{"id":"comparison-2-liberal-fluids","safety":{"commonSideEffects":[{"rate":null,"effect":"Fluid overload / pulmonary edema"},{"rate":null,"effect":"Peripheral edema"},{"rate":null,"effect":"Increased complications (context-dependent)"}]},"_chembl":{"chemblId":"CHEMBL3694257","moleculeType":"Small molecule","molecularWeight":"608.76"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Liberal fluid strategies involve administering larger volumes of intravenous fluids perioperatively or in critical care settings to expand circulating blood volume and improve tissue perfusion. This approach aims to optimize cardiac preload and oxygen delivery to vital organs, though the optimal fluid volume remains clinically debated.","oneSentence":"Liberal fluid administration increases intravascular volume to maintain adequate perfusion and organ function.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:40:05.843Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Perioperative fluid management"},{"name":"Critical illness and sepsis management"}]},"trialDetails":[{"nctId":"NCT03068741","phase":"PHASE4","title":"Paramedic Initiated Treatment of Sepsis Targeting Out-of-hospital Patients (PITSTOP)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Dr. Damon Scales","startDate":"2020-03-23","conditions":"Severe Sepsis or Septic Shock","enrollment":2040},{"nctId":"NCT04780490","phase":"NA","title":"Comparison of Liberal and Restrictive Fluid Management on the Endothelial Glycocalyx in Radical Cystectomy","status":"COMPLETED","sponsor":"Istanbul University","startDate":"2018-03-01","conditions":"Fluid Retention Tissue","enrollment":37},{"nctId":"NCT04265014","phase":"NA","title":"Comparison of Goal-directed and Liberal Fluid Management","status":"WITHDRAWN","sponsor":"Bakirkoy Dr. Sadi Konuk Research and Training Hospital","startDate":"2020-01-01","conditions":"Goal-Directed Fluid Therapy, Hemodynamic Monitoring, Fluid Management","enrollment":""},{"nctId":"NCT03475784","phase":"PHASE3","title":"Two Fluid Strategies for Prevention of Post-dural Puncture Headache","status":"COMPLETED","sponsor":"Cairo University","startDate":"2018-03-30","conditions":"Post-Dural Puncture Headache","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["intravenous saline (0.9%) for injection"],"phase":"marketed","status":"active","brandName":"Comparison 2: Liberal fluids","genericName":"Comparison 2: Liberal fluids","companyName":"Dr. Damon Scales","companyId":"dr-damon-scales","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Liberal fluid administration increases intravascular volume to maintain adequate perfusion and organ function. Used for Perioperative fluid management, Critical illness and sepsis management.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}