{"id":"comparator-rizatriptan-benzoate","safety":{"commonSideEffects":[{"rate":"9","effect":"Dizziness"},{"rate":"8","effect":"Somnolence"},{"rate":"5","effect":"Asthenia/fatigue"},{"rate":"7","effect":"Nausea"},{"rate":"2","effect":"Chest pain/pressure"},{"rate":"1","effect":"Palpitations"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Rizatriptan works by binding to 5-HT1B and 5-HT1D receptors on cranial blood vessels and trigeminal nerve terminals. This causes vasoconstriction of dilated intracranial vessels and reduces the release of vasoactive neuropeptides involved in migraine pathophysiology, thereby terminating acute migraine attacks.","oneSentence":"Rizatriptan benzoate is a selective serotonin 5-HT1B/1D receptor agonist that constricts cranial blood vessels and inhibits neuropeptide release to relieve migraine headaches.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:07:15.531Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute migraine with or without aura"}]},"trialDetails":[{"nctId":"NCT00111722","phase":"PHASE3","title":"Study to Test a Marketed Drug in the Treatment of Menstrual Migraine (0462-072)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2005-05-27","conditions":"Migraine","enrollment":393},{"nctId":"NCT00095004","phase":"PHASE3","title":"Study to Test an Approved Product in the Early Treatment of Migraine (0462-066)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2004-10-21","conditions":"Migraine","enrollment":167},{"nctId":"NCT00111709","phase":"PHASE3","title":"Study to Test a Marketed Drug in the Treatment of Menstrual Migraine (0462-071)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2005-05-27","conditions":"Migraine","enrollment":393},{"nctId":"NCT00092963","phase":"PHASE3","title":"Study to Test an Approved Product in the Early Treatment of Migraine (0462-065)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2004-08-17","conditions":"Migraine","enrollment":529},{"nctId":"NCT00812006","phase":"PHASE3","title":"A Study of Rizatriptan for the Treatment of Acute Migraine in Patients on Topiramate for Migraine Prophylaxis","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2009-03-24","conditions":"Migraine","enrollment":108},{"nctId":"NCT00516737","phase":"PHASE3","title":"Study to Test Rizatriptan in the Early Treatment of Acute Migraine (0462-081)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2007-10-03","conditions":"Migraine","enrollment":207},{"nctId":"NCT00899379","phase":"PHASE3","title":"Treatment of Multiple Attacks of Acute Migraine (0462-025)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"1995-04","conditions":"Migraine Headache","enrollment":473},{"nctId":"NCT00898677","phase":"PHASE3","title":"Rizatriptan 5 mg and 10 mg, Sumatriptan 100 mg, and Placebo Comparison Study (0462-030)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"1995-09","conditions":"Migraine Headache","enrollment":1268},{"nctId":"NCT00897949","phase":"PHASE3","title":"MK0462 in Treatment of Migraine With Recurrence (MK0462-022)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"1995-03","conditions":"Migraine Headache","enrollment":1473},{"nctId":"NCT00897104","phase":"PHASE3","title":"MK0462 5 mg, Sumatriptan 50 mg, and Placebo Comparison Study (0462-029)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"1995-08","conditions":"Migraine Headache","enrollment":933}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":9,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["MK0462"],"phase":"phase_3","status":"active","brandName":"Comparator: rizatriptan benzoate","genericName":"Comparator: rizatriptan benzoate","companyName":"Organon and Co","companyId":"organon-and-co","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Rizatriptan benzoate is a selective serotonin 5-HT1B/1D receptor agonist that constricts cranial blood vessels and inhibits neuropeptide release to relieve migraine headaches. Used for Acute migraine with or without aura.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}