{"id":"conjugated-equine-estrogen-topical-cream","safety":{"commonSideEffects":[{"rate":null,"effect":"Vaginal irritation or burning"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Breast tenderness"},{"rate":null,"effect":"Vaginal bleeding or spotting"}]},"_chembl":{"chemblId":"CHEMBL2108947","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The cream contains a mixture of estrogen compounds derived from pregnant mare urine, which are absorbed through the vaginal epithelium. These estrogens bind to estrogen receptors in vaginal and vulvar tissues, promoting epithelial proliferation, increasing blood flow, and restoring moisture and elasticity to atrophic tissues. This localized hormone replacement therapy alleviates symptoms of genitourinary syndrome of menopause without requiring systemic absorption.","oneSentence":"Conjugated equine estrogen topical cream delivers estrogen directly to vaginal and vulvar tissues to relieve menopausal symptoms such as vaginal atrophy and dryness.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:30:54.456Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Vaginal atrophy and dryness associated with menopause"},{"name":"Genitourinary syndrome of menopause (GSM)"}]},"trialDetails":[{"nctId":"NCT05118685","phase":"PHASE1","title":"Estrogen and Platelet Rich Plasma in Treatment of Atrophic Vaginitis","status":"UNKNOWN","sponsor":"Fayoum University","startDate":"2021-11-13","conditions":"Atrophic Vaginitis, Postmenopausal Atrophic Vaginitis","enrollment":100},{"nctId":"NCT02869165","phase":"PHASE4","title":"Vaginal and Urinary Microbiome Trial","status":"COMPLETED","sponsor":"University of Louisville","startDate":"2017-01","conditions":"Atrophic Vaginitis, Menopause, Recurrent Urinary Tract Infections","enrollment":110},{"nctId":"NCT00465894","phase":"NA","title":"Detrol Long Acting (LA) vs Estrace Vaginal Cream for the Treatment of Overactive Bladder Symptoms","status":"COMPLETED","sponsor":"University of Alabama at Birmingham","startDate":"2007-04","conditions":"Overactive Bladder","enrollment":58}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Premarin vaginal cream","Vaginal estrogen cream","CEE topical cream"],"phase":"marketed","status":"active","brandName":"Conjugated equine estrogen topical cream","genericName":"Conjugated equine estrogen topical cream","companyName":"University of Louisville","companyId":"university-of-louisville","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Conjugated equine estrogen topical cream delivers estrogen directly to vaginal and vulvar tissues to relieve menopausal symptoms such as vaginal atrophy and dryness. Used for Vaginal atrophy and dryness associated with menopause, Genitourinary syndrome of menopause (GSM).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}