{"id":"commercial-ibuprofen","safety":{"commonSideEffects":[{"rate":"5-15","effect":"Gastrointestinal upset (nausea, dyspepsia, abdominal pain)"},{"rate":"3-10","effect":"Heartburn"},{"rate":"1-3","effect":"Dizziness"},{"rate":"1-3","effect":"Rash"},{"rate":"0.5-1","effect":"Gastrointestinal bleeding (with chronic use)"},{"rate":"1-2","effect":"Cardiovascular events (with chronic use)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that non-selectively blocks COX-1 and COX-2 enzymes, which catalyze prostaglandin synthesis. By reducing prostaglandin levels in tissues, it suppresses inflammatory responses, alleviates pain signaling, and lowers body temperature set point. This mechanism makes it effective for mild to moderate pain and inflammatory conditions.","oneSentence":"Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce the production of prostaglandins, thereby decreasing inflammation, pain, and fever.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:06:55.842Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Mild to moderate pain"},{"name":"Fever reduction"},{"name":"Inflammation associated with headache, muscular aches, backache, minor arthritis pain, menstrual cramps, and common cold"}]},"trialDetails":[{"nctId":"NCT02735122","phase":"PHASE3","title":"Study of Acetaminophen (ACM) in Post-operative Dental Pain","status":"COMPLETED","sponsor":"Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division","startDate":"2016-04-30","conditions":"Post Operative Dental Pain","enrollment":420},{"nctId":"NCT02320708","phase":"PHASE2","title":"Study of Acetaminophen (ACE) in Post-operative Dental Pain","status":"COMPLETED","sponsor":"Johnson & Johnson Healthcare Products Division of McNEIL-PPC, Inc.","startDate":"2014-12-31","conditions":"Dental Pain","enrollment":240},{"nctId":"NCT03224403","phase":"PHASE3","title":"Randomized, Double-Blind, Single-Dose, Efficacy and Safety Study of Test Acetaminophen Tablet in Postoperative Dental Pain","status":"COMPLETED","sponsor":"Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division","startDate":"2017-07-19","conditions":"Post-operative Dental Pain","enrollment":664}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":16,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Commercial IBU"],"phase":"phase_3","status":"active","brandName":"Commercial ibuprofen","genericName":"Commercial ibuprofen","companyName":"Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division","companyId":"johnson-johnson-consumer-inc-mcneil-consumer-healthcare-division","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce the production of prostaglandins, thereby decreasing inflammation, pain, and fever. Used for Mild to moderate pain, Fever reduction, Inflammation associated with headache, muscular aches, backache, minor arthritis pain, menstrual cramps, and common cold.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}