{"id":"combination-tranilast-and-febuxostat","safety":{"commonSideEffects":[{"rate":"10%","effect":"Diarrhea"},{"rate":"8%","effect":"Nausea"},{"rate":"6%","effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Tranilast works by blocking the PDGF receptors, which are involved in the proliferation and migration of smooth muscle cells. Febuxostat, on the other hand, inhibits xanthine oxidase, an enzyme involved in the production of uric acid.","oneSentence":"Tranilast is a selective inhibitor of PDGF receptors, while Febuxostat is a xanthine oxidase inhibitor.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T03:27:25.639Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Gout, Malignant hypertension"}]},"trialDetails":[{"nctId":"NCT00995618","phase":"PHASE2","title":"Study of Tranilast Alone or in Combination With Febuxostat in Patients With Hyperuricemia","status":"COMPLETED","sponsor":"Nuon Therapeutics, Inc.","startDate":"2009-09","conditions":"Gout, Hyperuricemia","enrollment":24}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"Combination - Tranilast and Febuxostat","genericName":"Combination - Tranilast and Febuxostat","companyName":"Nuon Therapeutics, Inc.","companyId":"nuon-therapeutics-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tranilast is a selective inhibitor of PDGF receptors, while Febuxostat is a xanthine oxidase inhibitor. Used for Gout, Malignant hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}