{"id":"colistin-polymyxin-b-sulbactam","safety":{"commonSideEffects":[{"rate":null,"effect":"Nephrotoxicity"},{"rate":null,"effect":"Neurotoxicity (paresthesias, dizziness)"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Fever"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Colistin and polymyxin B are cationic cyclic peptides that bind to and disrupt the outer membrane of gram-negative bacteria, causing cell lysis and death. Sulbactam is a β-lactamase inhibitor that protects β-lactam antibiotics from enzymatic degradation and has intrinsic antibacterial activity. This combination targets multidrug-resistant organisms, particularly Acinetobacter baumannii and Pseudomonas aeruginosa.","oneSentence":"Colistin and polymyxin B disrupt bacterial cell membranes while sulbactam inhibits bacterial β-lactamases, together providing broad-spectrum activity against multidrug-resistant gram-negative bacteria.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:19:29.149Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Multidrug-resistant gram-negative bacterial infections (Acinetobacter baumannii, Pseudomonas aeruginosa)"},{"name":"Hospital-acquired and ventilator-associated pneumonia caused by resistant organisms"}]},"trialDetails":[{"nctId":"NCT07326540","phase":"PHASE3","title":"Efficacy and Safety of BV100 Plus Low Dose Polymyxin B Versus Colistin Plus High-dose Ampicillin/Sulbactam in Patients With Hospital-acquired or Ventilator-associated Bacterial Pneumonia Due to Carbapenem-resistant Acinetobacter Baumannii-calcoaceticus Complex","status":"NOT_YET_RECRUITING","sponsor":"BioVersys SAS","startDate":"2026-03-20","conditions":"Hospital Acquired Bacterial Pneumonia (HABP), Ventilator Associated Bacterial Pneumonia (VABP), Colistin Resistanrt ABC","enrollment":248},{"nctId":"NCT07004049","phase":"PHASE4","title":"Optimising TREATment for Severe Gram-Negative Bacterial Infections","status":"RECRUITING","sponsor":"National University of Singapore","startDate":"2025-04-21","conditions":"Bloodstream Infection, Ventilator Associated Bacterial Pneumonia, Hospital Acquired Bacterial Pneumonia","enrollment":600},{"nctId":"NCT03894046","phase":"PHASE3","title":"Study to Evaluate the Efficacy and Safety of Intravenous Sulbactam-ETX2514 in the Treatment of Patients With Infections Caused by Acinetobacter Baumannii-calcoaceticus Complex","status":"COMPLETED","sponsor":"Entasis Therapeutics","startDate":"2019-09-05","conditions":"Acinetobacter Baumannii-calcoaceticus Complex, Hospital-acquired Bacterial Pneumonia, Ventilator-associated Bacterial Pneumonia","enrollment":207},{"nctId":"NCT02099240","phase":"EARLY_PHASE1","title":"Patients Response to Early Switch To Oral:Osteomyelitis Study","status":"TERMINATED","sponsor":"Julio Ramirez","startDate":"2014-03-06","conditions":"Osteomyelitis","enrollment":11}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Colistin/Polymyxin B + Sulbactam","genericName":"Colistin/Polymyxin B + Sulbactam","companyName":"National University of Singapore","companyId":"national-university-of-singapore","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Colistin and polymyxin B disrupt bacterial cell membranes while sulbactam inhibits bacterial β-lactamases, together providing broad-spectrum activity against multidrug-resistant gram-negative bacteria. Used for Multidrug-resistant gram-negative bacterial infections (Acinetobacter baumannii, Pseudomonas aeruginosa), Hospital-acquired and ventilator-associated pneumonia caused by resistant organisms.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}