{"id":"colextran","rwe":[{"pmid":"37367171","year":"2023","title":"Bile Acid Sequestrants Based on Natural and Synthetic Gels.","finding":"","journal":"Gels (Basel, Switzerland)","studyType":"Clinical Study"}],"tags":[{"label":"colextran","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C10AC03","category":"atc"},{"label":"Active","category":"status"},{"label":"Hyperlipidemia","category":"indication"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"dextran 2-(diethylamino)ethyl ether","offLabel":[],"synonyms":["colextran","dextran 2-(diethylamino)ethyl ether","colextran hydrochloride","colextran HCl"],"timeline":[],"approvals":[],"brandName":"Dextran 2-(Diethylamino)Ethyl Ether","ecosystem":[{"indication":"Hyperlipidemia","otherDrugs":[{"name":"cholestyramine","slug":"cholestyramine","company":"Bristol Myers"},{"name":"choline fenofibrate","slug":"choline-fenofibrate","company":"Abbvie"},{"name":"clofibrate","slug":"clofibrate","company":""},{"name":"colestipol","slug":"colestipol","company":"Pharmacia And Upjohn"}],"globalPrevalence":390000000}],"mechanism":{"modality":"Small Molecule","drugClass":"colextran","explanation":"Imagine Colextran as a magnet that attracts and removes excess cholesterol from the blood, helping to lower cholesterol levels and reduce the risk of heart disease. This process is not fully understood, but it is thought to occur through a combination of Colextran's chemical structure and its interaction with cholesterol molecules in the bloodstream.","oneSentence":"Colextran works by binding to and removing excess cholesterol from the bloodstream.","technicalDetail":"Colextran's exact mechanism of action is unknown, but it is believed to involve the formation of a complex between Colextran and cholesterol, leading to the removal of excess cholesterol from the bloodstream."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4852","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=COLEXTRAN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:16:53.137144","biosimilars":[],"competitors":[{"drugName":"cholestyramine","drugSlug":"cholestyramine","fdaApproval":"1973-08-03","genericCount":17,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"colestipol","drugSlug":"colestipol","fdaApproval":"1977-04-04","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"colesevelam","drugSlug":"colesevelam","fdaApproval":"2000-05-26","genericCount":15,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"colextran","indications":{"approved":[{"name":"Hyperlipidemia","source":"DrugCentral","snomedId":55822004,"regulator":"FDA","usPrevalence":null,"globalPrevalence":390000000,"prevalenceMethod":"curated","prevalenceSource":"WHO, 2023"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"cholestyramine","brandName":"cholestyramine","genericName":"cholestyramine","approvalYear":"1973","relationship":"same-class"},{"drugId":"colestipol","brandName":"colestipol","genericName":"colestipol","approvalYear":"1977","relationship":"same-class"},{"drugId":"colesevelam","brandName":"colesevelam","genericName":"colesevelam","approvalYear":"2000","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UMLSCUI":"C3652645","ChEMBL_ID":"CHEMBL2108241","KEGG_DRUG":"D07744","PUBCHEM_CID":"230181"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":1,"therapeuticAreas":["Metabolic"],"atcClassification":{"source":"DrugCentral","atcCode":"C10AC03","allCodes":["C10AC03"]},"biosimilarFilings":[],"recentPublications":[{"date":"2023 Jun 19","pmid":"37367171","title":"Bile Acid Sequestrants Based on Natural and Synthetic Gels.","journal":"Gels (Basel, Switzerland)"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Dextran 2-(Diethylamino)Ethyl Ether, also known as Colextran, is a small molecule drug in the colextran class. Its exact mechanism of action is unknown, but it is used to treat Hyperlipidemia. Colextran's commercial status is unclear, and it may be patented or off-patent. As a pharmaceutical professional, it is essential to note that Colextran's safety considerations and pharmacokinetic properties are not well-documented.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}