{"id":"comparator-proquad-v221","safety":{"commonSideEffects":[{"rate":"15-20","effect":"Injection site reactions (erythema, swelling, tenderness)"},{"rate":"10-15","effect":"Fever"},{"rate":"3-5","effect":"Rash"},{"rate":"1-3","effect":"Varicella-like rash"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"ProQuad contains live weakened strains of measles, mumps, rubella, and varicella-zoster viruses that replicate in vaccinated individuals, triggering both humoral and cell-mediated immune responses. This results in the production of antibodies and T-cell immunity against all four viruses, providing protection against these infectious diseases. The vaccine is administered as a single injection combining what were previously given as separate MMR and varicella vaccines.","oneSentence":"ProQuad is a live attenuated combination vaccine that stimulates immune response against measles, mumps, rubella, and varicella viruses.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:07:18.697Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of measles, mumps, rubella, and varicella in children and adults"}]},"trialDetails":[{"nctId":"NCT00109343","phase":"PHASE3","title":"V221 Concomitant Use Study With Pneumococcal Conjugate Vaccine (V221-019)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2006-03","conditions":"Measles, Mumps, Rubella","enrollment":1027},{"nctId":"NCT00975507","phase":"PHASE3","title":"ProQuad™ Versus M-M-R II™ and VARIVAX™ in Healthy Children (V221-009)(COMPLETED)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"1998-03","conditions":"Measles, Mumps, Rubella","enrollment":480}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["ProQuad™","V221"],"phase":"phase_3","status":"active","brandName":"Comparator: ProQuad™ (V221)","genericName":"Comparator: ProQuad™ (V221)","companyName":"Merck Sharp & Dohme LLC","companyId":"merck","modality":"Biologic","firstApprovalDate":"","aiSummary":"ProQuad is a live attenuated combination vaccine that stimulates immune response against measles, mumps, rubella, and varicella viruses. Used for Prevention of measles, mumps, rubella, and varicella in children and adults.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}