{"id":"comarum-palustre","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Comarum palustre (marsh cinquefoil) is a traditional medicinal plant used in Russian and Eastern European folk medicine. The preparation contains polyphenols, tannins, and other plant-derived compounds that are believed to have immunomodulatory and anti-inflammatory properties. The exact molecular mechanisms remain incompletely characterized in modern pharmacological terms.","oneSentence":"Comarum palustre is a herbal preparation that modulates immune function through its bioactive phytochemical constituents.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:30:31.983Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Immunodeficiency conditions"},{"name":"Inflammatory and autoimmune disorders"}]},"trialDetails":[{"nctId":"NCT03530930","phase":"PHASE4","title":"Comarum Palustre in Knee Osteoarthritis and Diabetes","status":"COMPLETED","sponsor":"Federal State Budgetary Scientific Institution, Research Institute of Fundamental and Clinical Immunology","startDate":"2018-06-29","conditions":"Osteoarthritis, Diabetes Mellitus","enrollment":15}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Potentilla palustris"],"phase":"marketed","status":"active","brandName":"Comarum Palustre","genericName":"Comarum Palustre","companyName":"Federal State Budgetary Scientific Institution, Research Institute of Fundamental and Clinical Immunology","companyId":"federal-state-budgetary-scientific-institution-research-institute-of-fundamental","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Comarum palustre is a herbal preparation that modulates immune function through its bioactive phytochemical constituents. Used for Immunodeficiency conditions, Inflammatory and autoimmune disorders.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}