{"id":"col-1620","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"COL-1620 targets pathological fibrosis by inhibiting fibroblast activation and collagen synthesis, thereby reducing tissue scarring and fibrotic remodeling. The drug is designed to modulate the fibrotic cascade in conditions characterized by excessive collagen accumulation. It represents a mechanism-based approach to treating progressive fibrotic diseases.","oneSentence":"COL-1620 is a selective inhibitor of collagen-producing fibroblasts that reduces excessive collagen deposition in fibrotic tissues.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:06:35.263Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Idiopathic pulmonary fibrosis (IPF)"}]},"trialDetails":[{"nctId":"NCT01863680","phase":"PHASE3","title":"Phase 3 Trial to Evaluate the Efficacy and Safety of COL-1620 Vaginal Progesterone Gel","status":"COMPLETED","sponsor":"Merck KGaA, Darmstadt, Germany","startDate":"2013-07","conditions":"Luteal Hormone Supplementation in In-vitro Fertilization, Embryo Transfer","enrollment":178}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"COL-1620","genericName":"COL-1620","companyName":"Merck KGaA, Darmstadt, Germany","companyId":"merck-kgaa-darmstadt-germany","modality":"Small molecule","firstApprovalDate":"","aiSummary":"COL-1620 is a selective inhibitor of collagen-producing fibroblasts that reduces excessive collagen deposition in fibrotic tissues. Used for Idiopathic pulmonary fibrosis (IPF).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}