLETED","sponsor":"Pfizer","startDate":"1998-09","conditions":"Candidiasis","enrollment":412}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":369,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Conventional amphotericin B","genericName":"Conventional amphotericin B","companyName":"Pfizer","companyId":"pfizer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Amphotericin B binds to ergosterol in fungal cell membranes, creating pores that disrupt membrane integrity and lead to cell death. Used for Systemic fungal infections (invasive aspergillosis, candidiasis, cryptococcosis), Empiric antifungal therapy in febrile neutropenic patients, Leishmaniasis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}