{"id":"comparator-cefotetan","brandName":"Comparator: cefotetan","genericName":"Comparator: cefotetan","companyId":"merck","companyName":"Merck Sharp & Dohme LLC","phase":"phase_3","status":"active","modality":"Small molecule","aliases":[],"developmentCodes":[],"firstApprovalDate":null,"firstApprovalCountry":null,"aiSummary":"Cefotetan, developed by Merck Sharp & Dohme LLC, is a second-generation cephalosporin antibiotic used primarily for the prevention and treatment of surgical site infections. It has completed a Phase 3 trial comparing its efficacy to another marketed drug in colorectal surgery patients. The drug lacks an FDA label but has potential in the surgical infection market.","enrichmentLevel":3,"visitCount":0,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Cefotetan works by disrupting the cross-linking of peptidoglycan in the bacterial cell wall, leading to cell wall instability and bacterial death. It has broad-spectrum activity against gram-positive and gram-negative bacteria, including anaerobes, making it useful for surgical prophylaxis and mixed aerobic-anaerobic infections. The drug is bactericidal and typically administered intravenously or intramuscularly.","oneSentence":"Cefotetan is a second-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins.","_ai_confidence":"high"},"administration":{},"safety":{"commonSideEffects":[{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Hypersensitivity reactions"},{"rate":null,"effect":"Phlebitis at injection site"},{"rate":null,"effect":"Elevated liver enzymes"}]},"trials":[],"indications":{"approved":[{"name":"Surgical prophylaxis"},{"name":"Mixed aerobic-anaerobic infections"},{"name":"Gynecological infections"},{"name":"Intra-abdominal infections"}]},"commercial":null,"patents":[],"timeline":[],"rwe":[],"competitors":[],"ownershipHistory":[],"trialDetails":[],"genericFilers":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"labelChanges":[],"nice":null,"revenue":null,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}