{"id":"comparator-cetirizine","safety":{"commonSideEffects":[{"rate":"2-3%","effect":"Headache"},{"rate":"1-2%","effect":"Somnolence"},{"rate":"1-2%","effect":"Fatigue"},{"rate":"1-2%","effect":"Dry mouth"},{"rate":"1-2%","effect":"Pharyngitis"}]},"_chembl":{"chemblId":"CHEMBL1607273","moleculeType":"Small molecule","molecularWeight":"461.82"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Cetirizine competitively binds to peripheral H1 histamine receptors on mast cells, basophils, and other immune cells, preventing histamine from triggering allergic cascade reactions. Due to its hydrophilic nature and low lipophilicity, it has minimal blood-brain barrier penetration, resulting in reduced sedation compared to first-generation antihistamines. This mechanism provides symptomatic relief of allergic rhinitis, urticaria, and other histamine-mediated allergic conditions.","oneSentence":"Cetirizine is a selective H1-receptor antagonist that blocks histamine-mediated allergic responses without significant central nervous system penetration.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:43:21.541Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic rhinitis (seasonal and perennial)"},{"name":"Chronic urticaria"},{"name":"Allergic conjunctivitis"}]},"trialDetails":[{"nctId":"NCT02604212","phase":"PHASE2","title":"A Multi-dose Study of ARC-520 in Patients With Hepatitis B 'e' Antigen (HBeAg) Positive, Chronic Hepatitis B Virus Infection","status":"TERMINATED","sponsor":"Arrowhead Pharmaceuticals","startDate":"2015-11","conditions":"Hepatitis B","enrollment":32},{"nctId":"NCT04175834","phase":"PHASE3","title":"Comparing Risk and Severity of IRRs in Patients Premedicated With Cetirizine vs. Diphenhydramine Prior to Ocrelizumab","status":"COMPLETED","sponsor":"Providence Health & Services","startDate":"2020-02-05","conditions":"Multiple Sclerosis, Infusion Reaction","enrollment":19},{"nctId":"NCT00974571","phase":"PHASE3","title":"Montelukast in Perennial Allergic Rhinitis - 2001-2002 Study (0476-246)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2001-11","conditions":"Perennial Allergic Rhinitis","enrollment":1365},{"nctId":"NCT02394106","phase":"PHASE2","title":"Ofatumumab in Children With Drug Resistant Idiopathic Nephrotic Syndrome","status":"TERMINATED","sponsor":"Istituto Giannina Gaslini","startDate":"2015-07","conditions":"Nephrotic Syndrome","enrollment":13},{"nctId":"NCT01916226","phase":"PHASE4","title":"A Comparator Study of Fluticasone Propionate Nasal Spray Verses (vs) Cetirizine in the Treatment of Seasonal Allergic Rhinitis","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2013-08-01","conditions":"Rhinitis, Allergic, Perennial and Seasonal","enrollment":682},{"nctId":"NCT01651871","phase":"PHASE2","title":"Combination Study Of S-555739/Cetirizine HCl In Adult Patients With Seasonal Allergic Rhinitis","status":"COMPLETED","sponsor":"Shionogi","startDate":"2012-07","conditions":"Seasonal Allergic Rhinitis","enrollment":779},{"nctId":"NCT00972504","phase":"PHASE2","title":"723/726 Proof of Concept Study in Allergen Challenge Chamber in Hannover","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2009-06-01","conditions":"Rhinitis, Allergic, Seasonal","enrollment":54},{"nctId":"NCT00851344","phase":"PHASE2","title":"Allergen Challenge Chamber Study With Single Dose Oral GSK835726 Compared With Placebo","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2008-09","conditions":"Rhinitis, Allergic, Seasonal","enrollment":54},{"nctId":"NCT00863902","phase":"PHASE1","title":"A Relative Bioavailability Study of Cetirizine HCl 10 mg Tablets Under Non-fasting Conditions","status":"COMPLETED","sponsor":"Actavis Inc.","startDate":"2006-08","conditions":"Healthy","enrollment":26},{"nctId":"NCT00864279","phase":"PHASE1","title":"A Relative Bioavailability Study of Cetirizine HCl 10 mg Tablets Under Fasting Conditions","status":"COMPLETED","sponsor":"Actavis Inc.","startDate":"2006-08","conditions":"Healthy","enrollment":26},{"nctId":"NCT00639587","phase":"PHASE3","title":"Efficacy and Safety of Cetirizine Tablets Versus Ketotifen Dry Syrup in Children With Perennial Allergic Rhinitis","status":"COMPLETED","sponsor":"UCB Pharma","startDate":"2002-08","conditions":"Rhinitis, Allergic, Perennial","enrollment":149}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":725,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Comparator: cetirizine","genericName":"Comparator: cetirizine","companyName":"Organon and Co","companyId":"organon-and-co","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cetirizine is a selective H1-receptor antagonist that blocks histamine-mediated allergic responses without significant central nervous system penetration. Used for Allergic rhinitis (seasonal and perennial), Chronic urticaria, Allergic conjunctivitis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}