{"id":"colchicine-pill","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Diarrhea"},{"rate":"5-15","effect":"Nausea"},{"rate":"5-15","effect":"Abdominal pain"},{"rate":"1-5","effect":"Myopathy"},{"rate":"1-5","effect":"Peripheral neuropathy"}]},"_chembl":{"chemblId":"CHEMBL107","moleculeType":"Small molecule","molecularWeight":"399.44"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Colchicine binds to beta-tubulin and prevents microtubule assembly, which disrupts cell division and inflammatory cell movement. This mechanism reduces the recruitment of neutrophils and other immune cells to sites of inflammation, and decreases the production of pro-inflammatory cytokines like IL-1β and TNF-α. The drug has been used for centuries in gout and is now approved for acute gout flares and familial Mediterranean fever.","oneSentence":"Colchicine inhibits microtubule polymerization by binding to tubulin, thereby suppressing inflammatory cell migration and reducing production of inflammatory mediators.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:30:24.718Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute gout flares"},{"name":"Familial Mediterranean fever (FMF)"},{"name":"Gout prophylaxis"}]},"trialDetails":[{"nctId":"NCT05850091","phase":"PHASE4","title":"Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Intervention With Statin and Colchicine","status":"RECRUITING","sponsor":"Massachusetts General Hospital","startDate":"2023-12-07","conditions":"Coronary Artery Disease","enrollment":200},{"nctId":"NCT07232069","phase":"PHASE3","title":"PRE-EMPT: Prospective RandomizEd Evaluation and Management of Premature aTherosclerosis","status":"NOT_YET_RECRUITING","sponsor":"Duke University","startDate":"2026-07-01","conditions":"Coronary Artery Disease Risk Factors Multiple, Coronary Artery Disease Progression, Prevention & Control","enrollment":1500},{"nctId":"NCT05855746","phase":"PHASE3","title":"Colchicine Versus Placebo in Acute Myocarditis Patients","status":"RECRUITING","sponsor":"Assistance Publique - 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Hôpitaux de Paris","startDate":"2010-05","conditions":"Renal Replacement Therapies","enrollment":17}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":12,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Colchicine","Colchicine 0.5 MG","group C"],"phase":"marketed","status":"active","brandName":"Colchicine Pill","genericName":"Colchicine Pill","companyName":"Brigham and Women's Hospital","companyId":"brigham-and-women-s-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Colchicine inhibits microtubule polymerization by binding to tubulin, thereby suppressing inflammatory cell migration and reducing production of inflammatory mediators. Used for Acute gout flares, Familial Mediterranean fever (FMF), Gout prophylaxis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":3,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}