{"id":"co-latanoprost","safety":{"commonSideEffects":[{"rate":"25-50","effect":"Conjunctival hyperemia"},{"rate":"10-25","effect":"Iris pigmentation increase"},{"rate":"10-25","effect":"Eyelash growth (hypertrichosis)"},{"rate":"5-15","effect":"Eye irritation/discomfort"},{"rate":"5-10","effect":"Periocular skin pigmentation"}]},"_chembl":{"chemblId":"CHEMBL1051","moleculeType":"Small molecule","molecularWeight":"432.60"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Latanoprost is a selective prostaglandin F (FP) receptor agonist that increases uveoscleral outflow of aqueous humor, thereby lowering intraocular pressure. The combination formulation enhances efficacy through complementary mechanisms to achieve greater IOP reduction than monotherapy alone.","oneSentence":"Co-Latanoprost is a fixed-dose combination of latanoprost (a prostaglandin F analog) and another agent that works synergistically to reduce intraocular pressure in glaucoma.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:19:15.176Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Open-angle glaucoma"},{"name":"Ocular hypertension"}]},"trialDetails":[{"nctId":"NCT02792803","phase":"PHASE4","title":"A Comparison of Xalatan (Latanoprost) to Apo-latanoprost and Co-latanoprost in the Treatment of Glaucoma","status":"UNKNOWN","sponsor":"Dr. David Yan","startDate":"2015-09","conditions":"POAG, Primary Open Angle Glaucoma, Ocular Hypertension","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["02254786"],"phase":"marketed","status":"active","brandName":"Co-Latanoprost","genericName":"Co-Latanoprost","companyName":"Dr. David Yan","companyId":"dr-david-yan","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Co-Latanoprost is a fixed-dose combination of latanoprost (a prostaglandin F analog) and another agent that works synergistically to reduce intraocular pressure in glaucoma. Used for Open-angle glaucoma, Ocular hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}