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The combination leverages synergistic sedative and analgesic effects for perioperative use.","oneSentence":"This combination drug pairs dexmedetomidine (an alpha-2 adrenergic agonist) with esketamine (an NMDA receptor antagonist) to produce sedation and analgesia with dissociative properties.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:41:04.711Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Perioperative sedation and analgesia"}]},"trialDetails":[{"nctId":"NCT07479602","phase":"PHASE4","title":"Intranasal Dexmedetomidine-esketamine Administration and Postoperative Pain in Pediatric Patients","status":"NOT_YET_RECRUITING","sponsor":"Peking University First Hospital","startDate":"2026-04","conditions":"Adenotonsillectomy, Children, Intranasal Administration","enrollment":160},{"nctId":"NCT07377981","phase":"PHASE4","title":"An Exploratory Study of the Efficacy and Safety of Esketamine and Dexmedetomidine in Non-Intubated ICU Patients 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