{"id":"combogesic-tablets","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Dyspepsia"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL942","moleculeType":"Small molecule","molecularWeight":"361.40"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The combination leverages paracetamol's central analgesic and antipyretic effects alongside ibuprofen's peripheral anti-inflammatory action via COX inhibition. This dual mechanism allows for enhanced pain relief at lower individual doses, potentially reducing adverse effects compared to higher single-agent dosing while providing complementary therapeutic benefits for inflammatory pain conditions.","oneSentence":"Combogesic combines paracetamol and ibuprofen to provide analgesic and anti-inflammatory pain relief through dual inhibition of prostaglandin synthesis and central pain pathways.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:06:46.336Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute pain management"},{"name":"Postoperative pain"}]},"trialDetails":[{"nctId":"NCT07225140","phase":"PHASE3","title":"A Study of Combogesic® 325 in Adolescent Patients With Moderate to Severe Postoperative Pain Associated With Orthopedic Surgery","status":"NOT_YET_RECRUITING","sponsor":"AFT Pharmaceuticals, Ltd.","startDate":"2026-02","conditions":"Post Operative Pain, Acute","enrollment":180}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Acetaminophen 325 mg and ibuprofen 97.5 mg"],"phase":"phase_3","status":"active","brandName":"Combogesic® tablets","genericName":"Combogesic® tablets","companyName":"AFT Pharmaceuticals, Ltd.","companyId":"aft-pharmaceuticals-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Combogesic combines paracetamol and ibuprofen to provide analgesic and anti-inflammatory pain relief through dual inhibition of prostaglandin synthesis and central pain pathways. Used for Acute pain management, Postoperative pain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}