{"id":"continuous-interscalene-brachial-plexus-block","phase":"phase_1","safety":{"boxedWarnings":[],"safetySignals":[],"drugInteractions":[],"commonSideEffects":["Horner's syndrome","Phrenic nerve palsy","Hoarseness","Numbness and weakness in affected arm"],"contraindications":["Patient refusal","Infection at insertion site","Coagulopathy","Contralateral phrenic nerve dysfunction"],"specialPopulations":{},"discontinuationRates":[],"seriousAdverseEvents":[]},"status":"active","trials":["NCT05775861"],"aliases":[],"patents":[],"pricing":[],"modality":"Small molecule","timeline":[],"aiSummary":"","brandName":"continuous interscalene brachial plexus block","companyId":"ciusss-de-l-est-de-l-le-de-montr-al","mechanism":{"target":"Voltage-gated sodium channels","novelty":"","modality":"Small molecule","drugClass":"","explanation":"Local anesthetics block voltage-gated sodium channels in nerve cell membranes, preventing depolarization and transmission of pain signals from the shoulder and upper extremity. The continuous catheter technique maintains prolonged nerve blockade for extended postoperative analgesia.","oneSentence":"Delivers local anesthetic agents continuously to the brachial plexus nerve bundle, blocking sodium channels and preventing pain signal transmission.","technicalDetail":""},"commercial":null,"_claudeStub":{"ts":1779123318,"model":"claude-sonnet-4-5-20250929"},"companyName":"Ciusss de L'Est de l'Île de Montréal","competitors":[{"name":"single-shot interscalene block","brand":null,"company":null,"rationale":"Alternative regional anesthesia technique for same surgical indications"},{"name":"continuous supraclavicular brachial plexus block","brand":null,"company":null,"rationale":"Alternative brachial plexus approach for upper extremity analgesia"},{"name":"patient-controlled analgesia with opioids","brand":null,"company":null,"rationale":"Systemic alternative for postoperative pain management"}],"description":"Continuous interscalene brachial plexus block is a regional anesthesia technique involving catheter placement near the brachial plexus at the neck level to provide ongoing pain relief for shoulder and upper arm procedures. It delivers local anesthetic continuously to block nerve signals.","genericName":"continuous interscalene brachial plexus block","indications":{"approved":[{"status":"investigational","condition":"Postoperative pain management following shoulder surgery","patientPopulation":"Adult surgical patients"}],"offLabel":[],"pipeline":[]},"labelChanges":[],"trialDetails":[],"manufacturing":[],"administration":{"icon":"","route":"","frequency":"","formulation":""},"formularyStatus":[],"apiManufacturers":[],"developmentCodes":[],"ownershipHistory":[],"biosimilarFilings":[],"firstApprovalDate":"","companionDiagnostics":[],"firstApprovalCountry":null,"rwe":[],"genericFilers":[],"relatedDrugs":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}