{"id":"commercially-available-lansoprazole","safety":{"commonSideEffects":[{"rate":"2-5%","effect":"Headache"},{"rate":"2-5%","effect":"Diarrhea"},{"rate":"2-5%","effect":"Nausea"},{"rate":"1-3%","effect":"Abdominal pain"},{"rate":"1-3%","effect":"Flatulence"}]},"_chembl":{"chemblId":"CHEMBL480","moleculeType":"Small molecule","molecularWeight":"369.37"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This results in a decrease in gastric acid production, which can help alleviate symptoms of gastroesophageal reflux disease (GERD) and other conditions associated with excessive acid production. Lansoprazole works by covalently binding to the H+/K+ ATPase enzyme, preventing it from pumping protons into the gastric lumen and thereby reducing gastric acid secretion.","oneSentence":"Lansoprazole is a proton pump inhibitor that reduces gastric acid secretion by irreversibly inhibiting the H+/K+ ATPase enzyme in the gastric parietal cells.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:06:47.810Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Erosive esophagitis"},{"name":"Gastroesophageal reflux disease (GERD)"},{"name":"Zollinger-Ellison syndrome"},{"name":"Duodenal ulcers"},{"name":"Helicobacter pylori eradication"}]},"trialDetails":[{"nctId":"NCT03015610","phase":"PHASE3","title":"Genotype-tailored Treatment of Symptomatic Acid-Reflux in Children With Uncontrolled Asthma","status":"COMPLETED","sponsor":"Jason Lang, M.D., M.P.H.","startDate":"2017-10-31","conditions":"Asthma, Gastroesophageal Reflux","enrollment":41}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["once daily"],"phase":"phase_3","status":"active","brandName":"commercially available lansoprazole","genericName":"commercially available lansoprazole","companyName":"Jason Lang, M.D., M.P.H.","companyId":"jason-lang-m-d-m-p-h","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lansoprazole is a proton pump inhibitor that reduces gastric acid secretion by irreversibly inhibiting the H+/K+ ATPase enzyme in the gastric parietal cells. Used for Erosive esophagitis, Gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}