{"id":"control-group-autologous-icbg","safety":{"commonSideEffects":[{"rate":null,"effect":"Pain at donor site (iliac crest)"},{"rate":null,"effect":"Infection"},{"rate":null,"effect":"Hematoma"},{"rate":null,"effect":"Nerve injury"},{"rate":null,"effect":"Graft site complications"}]},"_chembl":{"chemblId":"CHEMBL2108795","moleculeType":"Vaccine component"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"ICBG is a surgical procedure in which bone tissue is harvested from the patient's own iliac crest and transplanted to another site requiring bone repair or reconstruction. The graft provides osteoconductive scaffolding, osteoinductive growth factors (including BMPs and other cytokines), and osteogenic cells that facilitate new bone formation and integration with host bone.","oneSentence":"Autologous iliac crest bone graft (ICBG) provides structural support and biological factors to promote bone healing and regeneration at the graft site.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:31:05.324Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bone defects and non-unions requiring surgical reconstruction"},{"name":"Spinal fusion procedures"},{"name":"Maxillofacial and craniofacial bone reconstruction"}]},"trialDetails":[{"nctId":"NCT04234971","phase":"PHASE4","title":"Cost Effectiveness in Alveolar Bone Grafting in Patients With Cleft Lip and Palate","status":"RECRUITING","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2021-06-14","conditions":"Cleft Lip and Palate","enrollment":40},{"nctId":"NCT04294004","phase":"PHASE2","title":"KUR-113 Bone Graft Versus Local Autograft for the Treatment of Single-level Transforaminal Lumbar Interbody Fusion","status":"UNKNOWN","sponsor":"Kuros Biosurgery AG","startDate":"2020-08-27","conditions":"Degenerative Disc Disease, Spinal Fusion","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Control group(autologous ICBG)","genericName":"Control group(autologous ICBG)","companyName":"The University of Texas Health Science Center, Houston","companyId":"the-university-of-texas-health-science-center-houston","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Autologous iliac crest bone graft (ICBG) provides structural support and biological factors to promote bone healing and regeneration at the graft site. Used for Bone defects and non-unions requiring surgical reconstruction, Spinal fusion procedures, Maxillofacial and craniofacial bone reconstruction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}