{"id":"collagen-pvp","safety":{"commonSideEffects":[]},"_chembl":{"chemblId":"CHEMBL5095161","moleculeType":"Enzyme"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The collagen component serves as a natural extracellular matrix scaffold that facilitates cell adhesion and tissue formation, while the PVP (polyvinylpyrrolidone) acts as a biocompatible polymer that enhances the material's physical properties, stability, and bioavailability. This combination is designed to support hemostasis, wound closure, and tissue repair through both structural and biological mechanisms.","oneSentence":"Collagen-PVP is a composite biomaterial that combines collagen with polyvinylpyrrolidone to provide structural support and promote tissue regeneration and wound healing.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:45:08.997Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Wound healing and tissue regeneration"}]},"trialDetails":[{"nctId":"NCT06656169","phase":"PHASE1, PHASE2","title":"Effect of Subcutaneous Polyvidone Collagen Treatment on Hand Recovery in Adult Rheumatoid Arthritis.","status":"COMPLETED","sponsor":"Instituto Mexicano del Seguro Social","startDate":"2021-01-01","conditions":"Arthritis, Rheumatoid","enrollment":25},{"nctId":"NCT06585319","phase":"PHASE2, PHASE3","title":"Pirfenidone LP or Collagen-polyvinylpyrrolidone in COVID-19","status":"COMPLETED","sponsor":"Materno-Perinatal Hospital of the State of Mexico","startDate":"2020-02-01","conditions":"COVID 19","enrollment":36},{"nctId":"NCT06396819","phase":"PHASE4","title":"Collagen-povidone for Diabetic Seniors' Tenosynovitis","status":"COMPLETED","sponsor":"Instituto Mexicano del Seguro Social","startDate":"2023-01-01","conditions":"Diabetes Complications","enrollment":25},{"nctId":"NCT06275880","phase":"NA","title":"Intraarticular Collagen in Patients With Gonarthrosis","status":"COMPLETED","sponsor":"Instituto Mexicano del Seguro Social","startDate":"2023-04-01","conditions":"Gonarthrosis","enrollment":130},{"nctId":"NCT05946005","phase":"PHASE4","title":"Lidocaine, Povidone Iodine, and Honey Application on Second-degree Perineal Tear Healing","status":"COMPLETED","sponsor":"Hasanuddin University","startDate":"2021-12-01","conditions":"Perineal Tear","enrollment":200},{"nctId":"NCT04517162","phase":"PHASE1, PHASE2","title":"Intramuscular Effect of Polymerized Type I Collagen on the Cytokine Storm in COVID-19 Patients","status":"UNKNOWN","sponsor":"Janette Furuzawa Carballeda","startDate":"2020-08-19","conditions":"Covid19, Cytokine Storm, Regulation of Inflammatory Response","enrollment":90},{"nctId":"NCT04019782","phase":"PHASE3","title":"Collagen-PVP vs Hylan G-F 20 in the Treatment of Knee Osteoarthritis","status":"UNKNOWN","sponsor":"Coordinación de Investigación en Salud, Mexico","startDate":"2019-08-01","conditions":"Knee Osteoarthritis, Gonarthrosis","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":20,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Fibroquel"],"phase":"phase_3","status":"active","brandName":"Collagen-PVP","genericName":"Collagen-PVP","companyName":"Coordinación de Investigación en Salud, Mexico","companyId":"coordinaci-n-de-investigaci-n-en-salud-mexico","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Collagen-PVP is a solution used in clinical trials for various conditions, including diabetes complications, perineal tear, and COVID-19, as well as a treatment for stenosing tenosynovitis in older adults with type 2 diabetes. It is an enzyme modality that targets a specific protease, likely related to its action on gliadin, based on its synonyms listed in ChEMBL.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}