{"id":"comparison-1-prehospital-ceftriaxone","safety":{"commonSideEffects":[{"rate":"1-3%","effect":"Hypersensitivity reactions (rash, urticaria)"},{"rate":"1-2%","effect":"Diarrhea"},{"rate":"1-2%","effect":"Phlebitis at injection site"},{"rate":"1-3%","effect":"Elevated liver enzymes"},{"rate":"1%","effect":"Eosinophilia"}]},"_chembl":{"chemblId":"CHEMBL6067656","moleculeType":"Small molecule","molecularWeight":"1323.22"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ceftriaxone works by disrupting the cross-linking of peptidoglycan in bacterial cell walls, leading to cell wall instability and bacterial death. It has broad-spectrum activity against gram-positive and gram-negative bacteria, making it suitable for empiric treatment of serious infections in prehospital settings. The drug is bactericidal and achieves good tissue penetration, including into the central nervous system.","oneSentence":"Ceftriaxone is a third-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:30:44.887Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prehospital empiric treatment of serious bacterial infections"},{"name":"Meningitis"},{"name":"Sepsis"},{"name":"Community-acquired pneumonia"}]},"trialDetails":[{"nctId":"NCT03068741","phase":"PHASE4","title":"Paramedic Initiated Treatment of Sepsis Targeting Out-of-hospital Patients (PITSTOP)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Dr. Damon Scales","startDate":"2020-03-23","conditions":"Severe Sepsis or Septic Shock","enrollment":2040}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Ceftriaxone"],"phase":"marketed","status":"active","brandName":"Comparison 1: Prehospital Ceftriaxone","genericName":"Comparison 1: Prehospital Ceftriaxone","companyName":"Dr. Damon Scales","companyId":"dr-damon-scales","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ceftriaxone is a third-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins. Used for Prehospital empiric treatment of serious bacterial infections, Meningitis, Sepsis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}