{"id":"comparator-montelukast","safety":{"commonSideEffects":[{"rate":"18","effect":"Headache"},{"rate":"4","effect":"Influenza-like illness"},{"rate":"3","effect":"Abdominal pain"},{"rate":"3","effect":"Cough"},{"rate":null,"effect":"Neuropsychiatric effects (mood changes, suicidality)"}]},"_chembl":{"chemblId":"CHEMBL1200681","moleculeType":"Small molecule","molecularWeight":"608.18"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Leukotrienes are inflammatory mediators released by mast cells and eosinophils that promote airway constriction, mucus secretion, and eosinophil recruitment. By antagonizing the CysLT1 receptor, montelukast reduces these inflammatory responses in asthma and allergic rhinitis. This mechanism is distinct from beta-agonists and corticosteroids, making it useful as add-on therapy or for specific phenotypes like aspirin-exacerbated respiratory disease.","oneSentence":"Montelukast blocks cysteinyl leukotriene receptors (CysLT1) on airway and immune cells, preventing leukotriene-mediated inflammation and bronchoconstriction.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:30:37.351Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Asthma (maintenance and acute prevention)"},{"name":"Allergic rhinitis"},{"name":"Aspirin-exacerbated respiratory disease (AERD)"},{"name":"Exercise-induced bronchoconstriction"}]},"trialDetails":[{"nctId":"NCT06429475","phase":"PHASE3","title":"Anti-Inflammatory Reliever South Africa","status":"RECRUITING","sponsor":"University of KwaZulu","startDate":"2024-06-06","conditions":"Asthma","enrollment":1038},{"nctId":"NCT04885530","phase":"PHASE3","title":"ACTIV-6: COVID-19 Study of Repurposed 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Asthma","status":"COMPLETED","sponsor":"Sanofi","startDate":"2002-02","conditions":"Asthma","enrollment":1200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1138,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Singulair","SINGULAIR®, PROAIR® HFA"],"phase":"marketed","status":"active","brandName":"Comparator: Montelukast","genericName":"Comparator: Montelukast","companyName":"Organon and Co","companyId":"organon-and-co","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Montelukast blocks cysteinyl leukotriene receptors (CysLT1) on airway and immune cells, preventing leukotriene-mediated inflammation and bronchoconstriction. Used for Asthma (maintenance and acute prevention), Allergic rhinitis, Aspirin-exacerbated respiratory disease (AERD).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}