{"id":"combination-tranilast-and-allopurinol","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Diarrhea"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Dizziness"},{"rate":"5-10%","effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Tranilast is a mast cell stabilizer that inhibits the release of histamine and other mediators from mast cells, which are involved in allergic reactions and inflammation. Allopurinol, on the other hand, is a xanthine oxidase inhibitor that reduces the production of uric acid, which is associated with gout and other conditions.","oneSentence":"Tranilast inhibits the activity of mast cells and platelets, while Allopurinol inhibits xanthine oxidase.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T03:27:29.571Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Gout"},{"name":"Allergic rhinitis"}]},"trialDetails":[{"nctId":"NCT01109121","phase":"PHASE2","title":"Tranilast Plus Allopurinol in Patients With Moderate to Severe Gout (TAnGO)","status":"COMPLETED","sponsor":"Nuon Therapeutics, Inc.","startDate":"2010-06","conditions":"Moderate to Severe Gout, Hyperuricemia","enrollment":112},{"nctId":"NCT01052987","phase":"PHASE2","title":"Study of Tranilast Alone or in Combination With Allopurinol in Subjects With Hyperuricemia","status":"COMPLETED","sponsor":"Nuon Therapeutics, Inc.","startDate":"2010-01","conditions":"Gout, Hyperuricemia","enrollment":24}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"Combination - Tranilast and Allopurinol","genericName":"Combination - Tranilast and Allopurinol","companyName":"Nuon Therapeutics, Inc.","companyId":"nuon-therapeutics-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tranilast inhibits the activity of mast cells and platelets, while Allopurinol inhibits xanthine oxidase. Used for Gout, Allergic rhinitis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}