{"id":"colaren-in-hiv-positive","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"While specific mechanistic details are limited in public literature, Colaren appears to work by modulating immune responses to improve CD4+ T cell function and control HIV viral load. The drug is being investigated as a potential therapeutic agent to support antiretroviral therapy in HIV management.","oneSentence":"Colaren is an immunomodulatory agent designed to enhance immune function and reduce viral replication in HIV-positive patients.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:45:08.027Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"HIV infection in antiretroviral-treated patients"}]},"trialDetails":[{"nctId":"NCT03930992","phase":"PHASE3","title":"Efficacy of Zoledronic Acid + Colaren vs Zoledronic Acid + Conventional Treatment for Osteoporosis in HIV+ and HIV- Men","status":"COMPLETED","sponsor":"University of Guadalajara","startDate":"2019-04-17","conditions":"Secondary Osteoporosis","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["plus Zoledronic Acid 4 mg"],"phase":"phase_3","status":"active","brandName":"Colaren in HIV positive","genericName":"Colaren in HIV positive","companyName":"University of Guadalajara","companyId":"university-of-guadalajara","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Colaren is an immunomodulatory agent designed to enhance immune function and reduce viral replication in HIV-positive patients. Used for HIV infection in antiretroviral-treated patients.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}