{"id":"colistimethate-sodium-for-injection","safety":{"commonSideEffects":[{"rate":null,"effect":"Nephrotoxicity (acute kidney injury)"},{"rate":null,"effect":"Neurotoxicity (paresthesia, dizziness)"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Fever"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Colistimethate sodium (also known as colistin methanesulfonate) is converted in vivo to colistin, a polymyxin antibiotic. Colistin acts as a cationic detergent that interacts with the outer membrane of gram-negative bacteria, disrupting membrane integrity and causing leakage of cellular contents. It is primarily used against multidrug-resistant gram-negative pathogens, particularly Pseudomonas aeruginosa and Acinetobacter baumannii.","oneSentence":"Colistimethate sodium is a prodrug of colistin that disrupts bacterial cell membranes by binding to lipopolysaccharides and phospholipids, leading to cell lysis and death.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:06:41.216Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Infections caused by multidrug-resistant gram-negative bacteria (e.g., Pseudomonas aeruginosa, Acinetobacter baumannii)"},{"name":"Hospital-acquired pneumonia and other serious infections in patients with limited treatment options"}]},"trialDetails":[{"nctId":"NCT06051513","phase":"NA","title":"Efficacy and Safety of Colistimethate Sodium for Injection in The Treatment of Carbapenem-Resistant Enterobacteriaceae Infection","status":"RECRUITING","sponsor":"Southeast University, China","startDate":"2023-11-27","conditions":"Carbapenem-Resistant Enterobacteriaceae Infection","enrollment":404},{"nctId":"NCT06893835","phase":"PHASE4","title":"Comparative Study of Clinical Outcomes and Safety Between Colistin and Tigecycline","status":"ACTIVE_NOT_RECRUITING","sponsor":"Beni-Suef University","startDate":"2024-12-01","conditions":"Infection in ICU","enrollment":132},{"nctId":"NCT06198764","phase":"PHASE3","title":"A Clinical Trial for the Treatment of Carbapenem Resistant Gram-negative Bacterial Infection With Colistimethate Sodium for Injection","status":"RECRUITING","sponsor":"Chia Tai Tianqing Pharmaceutical Group Co., Ltd.","startDate":"2023-07-06","conditions":"Mental Health Issue","enrollment":80},{"nctId":"NCT03397914","phase":"PHASE4","title":"Effect of Different Colistin Doses on Clinical Outcome of Pediatric Cancer Patients With Gram Negative Infections","status":"COMPLETED","sponsor":"National Cancer Institute, Egypt","startDate":"2017-01","conditions":"Gram-Negative Bacterial Infections, Pediatric Cancer, Colistin","enrollment":70}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Colistimethate sodium for injection","genericName":"Colistimethate sodium for injection","companyName":"Chia Tai Tianqing Pharmaceutical Group Co., Ltd.","companyId":"chia-tai-tianqing-pharmaceutical-group-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Colistimethate sodium is a prodrug of colistin that disrupts bacterial cell membranes by binding to lipopolysaccharides and phospholipids, leading to cell lysis and death. Used for Infections caused by multidrug-resistant gram-negative bacteria (e.g., Pseudomonas aeruginosa, Acinetobacter baumannii), Hospital-acquired pneumonia and other serious infections in patients with limited treatment options.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}