{"id":"coagulation-factor-viii","safety":{"commonSideEffects":[{"rate":null,"effect":"Inhibitor development (alloimmunization)"},{"rate":null,"effect":"Infusion reactions"},{"rate":null,"effect":"Thrombosis"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Factor VIII is a critical cofactor in the intrinsic coagulation cascade that works with Factor IX to activate Factor X, ultimately leading to thrombin generation and fibrin clot formation. In hemophilia A, Factor VIII is either absent or non-functional, causing severe bleeding. Replacement therapy restores this enzymatic activity and corrects the coagulation defect.","oneSentence":"Coagulation Factor VIII replaces deficient or dysfunctional clotting factor VIII to restore the intrinsic coagulation pathway and enable normal blood clot formation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:43:38.710Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hemophilia A (congenital Factor VIII deficiency)"},{"name":"Acquired hemophilia A"}]},"trialDetails":[{"nctId":"NCT07285460","phase":"PHASE3","title":"A Study to Investigate the Efficacy and Safety of Fitusiran Prophylaxis in Male Participants Aged 1 to Less Than 12 Years With Hemophilia A or B","status":"RECRUITING","sponsor":"Sanofi","startDate":"2025-12-18","conditions":"Hemophilia","enrollment":85},{"nctId":"NCT06940830","phase":"PHASE4","title":"Long-term Study Evaluating Joint Health in People With Haemophilia A Receiving Real-world Prophylactic Treatment With 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