{"id":"comparator-comvax","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Injection site reactions (pain, redness, swelling)"},{"rate":"1-3","effect":"Fever"},{"rate":"1-3","effect":"Irritability"},{"rate":"1-3","effect":"Drowsiness"}]},"_chembl":{"chemblId":"CHEMBL3983509","moleculeType":"Small molecule","molecularWeight":"434.92"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Comvax contains recombinant hepatitis B surface antigen and Hib polysaccharide conjugate, which work together to induce humoral immune responses. The vaccine primes B cells and T cells to recognize and respond to these pathogens, providing long-term protection against hepatitis B infection and invasive Hib disease.","oneSentence":"Comvax is a combination vaccine that provides immunization against hepatitis B virus and Haemophilus influenzae type b (Hib) by stimulating the immune system to produce protective antibodies against both pathogens.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:06:59.418Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Immunization against hepatitis B virus infection"},{"name":"Immunization against Haemophilus influenzae type b (Hib) infection"}]},"trialDetails":[{"nctId":"NCT00984295","phase":"PHASE3","title":"Frozen ProQuad Administered Concomitantly Versus Nonconcomitantly With Other Pediatric Vaccines","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2000-06","conditions":"Measles, Mumps, Rubella","enrollment":1913},{"nctId":"NCT00441012","phase":"PHASE3","title":"Study of Modified Process Hib/Hep B Vaccine in Infants (V121-019)(COMPLETED)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2006-12","conditions":"Haemophilus Influenzae Type B, Hepatitis B","enrollment":546}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Comparator: Comvax","genericName":"Comparator: Comvax","companyName":"Merck Sharp & Dohme LLC","companyId":"merck-sharp-dohme-llc","modality":"Biologic","firstApprovalDate":"","aiSummary":"Comvax is a combination vaccine that provides immunization against hepatitis B virus and Haemophilus influenzae type b (Hib) by stimulating the immune system to produce protective antibodies against both pathogens. Used for Immunization against hepatitis B virus infection, Immunization against Haemophilus influenzae type b (Hib) infection.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}