{"id":"comparator-fluvastatin","safety":{"commonSideEffects":[{"rate":"2-5%","effect":"Myalgia (muscle pain)"},{"rate":"5-9%","effect":"Headache"},{"rate":"3-5%","effect":"Dyspepsia"},{"rate":"1-3%","effect":"Elevated liver enzymes (ALT/AST)"},{"rate":"<0.1%","effect":"Rhabdomyolysis"}]},"_chembl":{"chemblId":"CHEMBL2220442","moleculeType":"Small molecule","molecularWeight":"411.47"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fluvastatin is a competitive inhibitor of HMG-CoA reductase, which catalyzes the conversion of HMG-CoA to mevalonate in the cholesterol biosynthetic pathway. By blocking this enzyme, fluvastatin decreases hepatic cholesterol production, leading to upregulation of LDL receptors on hepatocytes and increased clearance of LDL cholesterol from the bloodstream. This results in reduced plasma LDL cholesterol concentrations and improved lipid profiles.","oneSentence":"Fluvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:07:01.007Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypercholesterolemia and dyslipidemia for reduction of cardiovascular risk"},{"name":"Primary and secondary prevention of coronary heart disease"}]},"trialDetails":[{"nctId":"NCT00132717","phase":"PHASE3","title":"A 12 Week Study of MK0653A in Patients Who Have Been Hospitalized for a Possible Heart Problem (0653A-808)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2005-01-01","conditions":"Hypercholesterolemia","enrollment":450}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":786,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Comparator: fluvastatin","genericName":"Comparator: fluvastatin","companyName":"Organon and Co","companyId":"organon-and-co","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Fluvastatin is a small molecule used to treat hypercholesterolemia. It is a comparator in clinical trials, often compared to other statins such as atorvastatin.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}