{"id":"colchicine-for-1-month","safety":{"commonSideEffects":[{"rate":"10–30","effect":"Diarrhea"},{"rate":"5–15","effect":"Nausea"},{"rate":"5–10","effect":"Abdominal pain"},{"rate":"1–5","effect":"Myopathy"},{"rate":"1–3","effect":"Peripheral neuropathy"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Colchicine binds to β-tubulin and prevents microtubule assembly, which disrupts cell division and inflammatory cell movement. This mechanism reduces the recruitment of neutrophils and other immune cells to sites of inflammation, and decreases the production of pro-inflammatory cytokines such as IL-1β and TNF-α. The drug has been used for decades in gout and is now being investigated for broader anti-inflammatory indications.","oneSentence":"Colchicine inhibits microtubule polymerization by binding to tubulin, thereby suppressing inflammatory cell migration and reducing production of inflammatory mediators.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:06:38.255Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute gout flare prophylaxis and treatment"},{"name":"Familial Mediterranean fever"},{"name":"Pericarditis (post-myocardial infarction or recurrent)"},{"name":"Cardiovascular inflammation (investigational)"}]},"trialDetails":[{"nctId":"NCT07476625","phase":"NA","title":"Efficacy and Safety of Thalidomide for Pediatric PFAPA Syndrome","status":"NOT_YET_RECRUITING","sponsor":"Wenjie Zheng","startDate":"2026-04-01","conditions":"Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis 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Renal Impairment","status":"TERMINATED","sponsor":"Ironwood Pharmaceuticals, Inc.","startDate":"2017-07-19","conditions":"Gout, Chronic Kidney Disease (CKD)","enrollment":242},{"nctId":"NCT04377321","phase":"","title":"Colchicine Has Anti-diabetic Effect","status":"COMPLETED","sponsor":"Ministry of Health and Population, Egypt","startDate":"2019-10-10","conditions":"Treatment Adherence","enrollment":150},{"nctId":"NCT01112982","phase":"PHASE4","title":"An Assessment of Chronic Synovial-Based Inflammation and Its Role With Serum Urate Levels.","status":"COMPLETED","sponsor":"University of South Florida","startDate":"2010-05","conditions":"Gout","enrollment":74},{"nctId":"NCT02500641","phase":"PHASE4","title":"Intensive Urate Lowering Therapy of Febuxostat Compared to Allopurinol on Cardiovascular Risk in Patients With Gout","status":"COMPLETED","sponsor":"Menarini International Operations Luxembourg 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and on Adverse Effect in Patients Treated With Colchicine for Familial Mediterranean Fever.","status":"WITHDRAWN","sponsor":"Rambam Health Care Campus","startDate":"2013-12","conditions":"Familial Mediterranean Fever (FMF )","enrollment":""},{"nctId":"NCT02095522","phase":"NA","title":"COlchicine Improve EnDothElial Function in Non ST Elevation Myocardial Infarction Patients","status":"WITHDRAWN","sponsor":"Tel-Aviv Sourasky Medical Center","startDate":"2014-03","conditions":"NSTEMI","enrollment":""},{"nctId":"NCT01552187","phase":"PHASE3","title":"COlchicine for Prevention of the Post-pericardiotomy Syndrome and Post-operative Atrial Fibrillation (COPPS-2 Trial)","status":"UNKNOWN","sponsor":"Maria Vittoria Hospital","startDate":"2012-03","conditions":"Cardiac Surgery, Post-pericardiotomy Syndrome, Atrial Fibrillation","enrollment":360},{"nctId":"NCT01080131","phase":"PHASE3","title":"Canakinumab in the Treatment of Acute Gout Flares and Prevention of New Flares in Patients Unable to 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Syndrome","enrollment":169}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":24,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Colchicine (for 1 month)","genericName":"Colchicine (for 1 month)","companyName":"Azienda Sanitaria Locale 3, Torino","companyId":"azienda-sanitaria-locale-3-torino","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Colchicine inhibits microtubule polymerization by binding to tubulin, thereby suppressing inflammatory cell migration and reducing production of inflammatory mediators. Used for Acute gout flare prophylaxis and treatment, Familial Mediterranean fever, Pericarditis (post-myocardial infarction or recurrent).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}