{"id":"cold-blood-based-cardioplegia","safety":{"commonSideEffects":[{"rate":null,"effect":"Myocardial stunning"},{"rate":null,"effect":"Reperfusion injury"},{"rate":null,"effect":"Arrhythmias post-operatively"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This cardioplegic solution combines cold temperature with electrolyte composition (typically high potassium) to stop the heart's electrical and mechanical activity, reducing myocardial oxygen demand during surgical procedures. The hypothermia provides metabolic protection to cardiac tissue, while the chemical composition maintains electrolyte balance and prevents reperfusion injury when normal circulation is restored.","oneSentence":"Cold blood-based cardioplegia is a solution used during cardiac surgery to induce cardiac arrest and protect the heart from ischemic injury by rapidly cooling and chemically arresting myocardial function.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:29:21.932Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Myocardial protection during cardiac surgery requiring cardiopulmonary bypass"}]},"trialDetails":[{"nctId":"NCT04094168","phase":"PHASE4","title":"Clinical Impact of Del Nido Cardioplegia in Adult Cardiac Surgery","status":"COMPLETED","sponsor":"JESSICA GARCIA SUAREZ","startDate":"2018-06-15","conditions":"Heart; Surgery, Heart, Functional Disturbance as Result","enrollment":474}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["CARDIBRAUN"],"phase":"marketed","status":"active","brandName":"COLD BLOOD BASED CARDIOPLEGIA","genericName":"COLD BLOOD BASED CARDIOPLEGIA","companyName":"JESSICA GARCIA SUAREZ","companyId":"jessica-garcia-suarez","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cold blood-based cardioplegia is a solution used during cardiac surgery to induce cardiac arrest and protect the heart from ischemic injury by rapidly cooling and chemically arresting myocardial function. Used for Myocardial protection during cardiac surgery requiring cardiopulmonary bypass.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}