{"id":"compound-kushen-injection-cki","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Allergic reactions"}]},"_chembl":{"chemblId":"CHEMBL2108760","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"CKI is derived from Kushen (Sophora flavescens) and contains active alkaloid compounds that promote cancer cell apoptosis, inhibit tumor angiogenesis, and enhance immune function. The injection formulation is used primarily in combination with chemotherapy to improve treatment efficacy and reduce adverse effects in cancer patients.","oneSentence":"Compound Kushen Injection is a traditional Chinese medicine-derived herbal extract that exerts anti-tumor and immunomodulatory effects through multiple pathways including apoptosis induction and immune system activation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:40:05.034Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Adjunctive treatment in non-small cell lung cancer"},{"name":"Adjunctive treatment in gastric cancer"},{"name":"Adjunctive treatment in colorectal cancer"},{"name":"Supportive care in cancer chemotherapy"}]},"trialDetails":[{"nctId":"NCT05894694","phase":"PHASE4","title":"Survival Benefit of Compound Kushen Injection in the Treatment of Advanced Colorectal Cancer","status":"RECRUITING","sponsor":"Guang'anmen Hospital of China Academy of Chinese Medical Sciences","startDate":"2023-09-27","conditions":"Advanced Colorectal Carcinoma","enrollment":320},{"nctId":"NCT05259540","phase":"PHASE2","title":"Effect of Compound Kushen Injection Combined With Pabolizumab in the Treatment of Cervical Adenocarcinoma","status":"UNKNOWN","sponsor":"Women's Hospital School Of Medicine Zhejiang University","startDate":"2023-01-01","conditions":"Cervical Cancer","enrollment":42},{"nctId":"NCT04204382","phase":"PHASE4","title":"Effects of CKI for Oral Mucositis Caused by Radiotherapy for Head and Neck Cancer","status":"UNKNOWN","sponsor":"Shanxi Zhendong Pharmacy Co., Ltd","startDate":"2019-12-12","conditions":"Radiation-induced Oral Mucositis","enrollment":144},{"nctId":"NCT02239237","phase":"","title":"Post-marketing Safety Surveillance of Compound Kuh-seng Injection: a Registry Study","status":"COMPLETED","sponsor":"Zhong Wang","startDate":"2014-09","conditions":"Safety Surveillance, Adverse Drug Events, Adverse Drug Reactions","enrollment":30283},{"nctId":"NCT02346318","phase":"PHASE4","title":"The Randomized Controlled Clinical Trial of Kushen Injection","status":"UNKNOWN","sponsor":"Beijing Zheng Ju Medical Technology Co., Ltd.","startDate":"2014-11","conditions":"Lung Cancer","enrollment":240}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Yanshu injection"],"phase":"marketed","status":"active","brandName":"Compound Kushen Injection（CKI）","genericName":"Compound Kushen Injection（CKI）","companyName":"Shanxi Zhendong Pharmacy Co., Ltd","companyId":"shanxi-zhendong-pharmacy-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Compound Kushen Injection is a traditional Chinese medicine-derived herbal extract that exerts anti-tumor and immunomodulatory effects through multiple pathways including apoptosis induction and immune system activation. Used for Adjunctive treatment in non-small cell lung cancer, Adjunctive treatment in gastric cancer, Adjunctive treatment in colorectal cancer.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}