{"id":"combined-antioxidant-therapy","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This therapeutic approach combines multiple antioxidant agents to scavenge free radicals and enhance endogenous antioxidant defenses, thereby reducing cellular damage from oxidative stress. By targeting oxidative stress through synergistic mechanisms, the combination aims to provide broader protection against conditions where oxidative damage is pathogenic. The specific antioxidant agents and their targets within this combination are not publicly detailed.","oneSentence":"Combined antioxidant therapy works by neutralizing reactive oxygen species and reducing oxidative stress through multiple complementary antioxidant pathways.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:06:48.127Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[]},"trialDetails":[{"nctId":"NCT05713799","phase":"PHASE2","title":"Trial of the Combination of Alpha-Lipoic Acid and Mirabegron in Women and in Men With Obesity","status":"NOT_YET_RECRUITING","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"2026-04-01","conditions":"Insulin Resistance, Obesity","enrollment":60},{"nctId":"NCT07283900","phase":"PHASE2","title":"Ascorbate in Myelodysplastic Syndrome","status":"RECRUITING","sponsor":"Prajwal Dhakal","startDate":"2026-03-11","conditions":"Myelodysplastic Syndromes","enrollment":38},{"nctId":"NCT07177079","phase":"PHASE1","title":"High-dose Ascorbate (HDA) in Combination With Standard of Care Azacitidine and Venetoclax in Acute Myeloid Leukemia (AML)","status":"NOT_YET_RECRUITING","sponsor":"Kittika Poonsombudlert","startDate":"2026-05-31","conditions":"Acute Myeloid Leukemia","enrollment":30},{"nctId":"NCT07360639","phase":"PHASE1, PHASE2","title":"The Effectiveness of Herbal Creams Compared to Urea in Dry Skin Treatment","status":"COMPLETED","sponsor":"Universitas Syiah Kuala","startDate":"2025-06-01","conditions":"Dry Skin, Xerosis Cutis","enrollment":64},{"nctId":"NCT06362005","phase":"PHASE4","title":"The Efficacy of Selenium as an Alternative or Complementary Topical Treatment of Oral Lichen Planus","status":"COMPLETED","sponsor":"Al-Azhar University","startDate":"2024-05-01","conditions":"Lichen Planus, Oral","enrollment":50},{"nctId":"NCT07312123","phase":"NA","title":"A Study to See Whether Taking a Mix of Vitamins Can Help Adults Recover Better After Surgery for Carpal Tunnel Syndrome","status":"RECRUITING","sponsor":"Hospital Universiti Sains Malaysia","startDate":"2025-12-08","conditions":"Carpal Tunnel Syndrome","enrollment":84},{"nctId":"NCT05648630","phase":"NA","title":"Improving Exercise Rehabilitation Efficacy Outcomes Veterans Peripheral Artery Disease","status":"WITHDRAWN","sponsor":"VA Office of Research and Development","startDate":"2023-07-03","conditions":"Peripheral Artery Disease (D058729), Oxidative Stress (D018384), Inflammation (D007249)","enrollment":""},{"nctId":"NCT07182292","phase":"NA","title":"Effect of a Combined Exercise and Anti-Inflammatory Nutritional Intervention in Frail Older Adults","status":"NOT_YET_RECRUITING","sponsor":"Fundacion Miguel Servet","startDate":"2025-10-01","conditions":"Frail Elderly Syndrome, Malnutrition Elderly","enrollment":158},{"nctId":"NCT05373043","phase":"NA","title":"Long-term COVID and Rehabilitation","status":"RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2022-11-01","conditions":"Long-COVID","enrollment":300},{"nctId":"NCT07001150","phase":"PHASE2","title":"Role of Silymarin in Neuroprotection and Symptom Management in Parkinson's Disease","status":"RECRUITING","sponsor":"Tanta University","startDate":"2025-05-10","conditions":"Parkinson Disease","enrollment":50},{"nctId":"NCT07149961","phase":"NA","title":"Curcumin-Piperine Supplementation in STEMI - SPICE STEMI Trial","status":"COMPLETED","sponsor":"Universitas Diponegoro","startDate":"2025-02-05","conditions":"ST Elevation Myocardial Infarction (STEMI), Malondialdehyde, Hs-CRP","enrollment":50},{"nctId":"NCT05962957","phase":"PHASE2","title":"Role of Pentoxifylline and Celecoxib in Parkinsonism","status":"COMPLETED","sponsor":"Mostafa Bahaa","startDate":"2023-08-07","conditions":"Parkinson Disease","enrollment":80},{"nctId":"NCT07085637","phase":"NA","title":"IV Hydrogen Nanobubbles for Cardiac Function and QoL","status":"COMPLETED","sponsor":"Indonesia Molecule Institute","startDate":"2022-09-19","conditions":"Cardiovascular Diseases, Hypertension, Blood Pressure","enrollment":52},{"nctId":"NCT06836128","phase":"PHASE3","title":"The Combined Effect of N-Acetyl Cysteine and Metformin in Polycystic Ovary Syndrome Patients","status":"RECRUITING","sponsor":"Cairo University","startDate":"2025-03-01","conditions":"Polycystic Ovary Syndrome","enrollment":102},{"nctId":"NCT05614349","phase":"PHASE3","title":"Canadian Adaptive Platform Trial of Treatments for COVID-19 in Community Settings","status":"ACTIVE_NOT_RECRUITING","sponsor":"Unity Health Toronto","startDate":"2023-01-16","conditions":"COVID-19","enrollment":797},{"nctId":"NCT01550510","phase":"PHASE1, PHASE2","title":"Research Study of IV Vitamin C in Combination With Irinotecan vs Irinotecan Alone for Advanced Colorectal CA","status":"TERMINATED","sponsor":"Thomas Jefferson University","startDate":"2011-12","conditions":"Stage IV Colorectal Cancer","enrollment":4},{"nctId":"NCT01555489","phase":"PHASE2","title":"Assessing the Efficacy and Safety of IV Vitamin C in Combination With Standard Chemotherapy for Pancreatic Ca","status":"TERMINATED","sponsor":"Thomas Jefferson University","startDate":"2011-10","conditions":"Stage IV Pancreatic Cancer","enrollment":11},{"nctId":"NCT06875791","phase":"PHASE1, PHASE2","title":"Safety and Efficacy Trial of TV5M01 for Radiation-Induced Mucositis in Head and Neck Cancer Patients.","status":"NOT_YET_RECRUITING","sponsor":"Fundacion Clinica Valle del Lili","startDate":"2025-12-28","conditions":"Squamous Cell Carcinoma of the Head and Neck, Oral Mucositis","enrollment":40},{"nctId":"NCT06418347","phase":"PHASE3","title":"Effect of ALA Combined With Letrozole on Polycystic Ovary Syndrome Clinical Outcome in Infertile Females","status":"RECRUITING","sponsor":"Ain Shams University","startDate":"2024-04-01","conditions":"Polycystic Ovary Syndrome, Infertility, Female","enrollment":150},{"nctId":"NCT04959201","phase":"PHASE2","title":"Combination of NMDA-enhancing and Antioxidant Treatments for Schizophrenia","status":"RECRUITING","sponsor":"China Medical University Hospital","startDate":"2020-11-30","conditions":"Schizophrenia","enrollment":90},{"nctId":"NCT06759766","phase":"NA","title":"Evaluation of Antimicrobial Potency of Garlic Lemon Extract Irrigant Versus Physiological Saline Irrigant","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2025-01-01","conditions":"Necrotic Primary Teeth","enrollment":38},{"nctId":"NCT03684213","phase":"PHASE1","title":"Local Antioxidant Therapy Vasoconstriction Effects in Different Races","status":"COMPLETED","sponsor":"The University of Texas at Arlington","startDate":"2018-10-15","conditions":"Cardiovascular Diseases, Cardiovascular Risk Factor, Vasoconstriction","enrollment":22},{"nctId":"NCT06050031","phase":"","title":"Level of DNA-fragmentation Before and After Antioxidant-based Therapies in Male Infertility","status":"NOT_YET_RECRUITING","sponsor":"Janna Pape","startDate":"2024-05","conditions":"Infertility, Male","enrollment":78},{"nctId":"NCT06405243","phase":"PHASE3","title":"Myoinositol, L-arginine and Chromium With Letrozole for Ovulation Induction in Polycystic Ovarian Syndrome Patients","status":"NOT_YET_RECRUITING","sponsor":"Beni-Suef University","startDate":"2024-06-30","conditions":"Polycystic Ovary Syndrome","enrollment":100},{"nctId":"NCT06355765","phase":"","title":"Citicoline & Antioxidants in Glaucoma","status":"COMPLETED","sponsor":"University of Naples","startDate":"2022-01-10","conditions":"Glaucoma, Open-Angle","enrollment":60},{"nctId":"NCT02034422","phase":"NA","title":"Understanding the Exercise-Hypertension Paradox","status":"COMPLETED","sponsor":"VA Office of Research and Development","startDate":"2014-02-01","conditions":"Hypertension","enrollment":75},{"nctId":"NCT05215743","phase":"PHASE1","title":"Combined Antioxidant Therapy Against Myocardial Reperfusion Injury. Phase I Study.","status":"COMPLETED","sponsor":"University of Chile","startDate":"2022-08-09","conditions":"Acute Myocardial Infarction, Ischemia-reperfusion Injury, Reperfusion Injury, Myocardial","enrollment":18},{"nctId":"NCT05231980","phase":"PHASE2","title":"Efficacy of Pentoxifylline and Alpha Lipoic Acid in PCOS Resistant to Clomiphene Citrate","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2022-06-05","conditions":"Clomiphene Citrate, Resistant Ovary Syndrome, Polycystic Ovary Syndrome","enrollment":120},{"nctId":"NCT04021550","phase":"EARLY_PHASE1","title":"Improving 24-hour Blood Pressure in Obstructive Sleep Apnea","status":"WITHDRAWN","sponsor":"University of British Columbia","startDate":"2023-05","conditions":"Obstructive Sleep Apnea","enrollment":""},{"nctId":"NCT05646693","phase":"PHASE2","title":"Effect of Combined Antioxidant Therapy on Oxidative Stress Markers and Inflammatory Cytokines in Patients With Tinnitus","status":"UNKNOWN","sponsor":"University of Guadalajara","startDate":"2022-12-01","conditions":"Tinnitus, Subjective, Tinnitus, Bilateral, Antioxidant Therapy","enrollment":58},{"nctId":"NCT04234334","phase":"NA","title":"Benefits of Eggs in Combination With a Plant-based Diet","status":"COMPLETED","sponsor":"University of Connecticut","startDate":"2020-01-13","conditions":"Coronary Artery Disease, Diabetes, Metabolic Syndrome","enrollment":24},{"nctId":"NCT02588807","phase":"PHASE1","title":"Food Supplement for the Treatment of Patients With Amyotrophic Lateral Sclerosis","status":"WITHDRAWN","sponsor":"Herb Spirit","startDate":"2021-01-01","conditions":"Amyotrophic Lateral Sclerosis","enrollment":""},{"nctId":"NCT05429229","phase":"PHASE2","title":"Effect of Topical Antioxidants in Dry Eye Disease and Diabetic Retinopathy","status":"UNKNOWN","sponsor":"Adolfo Daniel Rodriguez-Carrizalez","startDate":"2021-11-01","conditions":"Dry Eye Syndromes, Diabetic Retinopathy, Oxidative Stress","enrollment":78},{"nctId":"NCT05397626","phase":"PHASE1","title":"Biofeedback and Hydrogen Water as Treatments for Chronic Fatigue Syndrome","status":"UNKNOWN","sponsor":"Stony Brook University","startDate":"2022-05-23","conditions":"Chronic Fatigue Syndrome","enrollment":39},{"nctId":"NCT05340634","phase":"PHASE4","title":"Evaluation of Metionac for the Modulation of Metabolic and Endocrine Parameters in Patients With PCOS.","status":"COMPLETED","sponsor":"Margan Biotech","startDate":"2020-04-20","conditions":"Polycystic Ovary Syndrome","enrollment":90},{"nctId":"NCT04071977","phase":"PHASE2","title":"Combined Antioxidant Therapy on Oxidative Stress in Aqueous and Vitreous Humor of Diabetic Retinopathy Patients","status":"COMPLETED","sponsor":"University of Guadalajara","startDate":"2020-03-25","conditions":"Diabetic Retinopathy, Oxidative Stress, Diabetes","enrollment":40},{"nctId":"NCT03702374","phase":"PHASE3","title":"Combined Antioxidant Therapy on Oxidative Stress, Mitochondrial Dysfunction Markers in Diabetic Retinopathy","status":"COMPLETED","sponsor":"University of Guadalajara","startDate":"2018-09-26","conditions":"Diabetic Retinopathy","enrollment":132},{"nctId":"NCT04783714","phase":"NA","title":"Investigating Effects of a Novel Nutraceutical on Hypercholesterolaemia in Australian Adults","status":"COMPLETED","sponsor":"Swisse Wellness Pty Ltd","startDate":"2021-04-30","conditions":"Hypercholesterolemia","enrollment":42},{"nctId":"NCT04575493","phase":"NA","title":"Clinical Efficacy of Crano-cure inTreatment of Urinary Tract Infection","status":"COMPLETED","sponsor":"Islamia University of Bahawalpur","startDate":"2020-10-05","conditions":"Urinary Tract Infections","enrollment":205},{"nctId":"NCT04835259","phase":"NA","title":"Efficacy of Topical Antioxidants in Tretment of Photoaging","status":"UNKNOWN","sponsor":"Sohag University","startDate":"2021-04","conditions":"Photoaging","enrollment":90},{"nctId":"NCT04713332","phase":"PHASE3","title":"Effectiveness of Vitamin E and Hydrogen-Rich Water on Radiation Therapy-Induced Adverse In Patients With Rectal Cancer","status":"UNKNOWN","sponsor":"University of Jordan","startDate":"2019-07-06","conditions":"Radiation-induced Injuries in Patients With Rectal Cancer","enrollment":60},{"nctId":"NCT04292314","phase":"PHASE2, PHASE3","title":"Hydroxy Urea, Omega 3, Nigella Sativa,Honey on Oxidative Stress and Iron Chelation in Pediatric Major Thalassemia","status":"COMPLETED","sponsor":"Beni-Suef University","startDate":"2019-11-01","conditions":"Iron Overload, Oxidative Stress, Thalassemia Major","enrollment":350},{"nctId":"NCT04308161","phase":"PHASE2","title":"Vitamin D Oral Gel for Prevention of Radiation Induced Oral Mucositis","status":"UNKNOWN","sponsor":"Hams Hamed Abdelrahman","startDate":"2019-11-02","conditions":"Oral Mucositis Due to Radiation","enrollment":45},{"nctId":"NCT03726450","phase":"NA","title":"Myo-inositol and an Antioxidant Mix for the Treatment of Vietnamese Infertile Men","status":"UNKNOWN","sponsor":"Andrology and Fertility Hospital of Hanoi","startDate":"2018-11-01","conditions":"Male Infertility","enrollment":55},{"nctId":"NCT04137627","phase":"PHASE3","title":"Melatonin Effect in Combination With Neoadjuvant Chemotherapy to Clinical Response in Locally Advanced Oral Squamous Cell Carcinoma","status":"COMPLETED","sponsor":"Indonesia University","startDate":"2017-07-04","conditions":"Oral Squamous Cell Carcinoma, Neoadjuvant Chemotherapy","enrollment":50},{"nctId":"NCT03833570","phase":"PHASE2","title":"Melatonin for Prevention of Radiation Induced Oral Mucositis","status":"COMPLETED","sponsor":"Hams Hamed Abdelrahman","startDate":"2018-01-12","conditions":"Oral Mucositis (Ulcerative) Due to Radiation","enrollment":40},{"nctId":"NCT02368457","phase":"PHASE4","title":"Management of Mandibular ORN: PENTO as Medical Treatment","status":"COMPLETED","sponsor":"Hospital Vall d'Hebron","startDate":"2016-02","conditions":"Osteoradionecrosis","enrollment":24},{"nctId":"NCT03442283","phase":"","title":"Meta-analysis of Randomized Controlled Trials on Vitamins and Mineral Supplementation for CVD Prevention and Treatment","status":"UNKNOWN","sponsor":"University of Toronto","startDate":"2016-07","conditions":"Cardiovascular Diseases","enrollment":1},{"nctId":"NCT00844792","phase":"PHASE2","title":"Study of Antioxidants on Prostate Tumors in Men Undergoing Radical Prostatectomy for Prostate Cancer","status":"COMPLETED","sponsor":"University Health Network, Toronto","startDate":"2008-10","conditions":"Cancer of the Prostate, Prostate Cancer, Prostatic Neoplasms","enrollment":48},{"nctId":"NCT02902315","phase":"NA","title":"Antioxidants Combined With Cryotherapy on Inflammatory Response After Resistance Exercise in Untrained Volunteers","status":"COMPLETED","sponsor":"Universidade Federal de Santa Maria","startDate":"2017-01-04","conditions":"Inflammation, Oxidative Stress, Pain","enrollment":26},{"nctId":"NCT00565214","phase":"NA","title":"Effect of Supplementary Vitamins on Oxidant Gene Expression in the Lungs of Healthy Smokers","status":"COMPLETED","sponsor":"Weill Medical College of Cornell University","startDate":"2007-09","conditions":"Chronic Obstructive Pulmonary Disease (COPD)","enrollment":46},{"nctId":"NCT03026569","phase":"NA","title":"Orange Juice Consumption in Patients With Hepatitis C","status":"COMPLETED","sponsor":"São Paulo State University","startDate":"2012-05","conditions":"Chronic Infection","enrollment":43},{"nctId":"NCT02752555","phase":"NA","title":"Severe Male Factor Infertility Management","status":"UNKNOWN","sponsor":"Benha University","startDate":"2016-04","conditions":"Oligoasthenoteratozoospermia","enrollment":60},{"nctId":"NCT00116207","phase":"PHASE3","title":"An Intervention Trial for Cardiac Neuropathy in Type 1 Diabetes","status":"COMPLETED","sponsor":"University of Michigan","startDate":"2000-01","conditions":"Diabetic Autonomic Neuropathy","enrollment":44},{"nctId":"NCT00286403","phase":"PHASE2, PHASE3","title":"Vasodilators and Anti-Oxidant Therapy in Early ATN","status":"WITHDRAWN","sponsor":"Southeast Renal Research Institute","startDate":"2008-08","conditions":"Acute Renal Failure","enrollment":""},{"nctId":"NCT02174393","phase":"NA","title":"Microneedling Plus the Universal Peel For Acne Scarring","status":"COMPLETED","sponsor":"Englewood Hospital and Medical Center","startDate":"2014-07","conditions":"Acne Scarring","enrollment":15},{"nctId":"NCT02630862","phase":"NA","title":"Oxidative Stress and Oxysterols Profiling in Patients With Carotid Revascularization","status":"COMPLETED","sponsor":"University of Roma La Sapienza","startDate":"2010-09","conditions":"Carotid Stenosis, Cardiovascular Disease, Atherosclerosis","enrollment":240},{"nctId":"NCT02629536","phase":"PHASE3","title":"Effect on Migraine Frequency of Combined Anti-oxidant Therapy: The MIGRANT Study.","status":"UNKNOWN","sponsor":"University of Notre Dame Australia","startDate":"2016-03","conditions":"Migraine, Headaches","enrollment":90},{"nctId":"NCT01329770","phase":"PHASE2","title":"Safety and Efficacy Study of Antioxidants for the Treatment of the Fragile X Syndrome","status":"COMPLETED","sponsor":"Yolanda de Diego Otero","startDate":"2010-12","conditions":"Fragile X Syndrome","enrollment":30},{"nctId":"NCT02215525","phase":"PHASE3","title":"Treatment of Chronic HCV Infected Egyptian Patients With Electromagnetic Waves and Herbal Therapy","status":"UNKNOWN","sponsor":"Egyptian Military Medical Services","startDate":"2014-04","conditions":"Hepatitis C","enrollment":160},{"nctId":"NCT02062034","phase":"PHASE2","title":"Efficacy of Ubiquinone and Combined Antioxidant Therapy in Non-proliferative Diabetic Retinopathy","status":"COMPLETED","sponsor":"University of Guadalajara","startDate":"2011-02","conditions":"Non-proliferative Diabetic Retinopathy, Diabetes Mellitus Type 2","enrollment":61},{"nctId":"NCT00426348","phase":"PHASE4","title":"A Study of the Antioxidant Probucol Combined With Valsartan in Patients With IgA Nephropathy","status":"COMPLETED","sponsor":"Guangdong Provincial People's Hospital","startDate":"2007-05","conditions":"Glomerulonephritis, IGA Nephropathy","enrollment":75},{"nctId":"NCT01050621","phase":"PHASE1, PHASE2","title":"Trial of Chemotherapy Plus Intravenous Vitamin C in Patients With Advanced Cancer for Whom Chemotherapy Alone is Only Marginally Effective","status":"COMPLETED","sponsor":"Jewish General Hospital","startDate":"2010-01","conditions":"Cancer","enrollment":14},{"nctId":"NCT01704794","phase":"PHASE1, PHASE2","title":"Quality of Life Study for Sickle Cell Patients Treated With Jobelyn (Sorghum Bicolor Extract)","status":"UNKNOWN","sponsor":"Lagos State University","startDate":"2013-04","conditions":"Other Sickle-cell Disorders With Crisis, Unspecified","enrollment":96},{"nctId":"NCT01152931","phase":"PHASE3","title":"Antioxidant Micronutrients in Malaria","status":"COMPLETED","sponsor":"University of Lagos, Nigeria","startDate":"2010-08","conditions":"Malaria","enrollment":10},{"nctId":"NCT00983164","phase":"NA","title":"Blood Antioxidant Status in Chronic Hepatitis C Patients Before and After Antioxidant Supplementation: a Randomized Clinical Trial","status":"COMPLETED","sponsor":"Universidade do Sul de Santa Catarina","startDate":"2007-01","conditions":"Hepatitis C, Oxidative Stress","enrollment":32}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":25,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Drusen Laz","lutein","zeaxanthin","astaxanthin","vitamin C"],"phase":"phase_3","status":"active","brandName":"Combined antioxidant therapy","genericName":"Combined antioxidant therapy","companyName":"University of Guadalajara","companyId":"university-of-guadalajara","modality":"Small molecule","firstApprovalDate":"","aiSummary":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":3,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}