{"id":"comparator-sumatriptan","safety":{"commonSideEffects":[{"rate":"1-5","effect":"Chest pain or pressure"},{"rate":"5-10","effect":"Dizziness"},{"rate":"5-10","effect":"Somnolence"},{"rate":"5-15","effect":"Tingling or paresthesia"},{"rate":"5-10","effect":"Flushing"},{"rate":"5-10","effect":"Asthenia or fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Sumatriptan binds to 5-HT1B receptors on cranial blood vessels causing vasoconstriction, and to 5-HT1D receptors on trigeminal nerve terminals to reduce the release of vasoactive neuropeptides. This dual action addresses both the vascular and neurogenic components of migraine pathophysiology, providing rapid symptom relief.","oneSentence":"Sumatriptan is a selective serotonin 5-HT1B/1D receptor agonist that constricts cranial blood vessels and inhibits neuropeptide release to relieve migraine headaches.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:45:15.019Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute migraine with or without aura"},{"name":"Cluster headache"}]},"trialDetails":[{"nctId":"NCT00894556","phase":"PHASE3","title":"A Study to Evaluate the Efficacy and Tolerability of Rizatriptan for Treatment of Acute Migraine (0462-087)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2009-06-10","conditions":"Acute Migraine","enrollment":109},{"nctId":"NCT00898677","phase":"PHASE3","title":"Rizatriptan 5 mg and 10 mg, Sumatriptan 100 mg, and Placebo Comparison Study (0462-030)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"1995-09","conditions":"Migraine Headache","enrollment":1268},{"nctId":"NCT00897104","phase":"PHASE3","title":"MK0462 5 mg, Sumatriptan 50 mg, and Placebo Comparison Study (0462-029)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"1995-08","conditions":"Migraine Headache","enrollment":933},{"nctId":"NCT00892203","phase":"PHASE2","title":"Efficacy and Safety of BGG492 in the Treatment of Migraine","status":"COMPLETED","sponsor":"Novartis","startDate":"2009-04","conditions":"Migraine","enrollment":75},{"nctId":"NCT02571049","phase":"PHASE2","title":"Pilot Study of Two Different Strengths of DFN-11 Injection for Rapidly Escalating Migraine","status":"COMPLETED","sponsor":"Dr. Reddy's Laboratories Limited","startDate":"2015-09","conditions":"Rapidly Escalating Migraine","enrollment":24},{"nctId":"NCT00240617","phase":"PHASE3","title":"Study Of Treximet, Formerly Known as Trexima, In The Acute Treatment Of Multiple Migraine Attacks","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2005-10","conditions":"Migraine Disorders","enrollment":623},{"nctId":"NCT01016678","phase":"PHASE2, PHASE3","title":"Treximet Early Intervention Adolescent Migraine","status":"COMPLETED","sponsor":"Premiere Research Institute","startDate":"2010-03","conditions":"Migraine","enrollment":104}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1036,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["sumatriptan"],"phase":"phase_3","status":"active","brandName":"Comparator: sumatriptan","genericName":"Comparator: sumatriptan","companyName":"Organon and Co","companyId":"organon-and-co","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sumatriptan is a selective serotonin 5-HT1B/1D receptor agonist that constricts cranial blood vessels and inhibits neuropeptide release to relieve migraine headaches. Used for Acute migraine with or without aura, Cluster headache.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}