{"id":"concentrated-bone-marrow-aspirate-injection","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or swelling"},{"rate":null,"effect":"Temporary increase in inflammation"},{"rate":null,"effect":"Infection at injection or aspiration site"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This product is an autologous cell therapy that concentrates mononuclear cells, mesenchymal stem cells, and hematopoietic stem cells from a patient's own bone marrow. When injected into damaged tissue, these cells and their secreted factors (cytokines, growth factors) promote angiogenesis, reduce inflammation, and stimulate endogenous repair mechanisms. The mechanism leverages the regenerative and immunomodulatory properties of bone marrow-derived stem cells.","oneSentence":"Concentrated bone marrow aspirate delivers autologous stem cells and growth factors to promote tissue regeneration and reduce inflammation at the injection site.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:30:58.935Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Osteoarthritis (knee, hip, shoulder)"},{"name":"Cartilage defects"},{"name":"Tendon and ligament injuries"},{"name":"Bone defects"}]},"trialDetails":[{"nctId":"NCT04990128","phase":"PHASE3","title":"Bone Marrow Aspirate Concentrate Versus Triamcinolone Injection For Hip Osteoarthritis","status":"NOT_YET_RECRUITING","sponsor":"The Cleveland Clinic","startDate":"2026-03-01","conditions":"Hip Osteoarthritis","enrollment":100},{"nctId":"NCT07434115","phase":"EARLY_PHASE1","title":"Orthobiological Therapies in Musculoskeletal Disorders","status":"NOT_YET_RECRUITING","sponsor":"PROREGEN","startDate":"2026-01-30","conditions":"Musculoskeletal Diseases or Conditions","enrollment":300},{"nctId":"NCT06040957","phase":"NA","title":"Bone Marrow Versus Adipose Tissue as a Cell Source for Infiltrative Treatment of Knee Osteoarthritis","status":"RECRUITING","sponsor":"Istituto Ortopedico Rizzoli","startDate":"2024-01-08","conditions":"Knee Osteoarthritis","enrollment":204},{"nctId":"NCT07386548","phase":"NA","title":"Biologic Injection For Adults With Lumbar Disc Herniation","status":"NOT_YET_RECRUITING","sponsor":"Weill Medical College of Cornell University","startDate":"2026-02-01","conditions":"Degenerative Disc Disease, DDD, Degenerative Disc Disease Lumbar","enrollment":90},{"nctId":"NCT06311513","phase":"PHASE4","title":"Concentrated Bone Marrow Aspirate in Revision ACL Reconstruction","status":"RECRUITING","sponsor":"Hospital for Special Surgery, New York","startDate":"2024-01-22","conditions":"Anterior Cruciate Ligament Injuries, Post-Traumatic Osteoarthritis of Knee, Bone Marrow Aspirate Concentrate","enrollment":40},{"nctId":"NCT04735185","phase":"NA","title":"Stem Cells vs. Steroids for Discogenic Back Pain","status":"WITHDRAWN","sponsor":"Johns Hopkins University","startDate":"2025-09-30","conditions":"Chronic Low Back Pain, Degenerative Disc Disease","enrollment":""},{"nctId":"NCT04883892","phase":"NA","title":"Evaluation of the Single Injection of BMAC vs HA in the Treatment of the Ankle Osteoarthritis","status":"TERMINATED","sponsor":"Istituto Ortopedico Rizzoli","startDate":"2021-12-15","conditions":"Ankle Osteoarthritis","enrollment":18},{"nctId":"NCT05985785","phase":"NA","title":"Bone Marrow Aspirate Concentrate (BMAC) vs Corticosteroid Injection","status":"RECRUITING","sponsor":"Rush University Medical Center","startDate":"2022-07-19","conditions":"Osteoarthritis of the Knee","enrollment":100},{"nctId":"NCT06353503","phase":"NA","title":"Bone Marrow Aspirate Concentrate for Anterior Cruciate Ligament Tear Treatment.","status":"RECRUITING","sponsor":"abdulmajeed hammadi","startDate":"2024-04-02","conditions":"Anterior Cruciate Ligament Tear","enrollment":20},{"nctId":"NCT03289416","phase":"PHASE4","title":"Bone Marrow Aspirate Compared to Platelet Rich Plasma for Treating Knee Osteoarthritis","status":"COMPLETED","sponsor":"Andrews Research & Education Foundation","startDate":"2013-12-05","conditions":"Knee Osteoarthritis","enrollment":90},{"nctId":"NCT03517761","phase":"NA","title":"Use of Bone Marrow Concentrate for Treatment of Alar, Accessory, and Transverse Ligament Injuries","status":"RECRUITING","sponsor":"Regenexx, LLC","startDate":"2018-03-23","conditions":"Craniocervical Injuries","enrollment":80},{"nctId":"NCT02582489","phase":"NA","title":"Autologous Bone Marrow Aspirate Concentrate in Patients Undergoing Meniscectomy","status":"RECRUITING","sponsor":"Rush University Medical Center","startDate":"2017-12-22","conditions":"Osteoarthritis Post-meniscectomy","enrollment":100},{"nctId":"NCT05507099","phase":"PHASE2","title":"Stem Cell Study in Osteoarthritis of the Knee and Hip Joints","status":"RECRUITING","sponsor":"Grigory Karmy","startDate":"2022-08-23","conditions":"Osteoarthritis","enrollment":400},{"nctId":"NCT06164899","phase":"","title":"Long-term Evaluation of Outcomes of Patients Undergoing Autologous Bone Marrow Concentrate Infiltration vs. Hyaluronic Acid","status":"COMPLETED","sponsor":"Istituto Ortopedico Rizzoli","startDate":"2024-02-09","conditions":"Knee Osteoarthritis","enrollment":60},{"nctId":"NCT06750757","phase":"PHASE4","title":"Intraoperative Bone Marrow Aspirate Concentrate Injections: Evaluating Outcomes in a Randomized Controlled Trial","status":"NOT_YET_RECRUITING","sponsor":"American Hip Institute","startDate":"2025-02","conditions":"Labral Tear, Femoroacetabular Impingement","enrollment":80},{"nctId":"NCT02863926","phase":"PHASE1","title":"Use of Autologous Concentrated Bone Marrow Aspirate in Preventing Wound Complications in Below Knee Amputation (BKA)","status":"COMPLETED","sponsor":"Michael Murphy","startDate":"2017-01-06","conditions":"Peripheral Artery Disease, Vascular Disease, Critical Limb Ischemia","enrollment":6},{"nctId":"NCT06700772","phase":"PHASE1","title":"Histomorphometric and Radiographic Evaluation of Bone Following Maxillary Sinus Augmentation","status":"RECRUITING","sponsor":"Cairo University","startDate":"2024-12-01","conditions":"Sinus Floor Elevation","enrollment":26},{"nctId":"NCT06216028","phase":"PHASE3","title":"Bone Marrow Aspirate Concentrate (BMAC) Treatment for Knee Osteoarthritis","status":"NOT_YET_RECRUITING","sponsor":"CELL Technologies Inc.","startDate":"2024-09","conditions":"Knee Osteoarthritis, Musculoskeletal Diseases","enrollment":374},{"nctId":"NCT04815902","phase":"PHASE1, PHASE2","title":"Use of Senolytic and Anti-Fibrotic Agents to Improve the Beneficial Effect of Bone Marrow Stem Cells for Osteoarthritis","status":"ACTIVE_NOT_RECRUITING","sponsor":"Steadman Philippon Research Institute","startDate":"2021-05-18","conditions":"Osteoarthritis, Knee","enrollment":100},{"nctId":"NCT05193877","phase":"NA","title":"Autologous Bone Marrow Aspirate Concentrate Injection for the Treatment of Early Osteoarthritis:Baghdad 2022","status":"COMPLETED","sponsor":"Global Stem Cell Center, Baghdad","startDate":"2022-02-08","conditions":"Treatment Complication","enrollment":60},{"nctId":"NCT03818737","phase":"PHASE3","title":"Multicenter Trial of Stem Cell Therapy for Osteoarthritis (MILES)","status":"COMPLETED","sponsor":"Emory University","startDate":"2019-03-28","conditions":"Osteoarthritis","enrollment":475},{"nctId":"NCT02285725","phase":"NA","title":"Microdrilling Surgery for Full Thickness Chondral Lesions of the Knee Augmented With Concentrated Bone Marrow Aspirate, Platelet Rich Plasma and Hyaluronic Acid","status":"COMPLETED","sponsor":"Joseph E. Broyles","startDate":"2011-03","conditions":"Unilateral Primary Osteoarthritis of Knee, Osteoarthritis Knee, Degeneration; Articular Cartilage, Knee","enrollment":21},{"nctId":"NCT03648463","phase":"NA","title":"Use of MRI Labeling Technique to Track Mesenchymal Stem Cell Survival in Orthopaedic Conditions","status":"WITHDRAWN","sponsor":"Stanford University","startDate":"2019-10-01","conditions":"Cartilage Degeneration, Rotator Cuff Tear, Osteoarthritis, Knee","enrollment":""},{"nctId":"NCT03110666","phase":"PHASE4","title":"Treatment for Knee Osteoarthritis With Injections of BMC at the Bone-cartilage Interface. Pilot Study","status":"COMPLETED","sponsor":"Istituto Ortopedico Rizzoli","startDate":"2016-11-14","conditions":"Knee Osteoarthritis","enrollment":17},{"nctId":"NCT03912454","phase":"NA","title":"A Prospective Study of Clinical Outcomes Following a Single Intradiscal Injection of Bone Marrow Aspirate Concentrate (BMAC) for Single Level Discogenic Low Back Pain","status":"UNKNOWN","sponsor":"Bone and Joint Clinic of Baton Rouge","startDate":"2019-04-08","conditions":"Degenerative Disc Disease, Spine Degeneration","enrollment":20},{"nctId":"NCT03410355","phase":"NA","title":"Bone Marrow Aspirate Concentrate Use in Hip Osteoarthritis","status":"TERMINATED","sponsor":"Nova Scotia Health Authority","startDate":"2018-02-01","conditions":"Osteoarthritis, Hip","enrollment":6},{"nctId":"NCT04716803","phase":"NA","title":"Bone Marrow Aspirate Concentrate (BMAC)Treatment for Knee Osteoarthritis","status":"RECRUITING","sponsor":"University of California, San Diego","startDate":"2020-07-08","conditions":"Osteo Arthritis Knee","enrollment":10},{"nctId":"NCT04102761","phase":"NA","title":"The Use of PRP and BMC in Patients With Internal Disc Disruption Multicenter Prospective Randomized Controlled Trial in Patients With Internal Disc Disruption","status":"COMPLETED","sponsor":"Annu Navani","startDate":"2018-03-27","conditions":"Internal Disc Disruption","enrollment":45},{"nctId":"NCT03579407","phase":"NA","title":"Open Ended Trocar vs. Fenestrated Blunt Trocar in Bone Marrow Aspirate for Osteoarthritis","status":"TERMINATED","sponsor":"Advanced Orthopaedic Specialists","startDate":"2019-01-10","conditions":"Osteoarthritis, Knee","enrollment":15},{"nctId":"NCT01049919","phase":"NA","title":"Safety and Efficacy Study of Autologous Concentrated Bone Marrow Aspirate (cBMA) for Critical Limb Ischemia (CLI)","status":"TERMINATED","sponsor":"Zimmer Biomet","startDate":"2010-06","conditions":"Critical Limb Ischemia, Peripheral Arterial Disease, Peripheral Vascular Disease","enrollment":153},{"nctId":"NCT02981394","phase":"","title":"Clinical Outcomes of Autologous Bone Marrow Aspirate Concentrate Injections for Musculoskeletal Conditions","status":"WITHDRAWN","sponsor":"Rush University Medical Center","startDate":"2016-11","conditions":"Musculoskeletal Pain, Osteoarthritis, Tendinopathy","enrollment":""},{"nctId":"NCT03688308","phase":"NA","title":"Bone Marrow Derived Stem Cells for the Treatment of Rotator Cuff Tears","status":"WITHDRAWN","sponsor":"Stanford University","startDate":"2020-01-01","conditions":"Rotator Cuff Tear, Rotator Cuff Injury","enrollment":""},{"nctId":"NCT03100695","phase":"NA","title":"Tibial Fracture - Platelet-rich Plasma and Bone Marrow Concentrate","status":"UNKNOWN","sponsor":"University of Leeds","startDate":"2018-10-04","conditions":"Unilateral Tibial Diaphyseal Fracture","enrollment":45},{"nctId":"NCT03908827","phase":"PHASE2, PHASE3","title":"BMAC in Severe Hip or Knee Osteoarthritis Awaiting Arthroplasty","status":"WITHDRAWN","sponsor":"CAPRI Clinic","startDate":"2019-12","conditions":"Osteoarthritis, Knee, Osteoarthritis, Hip","enrollment":""},{"nctId":"NCT02474121","phase":"","title":"Safety and Efficacy of Autologous Concentrated Bone Marrow Aspirate for Critical Limb Ischemia - Continued Access","status":"NO_LONGER_AVAILABLE","sponsor":"Zimmer Biomet","startDate":"","conditions":"Peripheral Arterial Disease, Peripheral Vascular Diseases, Critical Limb Ischemia","enrollment":""},{"nctId":"NCT04310852","phase":"","title":"Knee Osteoarthritis Treatment With Percutaneous Injections of Autologous Bone Marrow Concentrate","status":"UNKNOWN","sponsor":"Istituto Clinico Humanitas","startDate":"2018-06-06","conditions":"Knee Osteoarthritis, Cartilage Degeneration","enrollment":25},{"nctId":"NCT03271229","phase":"PHASE2","title":"Conventional Platelet-Rich Plasma Versus Concentrated Bone Marrow Stem Cell Injections for Osteoarthritis of the Knee","status":"WITHDRAWN","sponsor":"Mayo Clinic","startDate":"2019-09","conditions":"Osteo Arthritis Knee","enrollment":""},{"nctId":"NCT02958267","phase":"PHASE2","title":"Investigation of Mesenchymal Stem Cell Therapy for the Treatment of Osteoarthritis of the Knee","status":"COMPLETED","sponsor":"OhioHealth","startDate":"2016-12","conditions":"Knee Osteoarthritis","enrollment":32},{"nctId":"NCT02011295","phase":"NA","title":"Bone Marrow Aspirate Concentrate (BMAC) Supplementation for Osteochondral Lesions","status":"COMPLETED","sponsor":"Duke University","startDate":"2014-01-29","conditions":"Osteochondral Lesions of Talus","enrollment":17},{"nctId":"NCT03557606","phase":"","title":"Case Series on Using Bone Marrow Concentrate for Alar Ligament Injuries","status":"WITHDRAWN","sponsor":"Regenexx, LLC","startDate":"2018-08-20","conditions":"Craniocervical Injuries","enrollment":""},{"nctId":"NCT03825133","phase":"PHASE4","title":"The Comparison of Knee Osteoarthritis Treatment With Bone Marrow Aspirate Concentrate , Leukocyte Rich Platelet Rich Plasma and Hyaluronic Acid","status":"COMPLETED","sponsor":"Clinical Center of Vojvodina","startDate":"2016-04-01","conditions":"Knee Osteoarthritis","enrollment":180},{"nctId":"NCT01931007","phase":"PHASE1","title":"Use of Autologous Bone Marrow Aspirate Concentrate in Painful Knee Osteoarthritis","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2013-08","conditions":"Bilateral Primary Osteoarthritis of Knee","enrollment":25},{"nctId":"NCT01245335","phase":"PHASE3","title":"Bone Marrow Aspirate Concentrate (BMAC) for Treatment of Critical Limb Ischemia (CLI)","status":"COMPLETED","sponsor":"Harvest Technologies","startDate":"2011-05","conditions":"Critical Limb Ischemia","enrollment":97},{"nctId":"NCT01285297","phase":"NA","title":"Safety Study of Transmyocardial Revascularization (TMR) With Bone Marrow Aspirate (BMAC) for Angina Reduction","status":"TERMINATED","sponsor":"Cardiogenesis Corporation, a wholly-owned subsidiary of CryoLife, Inc.","startDate":"2010-10","conditions":"Angina","enrollment":7},{"nctId":"NCT00498069","phase":"NA","title":"Study of Autologous Bone Marrow Concentrate for the Treatment of Critical Limb Ischemia (CLI)","status":"COMPLETED","sponsor":"Harvest Technologies","startDate":"2007-11","conditions":"Ischemia","enrollment":48},{"nctId":"NCT01061580","phase":"PHASE1, PHASE2","title":"BMAC Enhanced Coronary Artery Bypass Grafting (CABG)","status":"TERMINATED","sponsor":"Harvest Technologies","startDate":"2010-05","conditions":"Congestive Heart Failure","enrollment":20},{"nctId":"NCT00595257","phase":"PHASE1, PHASE2","title":"Feasability Study of Autologous Bone Marrow Aspirate Concentrate for Treatment of CLI","status":"COMPLETED","sponsor":"Harvest Technologies","startDate":"2007-12","conditions":"Arterial Occlusive Diseases","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":10,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["cBMA","BMAC","Bone Marrow Aspirate Concentrate"],"phase":"marketed","status":"active","brandName":"Concentrated Bone Marrow Aspirate Injection","genericName":"Concentrated Bone Marrow Aspirate Injection","companyName":"Hospital for Special Surgery, New York","companyId":"hospital-for-special-surgery-new-york","modality":"Biologic","firstApprovalDate":"","aiSummary":"Concentrated Bone Marrow Aspirate Injection is a treatment that has been studied for various conditions, including sinus floor elevation, osteoarthritis of the knee, and congestive heart failure, typically involving the injection of bone marrow aspirate concentrate mixed with bovine bone or autogenous bone. The exact mechanism of action of Concentrated Bone Marrow Aspirate Injection is currently unknown.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}