{"id":"cobalamin","rwe":[{"pmid":"41905540","year":"2026","title":"Vitamin B12 Attenuates Post-Ischemic Brain Fibrotic Remodeling and Suppresses MAPK1 Signaling in Male Rats.","finding":"","journal":"Brain research bulletin","studyType":"Clinical Study"},{"pmid":"41891996","year":"2026","title":"Thiamine and Micronutrient Deficiencies in Hospitalized Veterans Without Alcohol Use Disorder.","finding":"","journal":"Diseases (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"41890422","year":"2026","title":"Encephalitis-like presentation of methylmalonic acidemia with homocystinuria in a postpartum woman: a case report.","finding":"","journal":"Frontiers in psychiatry","studyType":"Clinical Study"},{"pmid":"41885699","year":"2026","title":"Impact of blood donation on serum cobalamin and folic acid concentrations in dogs.","finding":"","journal":"Australian veterinary journal","studyType":"Clinical Study"},{"pmid":"41851124","year":"2026","title":"Seasonal frost improves probiotic and nutrient availability in fermented vegetables.","finding":"","journal":"NPJ science of food","studyType":"Clinical Study"}],"_fda":{"id":"d9913eda-a019-4227-9dd3-9e8358dec165","set_id":"06508e37-5ae6-4a17-bf60-b3828c6082a7","openfda":{"nui":["N0000193618","M0001797"],"upc":["0105420121004"],"unii":["PQ6CK8PD0R","6SO6U10H04","568ET80C3D","8406EY2OQA","935E97BOY8","25X51I8RD4","68Y4CF58BV","TLM2976OFR","8K0I04919X","K72I3DEX9B"],"route":["ORAL"],"spl_id":["d9913eda-a019-4227-9dd3-9e8358dec165"],"brand_name":["Dialyvite with Zinc"],"spl_set_id":["06508e37-5ae6-4a17-bf60-b3828c6082a7"],"package_ndc":["10542-012-10","10542-012-02"],"product_ndc":["10542-012"],"generic_name":["ASCORBIC ACID, THIAMINE, RIBOFLAVIN, NIACINAMIDE, PYRIDOXINE, FOLIC ACID, COBALAMIN, BIOTIN, PANTOTHENIC ACID, ZINC"],"product_type":["HUMAN PRESCRIPTION DRUG"],"pharm_class_cs":["Ascorbic Acid [CS]"],"substance_name":["ASCORBIC ACID","BIOTIN","CALCIUM PANTOTHENATE","COBALAMIN","FOLIC ACID","NIACINAMIDE","PYRIDOXINE HYDROCHLORIDE","RIBOFLAVIN","THIAMINE MONONITRATE","ZINC CITRATE"],"pharm_class_epc":["Vitamin C [EPC]"],"manufacturer_name":["Hillestad Pharmaceuticals USA"],"is_original_packager":[true]},"version":"5","description":["DESCRIPTION Dialyvite with Zinc is a prescription folic acid supplement with zinc and additional nutrients for kidney dialysis patients. Dialyvite with Zinc is a small, round, yellow, clear-coated tablet, with debossed \"H\" on one side. Each tablet contains: Folic Acid.....1 mg Vitamin C (Ascorbic Acid).....100 mg Thiamine (Thiamine Mononitrate).....1.5 mg Riboflavin.....1.7 mg Niacinamide.....20 mg Vitamin B6 (Pyridoxine HCl).....10 mg Vitamin B12 (Methylcobalamin).....6 mcg Biotin.....300 mcg Pantothenic Acid (Calcium Pantothenate).....10 mg Zinc (Zinc Citrate).....50 mg Inactive ingredients: Microcrystalline Cellulose, Croscarmellose Sodium, Mono-and Diglycerides, Pharmaceutical Glaze, Starch, Calcium Stearate."],"precautions":["PRECAUTIONS Folic acid supplementation may obscure pernicious anemia, in that hematologic remission can occur while neurological manifestations progress. Keep out of reach of children."],"effective_time":"20260127","adverse_reactions":["ADVERSE REACTIONS Allergic sensitizations have been reported following oral administration of folic acid. Consult your physician immediately if adverse side effects occur."],"contraindications":["CONTRAINDICATIONS This product is contraindicated in patients with known hypersensitivity to any of the ingredients."],"indications_and_usage":["INDICATIONS AND USAGE Dialyvite with Zinc is a prescription folic acid supplement with Zinc and additional nutrients indicated for use in improving the nutritional status of renal dialysis patients."],"dosage_and_administration":["DOSAGE AND ADMINISTRATION Take one tablet per day or as directed by your physician, orally."],"spl_product_data_elements":["Dialyvite with Zinc Ascorbic Acid, Thiamine, Riboflavin, Niacinamide, Pyridoxine, Folic Acid, Cobalamin, Biotin, Pantothenic Acid, Zinc Ascorbic Acid Ascorbic Acid Thiamine Mononitrate Thiamine Ion Thiamine Riboflavin Riboflavin Niacinamide Niacinamide Pyridoxine Hydrochloride Pyridoxine Folic Acid Folic Acid Cobalamin Cobalamin Biotin Biotin Calcium Pantothenate Pantothenic Acid Zinc Citrate Zinc Cation Microcrystalline Cellulose Croscarmellose Sodium Glyceryl Monostearate Shellac Starch, Corn Calcium Stearate H"],"package_label_principal_display_panel":["PRINCIPAL DISPLAY PANEL NDC 10542-012-10 Dialyvite with Zinc Multivitamin Supplement for Dialysis Patients 100 Tablets Dialyvite with Zinc PDP"]},"tags":[{"label":"cobalamin","category":"class"},{"label":"Peptide","category":"modality"},{"label":"Oral","category":"route"},{"label":"Capsule","category":"form"},{"label":"Tablet","category":"form"},{"label":"Active","category":"status"},{"label":"Cobalamin deficiency","category":"indication"},{"label":"Pernicious anemia","category":"indication"},{"label":"Prevention of Vitamin B12 Deficiency","category":"indication"},{"label":"Toxic effect of cyanide","category":"indication"}],"phase":"marketed","safety":{"boxedWarnings":[],"commonSideEffects":[{"effect":"allergic and idiosyncratic reactions","drugRate":"reported","severity":"unknown"},{"effect":"glucose abnormalities","drugRate":"reported","severity":"unknown"},{"effect":"visual problems","drugRate":"reported","severity":"unknown"},{"effect":"gastrointestinal complaints","drugRate":"reported","severity":"unknown"},{"effect":"skin ailments","drugRate":"reported","severity":"unknown"}],"contraindications":["Atrophic gastritis","Gastrectomy","Hypertensive disorder","Hypokalemia","Leber's optic atrophy"],"specialPopulations":{"Paediatric use":"Not for pediatric use."}},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=COBALAMIN","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:30:00.889802+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:30:06.447623+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=COBALAMIN","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:30:06.978685+00:00"},"mechanism.drugClass":{"url":"https://api.fda.gov/drug/label.json","method":"deterministic","source":"FDA Label (EPC)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:29:59.647087+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:29:59.647122+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (no boxed warning)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:29:59.647130+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL4297272/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:30:07.685989+00:00"}},"allNames":["cobalamin","cobalamine"],"offLabel":[],"synonyms":["cobalamin","cobalamine"],"timeline":[],"approvals":[{"date":"","orphan":false,"company":"","regulator":"FDA"}],"ecosystem":[{"indication":"Cobalamin deficiency","otherDrugs":[{"name":"cyanocobalamin","slug":"cyanocobalamin","company":""},{"name":"hydroxocobalamin","slug":"hydroxocobalamin","company":"Watson Labs"},{"name":"thiamine","slug":"thiamine","company":"Hospira"}],"globalPrevalence":null},{"indication":"Pernicious anemia","otherDrugs":[{"name":"cyanocobalamin","slug":"cyanocobalamin","company":""},{"name":"hydroxocobalamin","slug":"hydroxocobalamin","company":"Watson Labs"},{"name":"thiamine","slug":"thiamine","company":"Hospira"}],"globalPrevalence":null},{"indication":"Prevention of Vitamin B12 Deficiency","otherDrugs":[{"name":"cobamamide","slug":"cobamamide","company":""},{"name":"cyanocobalamin","slug":"cyanocobalamin","company":""},{"name":"folic acid","slug":"folic-acid","company":"Lederle"},{"name":"hydroxocobalamin","slug":"hydroxocobalamin","company":"Watson Labs"}],"globalPrevalence":null},{"indication":"Toxic effect of cyanide","otherDrugs":[{"name":"amyl nitrite","slug":"amyl-nitrite","company":""},{"name":"hydroxocobalamin","slug":"hydroxocobalamin","company":"Watson Labs"},{"name":"sodium nitrite","slug":"sodium-nitrite","company":"Hope Pharms"},{"name":"sodium thiosulfate","slug":"sodium-thiosulfate","company":"Us Army"}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"Vitamin C [EPC]","explanation":"","oneSentence":"","technicalDetail":"Cobalamin plays a crucial role in the methylation of homocysteine to methionine, the synthesis of methylmalonyl-CoA to succinyl-CoA, and the metabolism of fatty acids and amino acids, particularly in the nervous system and red blood cells."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4603","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=COBALAMIN","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=COBALAMIN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:15:08.068250","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T00:30:25.592031+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[],"genericName":"cobalamin","indications":{"approved":[{"name":"Cobalamin deficiency","source":"DrugCentral","snomedId":190634004,"regulator":"FDA","eligibility":"renal dialysis patients"},{"name":"Pernicious anemia","source":"DrugCentral","snomedId":84027009,"regulator":"FDA","eligibility":"renal dialysis patients"},{"name":"Prevention of Vitamin B12 Deficiency","source":"DrugCentral","snomedId":"","regulator":"FDA","eligibility":"renal dialysis patients"},{"name":"Toxic effect of cyanide","source":"DrugCentral","snomedId":66207005,"regulator":"FDA","eligibility":"not specified"}],"offLabel":[{"name":"Methylmalonic acidemia","source":"DrugCentral","drugName":"COBALAMIN","evidenceCount":352,"evidenceLevel":"strong"}],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT05385042","phase":"NA","title":"Iron and Immune Response to Vaccine (IRONMUM)","status":"COMPLETED","sponsor":"University of Oxford","startDate":"2022-06-18","conditions":["Pregnancy Related"],"enrollment":171,"completionDate":"2025-07-22"},{"nctId":"NCT00078078","phase":"","title":"Clinical and Laboratory Study of Methylmalonic Acidemia","status":"RECRUITING","sponsor":"National Human Genome Research Institute (NHGRI)","startDate":"2004-06-07","conditions":["Organic Acidemia","Methylmalonic Acidemia","Inborn Errors of Metabolism"],"enrollment":2275,"completionDate":""},{"nctId":"NCT07487610","phase":"","title":"Relationship Between Neuropathic Pain and Geriatric Assessment Parameters in Patients Aged 80 Years and Older","status":"RECRUITING","sponsor":"Sultan 1. Murat State Hospital","startDate":"2026-03-17","conditions":["Neuropathic Pain","Old Age; Debility","Pain"],"enrollment":450,"completionDate":"2026-06-30"},{"nctId":"NCT07486141","phase":"NA","title":"Effect of Vitamin D and Folic Acid on Mild Cognitive Impairment","status":"ACTIVE_NOT_RECRUITING","sponsor":"Capital Medical University","startDate":"2024-11-01","conditions":["Mild Cognitive Impairment"],"enrollment":380,"completionDate":"2026-06"},{"nctId":"NCT06969716","phase":"","title":"Frequency of Fibromyalgia Syndrome in Elderly Patients Aged 80 and Above and Its Relationship With Geriatric Parameters","status":"COMPLETED","sponsor":"Sultan 1. Murat State Hospital","startDate":"2025-05-01","conditions":["Fibromyalgia","Old Age; Debility"],"enrollment":420,"completionDate":"2026-03-03"},{"nctId":"NCT07480369","phase":"NA","title":"Vegan Diet and Immune-Inflammatory Outcomes in Asthma and Healthy Adults","status":"NOT_YET_RECRUITING","sponsor":"Medical University of Gdansk","startDate":"2026-03","conditions":["Asthma","Dietary Intervention","Vegan Diet"],"enrollment":280,"completionDate":"2029-09-30"},{"nctId":"NCT05372445","phase":"NA","title":"Microbiome and Health Indicators in People With Obesity, Prediabetes and Type 2 Diabetes Undergoing a Lifestyle Intervention","status":"TERMINATED","sponsor":"National Council of Scientific and Technical Research, Argentina","startDate":"2022-05-30","conditions":["Diabetes Mellitus, Type 2","Obesity","PreDiabetes"],"enrollment":468,"completionDate":"2025-07-31"},{"nctId":"NCT07475546","phase":"PHASE3","title":"Combination Gerotherapeutic Interventions for Healthspan Improvement","status":"ACTIVE_NOT_RECRUITING","sponsor":"AgelessRx","startDate":"2025-07-23","conditions":["Healthspan Improvement","Aging","Longevity"],"enrollment":30,"completionDate":"2026-04"},{"nctId":"NCT07469189","phase":"PHASE1","title":"A Study on Hydroxocobalamin Given to Healthy Individual to Monitor Symptoms","status":"COMPLETED","sponsor":"Brigham and Women's Hospital","startDate":"2023-01-02","conditions":["Hydroxocobalamin Adverse Reaction"],"enrollment":10,"completionDate":"2023-06-30"},{"nctId":"NCT05751187","phase":"PHASE2","title":"Pembrolizumab Plus Bevacizumab and Chemotherapy for Non-Squamous NSCLC Patients","status":"ACTIVE_NOT_RECRUITING","sponsor":"Shanghai Chest Hospital","startDate":"2023-06-27","conditions":["Non-squamous NSCLC"],"enrollment":54,"completionDate":"2027-12-30"},{"nctId":"NCT06654089","phase":"PHASE4","title":"A Study Evaluating Quality of Life Parameters Following Use of Emergen-C","status":"COMPLETED","sponsor":"HALEON","startDate":"2024-10-30","conditions":["Dietary Supplements"],"enrollment":299,"completionDate":"2025-02-24"},{"nctId":"NCT04040023","phase":"NA","title":"Patient Blood Management in Cardiac Surgery","status":"COMPLETED","sponsor":"Clinique Pasteur","startDate":"2019-09-10","conditions":["Surgical Blood Loss"],"enrollment":900,"completionDate":"2021-09-23"},{"nctId":"NCT06979180","phase":"NA","title":"A Clinical Trial to Investigate the Safety and Efficacy of Papillex® on Abnormal Cervical Cells Caused by HPV.","status":"RECRUITING","sponsor":"Papillex Inc.","startDate":"2026-03","conditions":["CIN - Cervical Intraepithelial Neoplasia","CIN 1","CIN 2","HPV","Cervical Cells"],"enrollment":60,"completionDate":"2026-12"},{"nctId":"NCT07004465","phase":"NA","title":"Effectiveness of Vitamin b12 Versus Kenalog on Traumatic Ulcer Associated With Orthodontic Treatment","status":"COMPLETED","sponsor":"Hawraa Ali Abdullah","startDate":"2025-08-19","conditions":["Mouth Ulcer"],"enrollment":82,"completionDate":"2026-02-28"},{"nctId":"NCT07443410","phase":"NA","title":"Microbiological and Clinical Effects of Pre- and Probiotics in Non-Surgical Periodontal Therapy","status":"RECRUITING","sponsor":"University Hospital Heidelberg","startDate":"2024-10-25","conditions":["Periodontitis, Adult","Periodontitis (Stage 3)","Periodontitis Stage IV"],"enrollment":60,"completionDate":"2026-10"},{"nctId":"NCT06100146","phase":"NA","title":"Effectiveness of Fortification With Folic Acid and Vitamin B12 Among Teenage Girls","status":"COMPLETED","sponsor":"University Ghent","startDate":"2023-09-06","conditions":["Folate Deficiency","Vitamin B 12 Deficiency","Anemia, Megaloblastic","Cognitive Development","Depressive Symptoms"],"enrollment":472,"completionDate":"2024-08-31"},{"nctId":"NCT06697626","phase":"NA","title":"Validation of a Novel Functional Food Designed to Meet the Nutritional Needs of People Living With Parkinson's Disease","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Ulster","startDate":"2024-11-14","conditions":["Constipation","Parkinson Disease"],"enrollment":56,"completionDate":"2026-11"},{"nctId":"NCT07425093","phase":"NA","title":"Investigation of the Relationship Between Gray and White Matter Volumes, Walking Exercise, and Body Fat Percentage in Adults With a Body Mass Index Above 25","status":"COMPLETED","sponsor":"Amasya University","startDate":"2024-01-01","conditions":["Obesity & Overweight","Headache","Sedentary Lifestyle","Body Fat Percentage","Brain Grey Matter","Brain White Matter"],"enrollment":22,"completionDate":"2024-03-01"},{"nctId":"NCT06429007","phase":"PHASE1","title":"A Safety and Feasibility Trial Protocol of Metformin in Infants After Perinatal Brain Injury","status":"ENROLLING_BY_INVITATION","sponsor":"Boston Children's Hospital","startDate":"2025-10-01","conditions":["Hypoxic-Ischemic Encephalopathy","HIE","Neurodevelopment","Infant Development"],"enrollment":30,"completionDate":"2029-03-01"},{"nctId":"NCT07398885","phase":"NA","title":"Assessing the Impact of Herbal Supplement on Fatigue and Disease Activity in SLE: Results From an 8-Week Randomized Trial","status":"COMPLETED","sponsor":"University Tunis El Manar","startDate":"2024-07-01","conditions":["System; Lupus Erythematosus"],"enrollment":59,"completionDate":"2025-05-07"},{"nctId":"NCT02662504","phase":"PHASE2","title":"Intrapleural Photodynamic Therapy in a Multimodal Treatment for Patients With Malignant Pleural Mesothelioma","status":"COMPLETED","sponsor":"University Hospital, Lille","startDate":"2016-01-16","conditions":["Malignant Pleural Mesothelioma"],"enrollment":6,"completionDate":"2018-03-13"},{"nctId":"NCT05426395","phase":"PHASE1","title":"Vitamin B12 Dose Escalation Trial in Pregnancy","status":"ACTIVE_NOT_RECRUITING","sponsor":"George Washington University","startDate":"2023-06-05","conditions":["Vitamin B 12 Deficiency"],"enrollment":50,"completionDate":"2026-12"},{"nctId":"NCT07385144","phase":"NA","title":"A Study of a Dietary Supplement on Serum Biomarkers in Children","status":"RECRUITING","sponsor":"SF Research Institute, Inc.","startDate":"2026-01-30","conditions":["Nutritional Status","Serum Biomarkers"],"enrollment":30,"completionDate":"2026-03-05"},{"nctId":"NCT07380438","phase":"NA","title":"A Clinical Study to Evaluate the Efficacy of a Nutritional Supplement to Improve Carotenoid Content as Measured by a Non-invasive Hyperspectral Absorption Device","status":"COMPLETED","sponsor":"Pharmanex","startDate":"2025-10-20","conditions":["Nutrition Assessment"],"enrollment":84,"completionDate":"2026-01-08"},{"nctId":"NCT04150042","phase":"PHASE1","title":"SHARON: A Clinical Trial for Metastatic Cancer Using Chemotherapy and Patients' Own Stem Cells","status":"RECRUITING","sponsor":"General Oncology, Inc.","startDate":"2021-01-13","conditions":["Pancreatic Adenocarcinoma Metastatic","BRCA1 Mutation","BRCA2 Mutation","Pancreatic Acinar Cell Carcinoma","Pancreatic Ductal Adenocarcinoma","Pancreatic Cancer","Metastatic Pancreatic Cancer","Metastatic Pancreatic Ductal Adenocarcinoma","Breast Cancer Metastatic","Breast Cancer Stage IV","Pancreatic Cancer Stage IV","HER2-negative Breast Cancer","HER2 Negative Breast Carcinoma","Adenocarcinoma of the Breast","PALB2 Gene Mutation","Pancreas Cancer, Metastatic","Pancreas Cancer, Recurrent","Pancreas Cancer","Stage IV Pancreatic Cancer","Stage 4 Pancreatic Cancer"],"enrollment":24,"completionDate":"2028-12"},{"nctId":"NCT07013305","phase":"","title":"Pre- and Post-Treatment Investigation of B12 and Folic Acid (Folate) Levels in Patients Receiving Antiepileptic (Anticonvulsant) Treatment for Fibromyalgia: Retrospective Study","status":"COMPLETED","sponsor":"Gaziosmanpasa Research and Education Hospital","startDate":"2025-06-11","conditions":["Fibromyalgia (FM)","Vitamin B 12 Deficiency","Folic Acid Deficiency"],"enrollment":104,"completionDate":"2025-07-01"},{"nctId":"NCT07344974","phase":"PHASE4","title":"Hand and Foot Bath for Taxane-Induced Peripheral Neurotoxicity","status":"NOT_YET_RECRUITING","sponsor":"Peking University Cancer Hospital & Institute","startDate":"2026-02-01","conditions":["Breast Cancer"],"enrollment":78,"completionDate":"2027-02-01"},{"nctId":"NCT07344337","phase":"NA","title":"Evaluation of the Effect of a Dietary Supplement Based on EGCG, Vitamin B12, Hyaluronic Acid, and Folic Acid on the Maintenance of Physiological Balance and the Natural Defenses of the Male Genital System in Subjects Exposed to HPV Infection.","status":"NOT_YET_RECRUITING","sponsor":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","startDate":"2026-03","conditions":["HPV Infection","Infertilities"],"enrollment":96,"completionDate":"2028-03"},{"nctId":"NCT07341217","phase":"NA","title":"Chemo Brain Prehab Project","status":"NOT_YET_RECRUITING","sponsor":"Dr. Chris Gaffney","startDate":"2026-01-30","conditions":["Colorectal Cancer","Older Adults (60 - 85 Years Old)","Physically Inactive","Chemotherapy"],"enrollment":86,"completionDate":"2027-09-16"},{"nctId":"NCT07271316","phase":"PHASE2","title":"Alii Supplement Study","status":"RECRUITING","sponsor":"Texas Christian University","startDate":"2026-01-12","conditions":["Nutrient Deficiency","Happiness","Digestive Health","Vulnerability to Disease","Mood Swings","Energy"],"enrollment":68,"completionDate":"2026-04-29"},{"nctId":"NCT07341789","phase":"NA","title":"Effects of Vitamin B12 and Natural Orange Extract, and Their Combination on Physical and Mental Performance","status":"ENROLLING_BY_INVITATION","sponsor":"Francisco Javier Martínez Noguera","startDate":"2025-12-01","conditions":["Vitamin b12","Supplementation During Endurance Performance","Flavonoids","Mental Fatigue","Biomarker Feedback"],"enrollment":20,"completionDate":"2026-06"},{"nctId":"NCT07332429","phase":"NA","title":"Efficacy and Safety of Alcovit in Reducing Blood Alcohol Concentration","status":"NOT_YET_RECRUITING","sponsor":"Galzu Institute of Research, Teaching, Science and Applied Technology","startDate":"2026-05-30","conditions":["Alcohol Drinking","Blood Alcohol Content","Hangover"],"enrollment":228,"completionDate":"2027-05-30"},{"nctId":"NCT07320183","phase":"NA","title":"Effect of a Dietary Supplement Containing EGCG, Folic Acid, Vitamin B12 and Hyaluronic Acid in Supporting Male Genital Balance in Subjects Exposed to HPV Risk","status":"NOT_YET_RECRUITING","sponsor":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","startDate":"2026-03-01","conditions":["HPV - Anogenital Human Papilloma Virus Infection","Infertilities"],"enrollment":96,"completionDate":"2028-03"},{"nctId":"NCT05175248","phase":"NA","title":"Nutritional Intervention for Endometriosis","status":"RECRUITING","sponsor":"Physicians Committee for Responsible Medicine","startDate":"2022-03-02","conditions":["Endometriosis"],"enrollment":120,"completionDate":"2026-12"},{"nctId":"NCT07312435","phase":"NA","title":"B-vitamins and Omega-3 Fatty Acids and Biomarkers of Brain Atrophy.","status":"RECRUITING","sponsor":"University of Oslo","startDate":"2025-09-01","conditions":["Dementia","Cognitive Function"],"enrollment":96,"completionDate":"2028-06-01"},{"nctId":"NCT07312123","phase":"NA","title":"A Study to See Whether Taking a Mix of Vitamins Can Help Adults Recover Better After Surgery for Carpal Tunnel Syndrome","status":"RECRUITING","sponsor":"Hospital Universiti Sains Malaysia","startDate":"2025-12-08","conditions":["Carpal Tunnel Syndrome"],"enrollment":84,"completionDate":"2027-01-31"},{"nctId":"NCT07309952","phase":"PHASE2","title":"Neoadjuvant SBRT Followed by Sintilimab Plus Chemotherapy for N3-Positive NSCLC","status":"NOT_YET_RECRUITING","sponsor":"Yang Hong","startDate":"2025-12-31","conditions":["Locally Advanced Non-Small Cell Lung Cancer","Stage IIIb Non-small Cell Lung Cancer","Stage IIIC Non-Small Cell Lung Cancer"],"enrollment":28,"completionDate":"2032-10-31"},{"nctId":"NCT07304453","phase":"PHASE2","title":"Nucleo CMP and Neurorubine Versus Carbamazepine for Classical Trigeminal Neuralgia","status":"COMPLETED","sponsor":"Karbala University","startDate":"2024-01-07","conditions":["Trigeminal Neuralgia","Neuropathic Pain"],"enrollment":38,"completionDate":"2024-09-30"},{"nctId":"NCT07022938","phase":"PHASE4","title":"Nutritional Supplement for Treating Chemotherapy Induced Neuropathy","status":"COMPLETED","sponsor":"Aristotle University Of Thessaloniki","startDate":"2021-11-01","conditions":["Cancer","Neuropathy","Chemotherapy Induced Pain Neuropathy","Chemotherapy-Induced Peripheral Neuropathy"],"enrollment":71,"completionDate":"2025-12-15"},{"nctId":"NCT05827926","phase":"PHASE1,PHASE2","title":"A Study of mRNA-based Influenza and SARS-CoV-2 (COVID-19) Multi-component Vaccines in Healthy Adults","status":"COMPLETED","sponsor":"ModernaTX, Inc.","startDate":"2023-04-14","conditions":["SARS-CoV-2","Influenza"],"enrollment":1758,"completionDate":"2024-12-03"},{"nctId":"NCT07296354","phase":"PHASE4","title":"Evaluation of an ATP-Containing Parenteral Vitamin B Complex in Patients With Symptomatic Diabetic Polyneuropathy","status":"NOT_YET_RECRUITING","sponsor":"Egyptian International Pharmaceutical Industries Co","startDate":"2026-01-10","conditions":["Neuropathic Pain"],"enrollment":200,"completionDate":"2029-01-10"},{"nctId":"NCT07205354","phase":"","title":"Design of a Food Preference Assessment Tool for Older Patients in Geriatrics units_DYSPHAGING-PREFERENCES","status":"RECRUITING","sponsor":"Hospices Civils de Lyon","startDate":"2025-10-10","conditions":["Hospitalisation in Geriatrics","Swallowing Disorder","Eating Habits"],"enrollment":209,"completionDate":"2027-02-10"},{"nctId":"NCT07284095","phase":"NA","title":"Nutritional Intervention With Tenebrio Molitor Powder in Children With Chronic Malnutrition in the Democratic Republic of the Congo","status":"NOT_YET_RECRUITING","sponsor":"Clinica Universidad de Navarra, Universidad de Navarra","startDate":"2026-02-01","conditions":["Chronic Malnutrition","Stunting of Growth"],"enrollment":40,"completionDate":"2026-08"},{"nctId":"NCT06983223","phase":"NA","title":"Oral Sucrosomial® Vitamin B12 in the Management of B12 Deficiency Among Metformin-Treated Type 2 Diabetes Patients","status":"COMPLETED","sponsor":"Liaquat University of Medical & Health Sciences","startDate":"2025-08-15","conditions":["Vitamin B 12 Deficiency","Type 2 Diabetes Mellitus (T2DM)"],"enrollment":50,"completionDate":"2025-12-03"},{"nctId":"NCT06581900","phase":"","title":"Study of Vitamin B12 Metabolism in Children With Sickle Cell Disease Exposed to MEOPA","status":"RECRUITING","sponsor":"CHU de Reims","startDate":"2024-11-27","conditions":["Sickle Cells Patients"],"enrollment":29,"completionDate":"2026-12"},{"nctId":"NCT03887169","phase":"PHASE1,PHASE2","title":"Administration of Methionine in Patients With Pulmonary Alveolar Proteinosis by Mutation of the MARS Gene.","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2019-09-16","conditions":["Pulmonary Alveolar Proteinosis","Mutation Ala393Thr of the MARS Gene","mutationSer567Leu of the MARS Gene"],"enrollment":3,"completionDate":"2020-06-01"},{"nctId":"NCT06285357","phase":"NA","title":"The Effect of the Association EGCG, Folic Acid and Vitamin B12 in Preventing the Persistence of HPV Infection.","status":"RECRUITING","sponsor":"Lo.Li.Pharma s.r.l","startDate":"2024-02-19","conditions":["HPV Infection"],"enrollment":100,"completionDate":"2026-08"},{"nctId":"NCT04760353","phase":"NA","title":"The Effect of a Probiotic Mixture in Obese Patients With Irritable Bowel Syndrome","status":"COMPLETED","sponsor":"University Hospital Rijeka","startDate":"2021-11-10","conditions":["IBS - Irritable Bowel Syndrome","Obesity"],"enrollment":80,"completionDate":"2025-10-17"},{"nctId":"NCT07221266","phase":"NA","title":"Changes in Movement, Fitness, and Quality of Life in People With Parkinson's Disease After Different Exercise Programs","status":"NOT_YET_RECRUITING","sponsor":"University of Texas, El Paso","startDate":"2025-11-03","conditions":["Parkinson Disease (PD)"],"enrollment":45,"completionDate":"2027-06-30"},{"nctId":"NCT07215676","phase":"NA","title":"A Trial of a Multi-Component Nutritional Supplement in Hydrogen-Dominant Small Intestinal Bacterial Overgrowth","status":"NOT_YET_RECRUITING","sponsor":"National University of Natural Medicine","startDate":"2025-10","conditions":["Small Intestinal Bacterial Overgrowth Syndrome (SIBO)","Small Intestinal Bacterial Overgrowth"],"enrollment":10,"completionDate":"2026-09"},{"nctId":"NCT07200739","phase":"","title":"Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients","status":"ENROLLING_BY_INVITATION","sponsor":"Zealand University Hospital","startDate":"2025-10-01","conditions":["Dementia (Diagnosis)","Alzheimer Dementia (AD)","Vascular Dementia (VaD)","Lewy Body Dementia (LBD)","Frontotemporal Dementia (FTD)","Mild Cognitive Impairment (MCI)","Depression - Major Depressive Disorder"],"enrollment":340,"completionDate":"2028-06"},{"nctId":"NCT06241638","phase":"NA","title":"Improving HbA1c Levels by Methylcobalamin Vitamin in Diabetic Volunteers","status":"COMPLETED","sponsor":"Al-Balqa Applied University","startDate":"2022-07-01","conditions":["Diabetes Mellitus"],"enrollment":80,"completionDate":"2023-06-30"},{"nctId":"NCT06081114","phase":"NA","title":"Micronutrient Dose Response Study in Bangladesh","status":"ACTIVE_NOT_RECRUITING","sponsor":"Johns Hopkins Bloomberg School of Public Health","startDate":"2023-10-22","conditions":["Micronutrient Status"],"enrollment":643,"completionDate":"2026-09-30"},{"nctId":"NCT07013318","phase":"","title":"Pre- and Post-Treatment Investigation of B12 and Folic Acid (Folate) Levels in Patients Receiving Antiepileptic (Anticonvulsant) Treatment for Neuropathic Pain","status":"COMPLETED","sponsor":"Gaziosmanpasa Research and Education Hospital","startDate":"2025-06-15","conditions":["Neuropathic Pain","Vitamin B 12 Deficiency"],"enrollment":96,"completionDate":"2025-07-05"},{"nctId":"NCT06813274","phase":"PHASE2","title":"Multicenter RCT of Eye-Brain Imaging in Diabetes Neurovascular Coupling","status":"NOT_YET_RECRUITING","sponsor":"Hejiang Ye","startDate":"2026-01-01","conditions":["Diabetes Mellitus","Diabetic Retinopathy","Cognitive Impairment","Neurovascular Coupling"],"enrollment":160,"completionDate":"2026-12-01"},{"nctId":"NCT05067998","phase":"","title":"The Benefits of Natural Medicine, Vitamin IV Therapy and Supplements: Maintaining Good Health Through Nature","status":"RECRUITING","sponsor":"Faith A. Richardson","startDate":"2025-12-21","conditions":["Anxiety Disorders and Symptoms","Fibromyalgia","Arthritis","Chronic Pain","Hypertension,Essential"],"enrollment":25,"completionDate":"2026-09-17"},{"nctId":"NCT07173881","phase":"NA","title":"Effect of a Dairy Product for Pregnant and Lactating Women on the Composition of Human Milk","status":"RECRUITING","sponsor":"Instituto de Desarrollo e Investigaciones Pediátricas Prof. Dr. Fernando E. Viteri","startDate":"2025-08-01","conditions":["Pregnancy"],"enrollment":20,"completionDate":"2026-01-30"},{"nctId":"NCT07163962","phase":"","title":"THE B-BABIES STUDY: An Observational Study of Group B Vitamins in Preterm Infants","status":"NOT_YET_RECRUITING","sponsor":"Norfolk and Norwich University Hospitals NHS Foundation Trust","startDate":"2025-09-01","conditions":["Vitamin B-12 Deficiency"],"enrollment":40,"completionDate":"2026-09-30"},{"nctId":"NCT06911073","phase":"NA","title":"A Study to Evaluate a Postbiotic in Supporting Weight Loss and Metabolic Health","status":"RECRUITING","sponsor":"ResBiotic Nutrition, Inc.","startDate":"2025-05-02","conditions":["Obesity and Overweight"],"enrollment":80,"completionDate":"2025-12"},{"nctId":"NCT07163364","phase":"PHASE3","title":"A Study to Evaluate the Effects and Safety of Hydroxocobalamin in Participants With Combined Methylmalonic Academia (cblC Type)","status":"NOT_YET_RECRUITING","sponsor":"CSPC ZhongQi Pharmaceutical Technology Co., Ltd.","startDate":"2025-08-31","conditions":["Methylmalonic Acidemia (MMA)"],"enrollment":20,"completionDate":"2027-04-28"},{"nctId":"NCT07157137","phase":"","title":"Assessment of the Adherence to a Gluten-free Diet and Nutritional Status of Paediatric Patients With Coeliac Disease","status":"NOT_YET_RECRUITING","sponsor":"Medical University of Warsaw","startDate":"2026-01","conditions":["Celiac Disease in Children","Gluten-free Diet"],"enrollment":140,"completionDate":"2027-08"},{"nctId":"NCT06948929","phase":"NA","title":"Synbiotic Formula (SCV09) in Alzheimer's Disease Patients","status":"RECRUITING","sponsor":"Chinese University of Hong Kong","startDate":"2025-05-15","conditions":["Alzheimer Disease"],"enrollment":30,"completionDate":"2026-12-15"},{"nctId":"NCT02378246","phase":"NA","title":"Swedish Iodine in Pregnancy and Development in Children (SWIDDICH) Study","status":"ACTIVE_NOT_RECRUITING","sponsor":"Göteborg University","startDate":"2012-11","conditions":["Thyroid Gland; Node","Pregnancy","Cognitive Developmental Delay"],"enrollment":1337,"completionDate":"2032-06"},{"nctId":"NCT06641349","phase":"","title":"Effect of Maternal Supplementation From Preconception to Lactation on Child Growth and Development","status":"COMPLETED","sponsor":"University of Toronto","startDate":"2025-01-13","conditions":["Malnutrition","Growth &Amp; Development"],"enrollment":150,"completionDate":"2025-06-04"},{"nctId":"NCT06347315","phase":"NA","title":"Evaluation of the Effects of a Nutritional Intervention of Ketogenic Medium-chain Triglycerides and B-vitamins on Cognitive Functioning in Older Adults With Mild Cognitive Impairment (COGNIKET-MCI)","status":"RECRUITING","sponsor":"Société des Produits Nestlé (SPN)","startDate":"2024-05-24","conditions":["Mild Cognitive Impairment"],"enrollment":380,"completionDate":"2027-12-15"},{"nctId":"NCT07119788","phase":"NA","title":"Investigating the Effects of a Haskap Berry Supplement on Cognitive Health","status":"RECRUITING","sponsor":"University of Reading","startDate":"2025-06-19","conditions":["Cognition"],"enrollment":90,"completionDate":"2026-04"},{"nctId":"NCT07118657","phase":"NA","title":"Host-Diet-Gut Interaction Post Vegan Diet in Pediatric Autoimmune Hepatitis.","status":"NOT_YET_RECRUITING","sponsor":"Institute of Liver and Biliary Sciences, India","startDate":"2025-09-10","conditions":["Autoimmune Hepatitis"],"enrollment":40,"completionDate":"2028-04-30"},{"nctId":"NCT07111767","phase":"NA","title":"Effectiveness of a Modified Cost-Effective Dietary Plan in Promoting Weight Loss and Preservation of Lean Body Mass in Patients After Bariatric Surgery","status":"NOT_YET_RECRUITING","sponsor":"Khyber Teaching Hospital","startDate":"2025-10","conditions":["Obesity","Bariatric Surgery","Nutritional Status","Body Composition"],"enrollment":122,"completionDate":"2026-06"},{"nctId":"NCT05682261","phase":"NA","title":"The Effect of Multiple Micronutrient Supplements in Reducing Anemia in Women of Reproductive Age","status":"COMPLETED","sponsor":"Ethiopian Public Health Institute","startDate":"2023-03-23","conditions":["Anemia"],"enrollment":265,"completionDate":"2023-10-17"},{"nctId":"NCT07100795","phase":"","title":"Vitamin B12, Folic Acid and Vitamin D Status in Women of Reproductive Age","status":"RECRUITING","sponsor":"University of Mostar","startDate":"2024-12-23","conditions":["Vitamin D, Vitamin B 12 and Folic Acid Concentrations","Micronutrient Status in Women of Reproductive Age","Vitamin Status Assessment"],"enrollment":360,"completionDate":"2025-12-01"},{"nctId":"NCT04547816","phase":"PHASE3","title":"Efficacy of Conservative Treatment of Functional Defecatory Disorders in Females With Pelvic Organ Prolapse","status":"RECRUITING","sponsor":"Federal State Budgetary Scientific Institution \"Federal Research Centre of Nutrition, Biotechnology","startDate":"2020-07-01","conditions":["Pelvic Floor Prolapse","Functional Constipation","Rectocele"],"enrollment":100,"completionDate":"2026-05-31"},{"nctId":"NCT07099586","phase":"","title":"Vitamin B12, Folic Acid, and Vitamin D Status in Women of Reproductive Age","status":"RECRUITING","sponsor":"University of Mostar","startDate":"2024-12-20","conditions":["Vitamin d, Vitamin B 12 and Folic Acid Concentrations","Micronutrient Status in Women of Reproductive Age","Vitamin Status Assessment"],"enrollment":360,"completionDate":"2025-12-01"},{"nctId":"NCT05714917","phase":"","title":"Neurological Recovery Following NOS-SACD","status":"RECRUITING","sponsor":"Nottingham University Hospitals NHS Trust","startDate":"2024-08-19","conditions":["Nitrous Oxide Abuse","Subacute Combined Cord Degeneration","Neurologic Symptoms","Paresthesia","B12 Deficiency Vitamin"],"enrollment":100,"completionDate":"2026-08-19"},{"nctId":"NCT07048860","phase":"NA","title":"ICOPE INTENSE-K Pilot Study","status":"RECRUITING","sponsor":"University Hospital, Toulouse","startDate":"2025-07-09","conditions":["Ageing"],"enrollment":40,"completionDate":"2025-12-31"},{"nctId":"NCT06904612","phase":"","title":"Using Iodized Salt to Improve Serum Folate, B12 and Iron Levels","status":"COMPLETED","sponsor":"Hydrocephalus and Neuroscience Institute","startDate":"2022-06-01","conditions":["Neural Tube Defects","Folic Acid Deficiency","Spina Bifida","Anencephaly-Spina Bifida","B12 Deficiency Vitamin","Anemia","Iron Deficiency Anaemia Due to Dietary Causes"],"enrollment":200,"completionDate":"2022-11-30"},{"nctId":"NCT06319534","phase":"NA","title":"Stellate Ganglion Block in Bulbar Palsy","status":"COMPLETED","sponsor":"Copka Sonpashan","startDate":"2024-03-23","conditions":["Bulbar Palsy"],"enrollment":124,"completionDate":"2025-07-05"},{"nctId":"NCT06990854","phase":"NA","title":"Electroacupuncture for PHN: Efficacy and Biomarker Evaluation in a Multicenter, Randomized, Sham-Controlled Trial Protocol","status":"NOT_YET_RECRUITING","sponsor":"Dexiong Han","startDate":"2025-07-01","conditions":["Postherpetic Neuralgia ( PHN )"],"enrollment":207,"completionDate":"2026-12"},{"nctId":"NCT07036497","phase":"","title":"THE IMPACT OF VITAMIN B12 TREATMENT ON EJACULATORY FUNCTIONS IN MEN: SYMPTOMATIC RELIEF AND IMPROVED OUTCOMES","status":"COMPLETED","sponsor":"OZGUR EKICI","startDate":"2024-10-01","conditions":["Premature Ejaculation"],"enrollment":54,"completionDate":"2025-05-01"},{"nctId":"NCT07029698","phase":"PHASE4","title":"A Study to See if a Combination of Vitamins That is Injected Into a Muscle is as Good and Safe as a Vitamin That is Taken by Mouth","status":"RECRUITING","sponsor":"Medice Arzneimittel Pütter GmbH & Co KG","startDate":"2025-04-16","conditions":["Vitamin B12 Deficiency"],"enrollment":46,"completionDate":"2026-12"},{"nctId":"NCT06420375","phase":"PHASE2","title":"Treatment of UC With Novel Therapeutics","status":"RECRUITING","sponsor":"Brigham and Women's Hospital","startDate":"2025-05-27","conditions":["Ulcerative Colitis Mild","Ulcerative Colitis"],"enrollment":20,"completionDate":"2027-07-31"},{"nctId":"NCT06264570","phase":"NA","title":"Evaluation of a Genetically Determined Personalized Approach in Prescribing Biologically Active Substances in Patients With Elevated Blood Homocysteine Levels.","status":"RECRUITING","sponsor":"S.LAB (SOLOWAYS)","startDate":"2023-10-23","conditions":["Hyperhomocysteinemia"],"enrollment":111,"completionDate":"2026-10-30"},{"nctId":"NCT05324475","phase":"NA","title":"Maintaining Immune and Mitochondrial Functions in Old Adults With SAfe Nutrition.","status":"RECRUITING","sponsor":"Patrizia D'Amelio","startDate":"2025-04-01","conditions":["Malnutrition","Sarcopenia"],"enrollment":240,"completionDate":"2028-03-30"},{"nctId":"NCT05366933","phase":"PHASE1","title":"B-Complex: A Nutraceutical SANS Countermeasure","status":"RECRUITING","sponsor":"National Aeronautics and Space Administration (NASA)","startDate":"2022-08-01","conditions":["Optic Disc Edema","Endothelial Dysfunction"],"enrollment":16,"completionDate":"2032-09-30"},{"nctId":"NCT05096663","phase":"PHASE2,PHASE3","title":"Testing the Use of Combination Immunotherapy Treatment (N-803 [ALT-803] Plus Pembrolizumab) Against the Usual Treatment for Advanced Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial)","status":"ACTIVE_NOT_RECRUITING","sponsor":"SWOG Cancer Research Network","startDate":"2022-03-15","conditions":["Advanced Lung Non-Small Cell Carcinoma","Recurrent Lung Non-Small Cell Carcinoma","Stage III Lung Cancer AJCC v8","Stage IIIA Lung Cancer AJCC v8","Stage IIIB Lung Cancer AJCC v8","Stage IIIC Lung Cancer AJCC v8","Stage IV Lung Cancer AJCC v8","Stage IVA Lung Cancer AJCC v8","Stage IVB Lung Cancer AJCC v8"],"enrollment":82,"completionDate":"2027-12-01"},{"nctId":"NCT06968884","phase":"NA","title":"Application of a Comprehensive Protocol Aimed at Reducing the Risk of Complications After Surgery for Sarcoma. Interventions Before, During and After Surgery for Known and Presumed Risk Factors Compared to Standard of Care in a Total of 300 Patients.","status":"ENROLLING_BY_INVITATION","sponsor":"Region Stockholm","startDate":"2024-09-24","conditions":["Surgical Complications","Sarcoma"],"enrollment":300,"completionDate":"2028-12"},{"nctId":"NCT06966856","phase":"PHASE3","title":"This Randomized, Clinical Trial Evaluates the Efficacy of Oral Versus Sublingual Vitamin B12 Supplementation in Correcting Early-onset Vitamin B12 Deficiency in Adult Patients Using Proton Pump Inhibitors (PPIs). The Primary Outcome is the Change in Serum Vitamin B12 Levels Over a 6-week","status":"NOT_YET_RECRUITING","sponsor":"Tanta University","startDate":"2026-12-30","conditions":["Hypovitaminosis b 12"],"enrollment":23,"completionDate":"2029-12-30"},{"nctId":"NCT05289908","phase":"PHASE1,PHASE2","title":"Intrathecal Pemetrexed for Leptomeningeal Metastasis","status":"COMPLETED","sponsor":"The First Hospital of Jilin University","startDate":"2022-02-21","conditions":["Leptomeningeal Metastases"],"enrollment":34,"completionDate":"2024-03-31"},{"nctId":"NCT06885827","phase":"NA","title":"Vitamin Mix (B6, B9, B12, And Choline) For Glaucoma Patients","status":"RECRUITING","sponsor":"Karolinska Institutet","startDate":"2025-03-31","conditions":["Open-angle Glaucoma","Pseudoexfoliation Glaucoma"],"enrollment":80,"completionDate":"2027-03-31"},{"nctId":"NCT06940557","phase":"PHASE2,PHASE3","title":"Efficacy And Tolerability Of Alpha Lipoic Acid And Vitamin B Preparation In Carpal Tunnel Syndrome","status":"COMPLETED","sponsor":"Universiti Putra Malaysia","startDate":"2023-12-01","conditions":["Carpal Tunnel Syndrome (CTS)"],"enrollment":70,"completionDate":"2024-09-30"},{"nctId":"NCT04343170","phase":"NA","title":"Effect of Ultra-short-term Treatment of Patients With Iron Deficiency or Anemia Undergoing Adolescent Scoliosis Correction","status":"COMPLETED","sponsor":"Tanta University","startDate":"2023-09-01","conditions":["Ultra-short-term","Iron Deficiency Anemia","Scoliosis Idiopathic"],"enrollment":44,"completionDate":"2024-10-01"},{"nctId":"NCT05315843","phase":"","title":"Cobalamin Supply and Metabolism in Healthy Children From Birth to the Age of 12 Months and in Their Mothers (Cbl_Neo)","status":"COMPLETED","sponsor":"University Children's Hospital, Zurich","startDate":"2022-11-07","conditions":["Vitamin B 12 Deficiency"],"enrollment":160,"completionDate":"2024-12-31"},{"nctId":"NCT06921018","phase":"NA","title":"Bioavailability of Micronutrients With a Special Focus on Vitamin K Dependent on Consumed Diet","status":"NOT_YET_RECRUITING","sponsor":"University of Copenhagen","startDate":"2025-04-01","conditions":["Micronutrient Status"],"enrollment":20,"completionDate":"2031-06-30"},{"nctId":"NCT06516094","phase":"PHASE3","title":"Efficacy and Safety in the Combination of Celecoxib / Pregabalin / Vitamin B for Low Back Chronic Pain","status":"COMPLETED","sponsor":"Laboratorios Silanes S.A. de C.V.","startDate":"2024-04-11","conditions":["Chronic Low-back Pain"],"enrollment":192,"completionDate":"2025-01-07"},{"nctId":"NCT03337360","phase":"NA","title":"The Impact of a Nutritional Supplement (Impryl®) on Male Fertility","status":"ACTIVE_NOT_RECRUITING","sponsor":"Radboud University Medical Center","startDate":"2018-04-23","conditions":["Male Subfertility"],"enrollment":1200,"completionDate":"2026-04-30"},{"nctId":"NCT04786964","phase":"PHASE3","title":"Study of Pemetrexed+Platinum Chemotherapy With or Without Cosibelimab in First Line Metastatic Non-squamous NSCLC","status":"TERMINATED","sponsor":"Checkpoint Therapeutics, Inc.","startDate":"2021-12-08","conditions":["Metastatic Non-squamous Non Small Cell Lung Cancer"],"enrollment":25,"completionDate":"2023-12-30"},{"nctId":"NCT05638633","phase":"PHASE3","title":"Prednisolone and Vitamin B1/6/12 in Patients With Post-Covid-Syndrome","status":"COMPLETED","sponsor":"Wuerzburg University Hospital","startDate":"2022-11-11","conditions":["Post-COVID-19 Syndrome"],"enrollment":321,"completionDate":"2025-01-30"},{"nctId":"NCT01147289","phase":"PHASE3","title":"Efficacy and Safety of Injectable Association of Dexamethasone, Dipyrone and Hydrocobalamin in Lumbar Sciatic Pain","status":"COMPLETED","sponsor":"Eurofarma Laboratorios S.A.","startDate":"2011-02","conditions":["Lumbar Sciatic Pain"],"enrollment":280,"completionDate":"2012-04"},{"nctId":"NCT06163443","phase":"NA","title":"Evaluating the Impact of B Vitamin Supplementation (Soloways™) on Homocysteine and LDL-C Levels in Patients With MTHFR, MTR, and MTRR Polymorphisms.","status":"COMPLETED","sponsor":"S.LAB (SOLOWAYS)","startDate":"2022-03-02","conditions":["Hyperhomocysteinemia","Hyperlipoproteinemias"],"enrollment":54,"completionDate":"2023-05-01"},{"nctId":"NCT03548311","phase":"PHASE3","title":"Clinical Trial of Ultra-high Dose Methylcobalamin for ALS","status":"COMPLETED","sponsor":"Eisai Co., Ltd.","startDate":"2017-11-01","conditions":["Amyotrophic Lateral Sclerosis"],"enrollment":130,"completionDate":"2025-02-18"},{"nctId":"NCT06718426","phase":"NA","title":"Evaluation of Fertitonex Effects on Semen Parameters in Clinical Varicocele Patient.","status":"RECRUITING","sponsor":"Menoufia University","startDate":"2024-12-01","conditions":["Varicocele"],"enrollment":110,"completionDate":"2026-02-01"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{"route":"Oral","formulation":"Capsule, Tablet","formulations":[{"form":"CAPSULE","route":"ORAL","productName":"Biopar delta-FORTE"},{"form":"TABLET, CHEWABLE","route":"ORAL","productName":"Select OB"},{"form":"TABLET, COATED","route":"ORAL","productName":"Dialyvite"},{"form":"TABLET, COATED","route":"ORAL","productName":"Dialyvite 3000"},{"form":"TABLET, COATED","route":"ORAL","productName":"Dialyvite 5000"},{"form":"TABLET, COATED","route":"ORAL","productName":"Dialyvite Supreme D"},{"form":"TABLET, COATED","route":"ORAL","productName":"Dialyvite with Zinc"},{"form":"TABLET, COATED","route":"ORAL","productName":"NephPlex Rx"},{"form":"TABLET, COATED","route":"ORAL","productName":"Nephron FA"},{"form":"TABLET, COATED","route":"ORAL","productName":"Vital-D Rx"}]},"crossReferences":{"NUI":"N0000179300","MMSL":"213062","NDDF":"001043","UNII":"8406EY2OQA","VUID":"4017907","CHEBI":"CHEBI:30411","VANDF":"4017441","RXNORM":"11248","UMLSCUI":"C0042845","chemblId":"CHEMBL4297272","ChEMBL_ID":"CHEMBL4297272","DRUGBANK_ID":"DB14098","PDB_CHEM_ID":" B12","PUBCHEM_CID":"5311498","SNOMEDCT_US":"30010009"},"formularyStatus":[],"_enricherVersion":"v2","_offLabelChecked":true,"developmentCodes":[],"ownershipHistory":[],"publicationCount":5723,"therapeuticAreas":["Metabolic"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Mar 27","pmid":"41905540","title":"Vitamin B12 Attenuates Post-Ischemic Brain Fibrotic Remodeling and Suppresses MAPK1 Signaling in Male Rats.","journal":"Brain research bulletin"},{"date":"2026 Mar 5","pmid":"41891996","title":"Thiamine and Micronutrient Deficiencies in Hospitalized Veterans Without Alcohol Use Disorder.","journal":"Diseases (Basel, Switzerland)"},{"date":"2026","pmid":"41890422","title":"Encephalitis-like presentation of methylmalonic acidemia with homocystinuria in a postpartum woman: a case report.","journal":"Frontiers in psychiatry"},{"date":"2026 Mar 26","pmid":"41885699","title":"Impact of blood donation on serum cobalamin and folic acid concentrations in dogs.","journal":"Australian veterinary journal"},{"date":"2026 Mar 19","pmid":"41851124","title":"Seasonal frost improves probiotic and nutrient availability in fermented vegetables.","journal":"NPJ science of food"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"COBALAMIN","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":""},{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"BR","regulator":"ANVISA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"MX","regulator":"COFEPRIS","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AR","regulator":"ANMAT","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"TR","regulator":"TITCK","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"IN","regulator":"CDSCO","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"TH","regulator":"FDA-TH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"MY","regulator":"NPRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"PH","regulator":"FDA-PH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"CO","regulator":"INVIMA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"ZA","regulator":"SAHPRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"TW","regulator":"TFDA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"HK","regulator":"DH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"IL","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"SG","regulator":"HSA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AE","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"KR","regulator":"MFDS","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AU","regulator":"TGA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"GB","regulator":"MHRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T00:30:25.592031+00:00","fieldsConflicting":1,"overallConfidence":0.8},"verificationStatus":"verified","dataCompleteness":{"mechanism":false,"indications":true,"safety":true,"trials":true,"score":3}}