{"id":"comparator-pranlukast","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Abdominal pain"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Pranlukast selectively antagonizes cysteinyl leukotriene receptors (CysLT1), preventing the binding of leukotrienes (LTC4, LTD4, LTE4) that are released during allergic and inflammatory responses. By blocking these receptors, it reduces airway inflammation, mucus secretion, and bronchoconstriction, thereby improving airflow and reducing asthma symptoms.","oneSentence":"Pranlukast is a cysteinyl leukotriene receptor antagonist that blocks the inflammatory effects of leukotrienes in the airways.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:07:10.074Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Asthma (allergic and exercise-induced)"},{"name":"Allergic rhinitis"}]},"trialDetails":[{"nctId":"NCT00127647","phase":"PHASE3","title":"An Approved Drug to Study a New Indication for Allergic Rhinitis (0476-327)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2004-11","conditions":"Rhinitis, Allergic, Seasonal","enrollment":1375}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":116,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Comparator: pranlukast","genericName":"Comparator: pranlukast","companyName":"Organon and Co","companyId":"organon-and-co","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Pranlukast is a cysteinyl leukotriene receptor antagonist that blocks the inflammatory effects of leukotrienes in the airways. Used for Asthma (allergic and exercise-induced), Allergic rhinitis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}