{"id":"comparator-aprepitant","safety":{"commonSideEffects":[{"rate":"18","effect":"Fatigue"},{"rate":"9","effect":"Constipation"},{"rate":"8","effect":"Diarrhea"},{"rate":"9","effect":"Headache"},{"rate":"5","effect":"Hiccups"}]},"_chembl":{"chemblId":"CHEMBL4303169","moleculeType":"Small molecule","molecularWeight":"534.43"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Aprepitant crosses the blood-brain barrier and selectively antagonizes NK1 receptors, which are involved in the emetic pathway. By blocking substance P, a key neurotransmitter in nausea and vomiting, it provides antiemetic effects particularly effective against chemotherapy-induced nausea and vomiting (CINV). It is often used as part of a multimodal antiemetic regimen alongside 5-HT3 antagonists and corticosteroids.","oneSentence":"Aprepitant is a neurokinin-1 (NK1) receptor antagonist that blocks substance P signaling in the chemoreceptor trigger zone and vomiting center to prevent nausea and vomiting.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:06:49.874Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chemotherapy-induced nausea and vomiting (CINV) prevention in patients receiving highly emetogenic chemotherapy"},{"name":"Post-operative nausea and vomiting (PONV) prevention"}]},"trialDetails":[{"nctId":"NCT02861859","phase":"PHASE3","title":"Individualised Versus Standard Care for Breast Cancer Patients at High-risk for Chemotherapy-induced Nausea and Vomiting The ILIAD Study","status":"COMPLETED","sponsor":"Ottawa Hospital Research Institute","startDate":"2016-12","conditions":"Breast Cancer","enrollment":221},{"nctId":"NCT01697579","phase":"PHASE2","title":"Study of the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Fosaprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV) in Children (MK-0517-029)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2012-12-13","conditions":"Chemotherapy-induced Nausea and Vomiting","enrollment":240},{"nctId":"NCT01362530","phase":"PHASE3","title":"A Study of the Safety and Efficacy of Aprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV) in Pediatric Participants (MK-0869-208)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2011-09-13","conditions":"Chemotherapy Induced Nausea and Vomiting","enrollment":307},{"nctId":"NCT01732458","phase":"PHASE2","title":"A Study to Evaluate Aprepitant for the Prevention of Post-Operative Nausea and Vomiting in Children (MK-0869-219)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme 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Disorder","enrollment":495},{"nctId":"NCT00048607","phase":"PHASE3","title":"Treatment of Patients With Major Depressive Disorder With MK0869 (0869-062)(COMPLETED)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2002-07-30","conditions":"Major Depressive Disorder","enrollment":600},{"nctId":"NCT00035048","phase":"PHASE3","title":"Treatment of Patients With Major Depressive Disorder With MK0869 (0869-068)(COMPLETED)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2001-11-21","conditions":"Major Depressive Disorder","enrollment":540},{"nctId":"NCT00090155","phase":"PHASE3","title":"2 Doses of an Approved Drug Being Studied for a New Indication for the Prevention of Postoperative Nausea and Vomiting (0869-090)(COMPLETED)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2003-09-26","conditions":"Postoperative Nausea and Vomiting","enrollment":805},{"nctId":"NCT00042029","phase":"PHASE3","title":"Treatment of Patients With Major Depressive Disorder With MK0869 (0869-073)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2002-06-18","conditions":"Major Depressive Disorder","enrollment":324},{"nctId":"NCT00092183","phase":"PHASE4","title":"An Investigational Drug for the Prevention of Chemotherapy-Induced Nausea and Vomiting (MK-0869-071)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2002-10-10","conditions":"Nausea, Vomiting, Breast Neoplasms","enrollment":866},{"nctId":"NCT00048594","phase":"PHASE3","title":"Long Term Treatment of Patients With Major Depressive Disorder With MK0869 (0869-065)(COMPLETED)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2002-01-03","conditions":"Major Depressive Disorder","enrollment":800},{"nctId":"NCT00034983","phase":"PHASE3","title":"Treatment of Patients With Major Depressive Disorder With MK0869 (0869-066)(COMPLETED)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme 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Disorder","enrollment":584},{"nctId":"NCT00619359","phase":"PHASE3","title":"Evaluation of Fosaprepitant (MK0517) in Single Dose Schedule (0517-017)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2008-02","conditions":"Chemotherapy-Induced Nausea and Vomiting (CINV)","enrollment":2322},{"nctId":"NCT00231777","phase":"PHASE3","title":"A Study to Examine the Safety and Tolerability of MK0517 for the Prevention of Post-Operative Nausea and Vomiting (0517-015)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2005-07","conditions":"Post-Operative Nausea and Vomiting","enrollment":216},{"nctId":"NCT00035282","phase":"PHASE3","title":"Treatment of Patients With Major Depressive Disorder With MK0869 (0869-060)(COMPLETED)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2001-09","conditions":"Major Depressive Disorder","enrollment":450},{"nctId":"NCT00945321","phase":"PHASE1","title":"A Study to Assess the Bioequivalence of Aprepitant and Fosaprepitant and the Effect of Food on Aprepitant Bioavailability (0869-165)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2009-02","conditions":"Chemotherapy-Induced Nausea and Vomiting","enrollment":42},{"nctId":"NCT00835965","phase":"NA","title":"Oral Aprepitant and Lower Dose Dexamethasone Versus Aprepitant Alone for Preventing Postoperative Nausea and Vomiting (PONV) After Elective Laparoscopic Surgeries","status":"UNKNOWN","sponsor":"Main Line Health","startDate":"2009-02","conditions":"Nausea, Vomiting","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":455,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Comparator: Aprepitant","genericName":"Comparator: Aprepitant","companyName":"Merck Sharp & Dohme LLC","companyId":"merck-sharp-dohme-llc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Aprepitant is a neurokinin-1 (NK1) receptor antagonist that blocks substance P signaling in the chemoreceptor trigger zone and vomiting center to prevent nausea and vomiting. Used for Chemotherapy-induced nausea and vomiting (CINV) prevention in patients receiving highly emetogenic chemotherapy, Post-operative nausea and vomiting (PONV) prevention.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}