{"id":"comparison-2-conservative-fluids","safety":{"commonSideEffects":[{"rate":null,"effect":"Acute kidney injury"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Tissue hypoperfusion"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Conservative fluid protocols limit the volume and rate of IV fluid delivery during perioperative care or critical illness, aiming to reduce pulmonary edema, tissue edema, and organ dysfunction. This approach contrasts with liberal fluid strategies and is based on evidence that excessive fluid administration can worsen outcomes in certain patient populations, particularly in surgery and sepsis management.","oneSentence":"Conservative fluid management is a clinical strategy that restricts intravenous fluid administration to minimize fluid overload and associated complications.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:30:51.931Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Perioperative fluid management in major surgery"},{"name":"Sepsis and critical illness fluid resuscitation"}]},"trialDetails":[{"nctId":"NCT03068741","phase":"PHASE4","title":"Paramedic Initiated Treatment of Sepsis Targeting Out-of-hospital Patients (PITSTOP)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Dr. Damon Scales","startDate":"2020-03-23","conditions":"Severe Sepsis or Septic Shock","enrollment":2040},{"nctId":"NCT03923816","phase":"PHASE1, PHASE2","title":"Implication of Fluid Strategies Upon Hepatic Outcome in Hepatobiliary Surgery","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2019-10-01","conditions":"Hepatic Complication","enrollment":100},{"nctId":"NCT00749060","phase":"NA","title":"Comparison of Balloon Kyphoplasty, Vertebroplasty and Conservative Management in Acute Osteoporotic Vertebral Fractures","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2007-12","conditions":"Osteoporotic Vertebral Fracture, Between T5 and L5, of Less Than 6 Weeks Duration","enrollment":48}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["intravenous saline (0.9%) for injection"],"phase":"marketed","status":"active","brandName":"Comparison 2: Conservative fluids","genericName":"Comparison 2: Conservative fluids","companyName":"Dr. Damon Scales","companyId":"dr-damon-scales","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Conservative fluid management is a clinical strategy that restricts intravenous fluid administration to minimize fluid overload and associated complications. Used for Perioperative fluid management in major surgery, Sepsis and critical illness fluid resuscitation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}