{"id":"colchicine-for-3-months","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Diarrhea"},{"rate":"5-15","effect":"Nausea"},{"rate":"5-15","effect":"Abdominal pain"},{"rate":"1-5","effect":"Myopathy"},{"rate":"1-5","effect":"Peripheral neuropathy"},{"rate":"1-3","effect":"Leukopenia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Colchicine binds to β-tubulin and prevents microtubule assembly, which disrupts cell division and inflammatory cell movement. This mechanism reduces the recruitment of neutrophils and other immune cells to sites of inflammation, and decreases the production of pro-inflammatory cytokines such as IL-1β and TNF-α. The anti-inflammatory effect makes it useful in conditions characterized by acute inflammatory flares.","oneSentence":"Colchicine inhibits microtubule polymerization by binding to tubulin, thereby suppressing inflammatory cell migration and reducing production of inflammatory mediators.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:06:38.233Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute gout flares"},{"name":"Familial Mediterranean fever"},{"name":"Pericarditis"},{"name":"Behçet's disease"}]},"trialDetails":[{"nctId":"NCT06130059","phase":"PHASE2","title":"Efficacy of LoDoCo in Improving Exercise Capacity Among Patients With HFpEF and Inflammation","status":"RECRUITING","sponsor":"University of Texas Southwestern Medical Center","startDate":"2024-04-24","conditions":"Heart Failure, Inflammation","enrollment":60},{"nctId":"NCT06396858","phase":"PHASE4","title":"Anti-inflammatory and Anti-thrombotic Therapy With colcHicine and Low 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Atherosclerosis","enrollment":410},{"nctId":"NCT05890664","phase":"PHASE3","title":"Colchicine After Electrocardioversion for Atrial Fibrillation","status":"RECRUITING","sponsor":"University Hospital, Basel, Switzerland","startDate":"2024-04-14","conditions":"Atrial Fibrillation, Cardiac Arrhythmia","enrollment":416},{"nctId":"NCT06837623","phase":"PHASE3","title":"Role of Colchicine as Anti-Inflammatory Therapy in HFpEF","status":"ACTIVE_NOT_RECRUITING","sponsor":"Cairo University","startDate":"2024-07-01","conditions":"HFpEF - Heart Failure With Preserved Ejection Fraction","enrollment":75},{"nctId":"NCT03913442","phase":"PHASE4","title":"Colchicine for the Treatment of Osteoarthritis of the Knee","status":"COMPLETED","sponsor":"NYU Langone Health","startDate":"2019-05-15","conditions":"Osteoarthritis, Osteo Arthritis Knee","enrollment":120},{"nctId":"NCT03635957","phase":"PHASE4","title":"Study of Pegloticase (KRYSTEXXA®) Plus Methotrexate in Patients With Uncontrolled 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Participants With Gout and Renal Impairment","status":"TERMINATED","sponsor":"Ironwood Pharmaceuticals, Inc.","startDate":"2017-07-19","conditions":"Gout, Chronic Kidney Disease (CKD)","enrollment":242},{"nctId":"NCT02282098","phase":"PHASE3","title":"Colchicine in Atrial Fibrillation to Prevent Stroke","status":"COMPLETED","sponsor":"Population Health Research Institute","startDate":"2014-11","conditions":"Atrial Fibrillation, Stroke","enrollment":80},{"nctId":"NCT04377321","phase":"","title":"Colchicine Has Anti-diabetic Effect","status":"COMPLETED","sponsor":"Ministry of Health and Population, Egypt","startDate":"2019-10-10","conditions":"Treatment Adherence","enrollment":150},{"nctId":"NCT01112982","phase":"PHASE4","title":"An Assessment of Chronic Synovial-Based Inflammation and Its Role With Serum Urate Levels.","status":"COMPLETED","sponsor":"University of South Florida","startDate":"2010-05","conditions":"Gout","enrollment":74},{"nctId":"NCT03659058","phase":"NA","title":"Impact of Ursodeoxycholic Acid, Silymarin, Antioxidants and Colchicine on Fibrosis Regression in HCV After SVR","status":"COMPLETED","sponsor":"Zagazig University","startDate":"2016-03-02","conditions":"Fibrosis, Liver","enrollment":400},{"nctId":"NCT02139046","phase":"PHASE3","title":"Efficacy and Safety of Extended Release and Immediate Release Febuxostat in Participants With Gout","status":"COMPLETED","sponsor":"Takeda","startDate":"2014-04","conditions":"Gout","enrollment":1790},{"nctId":"NCT02128490","phase":"PHASE2","title":"Efficacy and Safety of Extended Release and Immediate Release Febuxostat in Participants With Gout and Moderate Renal Impairment","status":"COMPLETED","sponsor":"Takeda","startDate":"2014-05","conditions":"Gout, Moderate Renal Impairment","enrollment":189},{"nctId":"NCT02021084","phase":"NA","title":"The Effect of Probiotics on Response to Therapy and on Adverse Effect in Patients Treated With Colchicine for Familial Mediterranean Fever.","status":"WITHDRAWN","sponsor":"Rambam Health Care Campus","startDate":"2013-12","conditions":"Familial Mediterranean Fever (FMF )","enrollment":""},{"nctId":"NCT00582907","phase":"PHASE2","title":"Rilonacept for Treatment of Familial Mediterranean Fever (FMF)","status":"COMPLETED","sponsor":"The Cleveland Clinic","startDate":"2008-08","conditions":"Familial Mediterranean Fever","enrollment":14},{"nctId":"NCT00128453","phase":"PHASE3","title":"Study of Colchicine to Treat Acute Pericarditis and Prevent Recurrences","status":"COMPLETED","sponsor":"Azienda Sanitaria Locale 3, Torino","startDate":"2005-08","conditions":"Pericarditis","enrollment":240},{"nctId":"NCT00723268","phase":"PHASE2","title":"Evaluation of Therapeutic Effect of 0.5 mg Colchicine and 5 mg Prednisolone on Oral Aphthae","status":"UNKNOWN","sponsor":"Mashhad University of Medical Sciences","startDate":"2007-05","conditions":"Oral Aphthae","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":37,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Colchicine (for 3 months)","genericName":"Colchicine (for 3 months)","companyName":"Azienda Sanitaria Locale 3, Torino","companyId":"azienda-sanitaria-locale-3-torino","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Colchicine inhibits microtubule polymerization by binding to tubulin, thereby suppressing inflammatory cell migration and reducing production of inflammatory mediators. Used for Acute gout flares, Familial Mediterranean fever, Pericarditis.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}