{"id":"cloxazolam","rwe":[],"tags":[{"label":"cloxazolam","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Aldo-keto reductase family 1 member C3","category":"target"},{"label":"AKR1C3","category":"gene"},{"label":"N05BA22","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{"safetySignals":[{"llr":40.884,"date":"","count":15,"signal":"Drug dependence","source":"DrugCentral FAERS","actionTaken":"Reported 15 times (LLR=41)"},{"llr":36.526,"date":"","count":8,"signal":"Panic disorder","source":"DrugCentral FAERS","actionTaken":"Reported 8 times (LLR=37)"}],"commonSideEffects":[{"effect":"Drug dependence","drugRate":"LLR 41","severity":"common"},{"effect":"Panic disorder","drugRate":"LLR 37","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"cloxazolazepam","offLabel":[],"synonyms":["cloxazolam","cloxazolazepam"],"timeline":[],"approvals":[],"brandName":"Cloxazolazepam","ecosystem":[],"mechanism":{"target":"Aldo-keto reductase family 1 member C3","targets":[{"gene":"AKR1C3","source":"DrugCentral","target":"Aldo-keto reductase family 1 member C3","protein":"Aldo-keto reductase family 1 member C3"}],"modality":"Small Molecule","drugClass":"cloxazolam","explanation":"Think of it like a key that unlocks a door. In this case, the key is Cloxazolazepam, and the door is the enzyme Aldo-keto reductase family 1 member C3. By inhibiting this enzyme, Cloxazolazepam can affect the way the body processes certain chemicals, leading to its therapeutic effects.","oneSentence":"Cloxazolazepam works by inhibiting the enzyme Aldo-keto reductase family 1 member C3.","technicalDetail":"Cloxazolazepam acts as a competitive inhibitor of Aldo-keto reductase family 1 member C3, a key enzyme involved in the reduction of various endogenous and exogenous substrates, thereby modulating the activity of this enzyme and potentially influencing the levels of its substrates in the body."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/721","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CLOXAZOLAM","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:14:43.323156","biosimilars":[],"competitors":[{"drugName":"diazepam","drugSlug":"diazepam","fdaApproval":"1963-11-15","patentExpiry":"Oct 16, 2032","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"chlordiazepoxide","drugSlug":"chlordiazepoxide","fdaApproval":"1960-02-24","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"oxazepam","drugSlug":"oxazepam","fdaApproval":"1965-06-04","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"clorazepate","drugSlug":"clorazepate","fdaApproval":"1972-06-23","genericCount":19,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"lorazepam","drugSlug":"lorazepam","fdaApproval":"1977-09-30","patentExpiry":"Jan 8, 2034","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"clobazam","drugSlug":"clobazam","fdaApproval":"2011-10-21","patentExpiry":"Sep 5, 2039","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"prazepam","drugSlug":"prazepam","fdaApproval":"","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"alprazolam","drugSlug":"alprazolam","fdaApproval":"1981-10-16","genericCount":24,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"halazepam","drugSlug":"halazepam","fdaApproval":"1981-09-24","patentStatus":"Unknown","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"cloxazolam","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"diazepam","brandName":"diazepam","genericName":"diazepam","approvalYear":"1963","relationship":"same-class"},{"drugId":"chlordiazepoxide","brandName":"chlordiazepoxide","genericName":"chlordiazepoxide","approvalYear":"1960","relationship":"same-class"},{"drugId":"oxazepam","brandName":"oxazepam","genericName":"oxazepam","approvalYear":"1965","relationship":"same-class"},{"drugId":"clorazepate","brandName":"clorazepate","genericName":"clorazepate","approvalYear":"1972","relationship":"same-class"},{"drugId":"lorazepam","brandName":"lorazepam","genericName":"lorazepam","approvalYear":"1977","relationship":"same-class"},{"drugId":"clobazam","brandName":"clobazam","genericName":"clobazam","approvalYear":"2011","relationship":"same-class"},{"drugId":"prazepam","brandName":"prazepam","genericName":"prazepam","approvalYear":"","relationship":"same-class"},{"drugId":"alprazolam","brandName":"alprazolam","genericName":"alprazolam","approvalYear":"1981","relationship":"same-class"},{"drugId":"halazepam","brandName":"halazepam","genericName":"halazepam","approvalYear":"1981","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"006709","UNII":"GYL649Z0HY","CHEBI":"CHEBI:31426","INN_ID":"3400","RXNORM":"21311","UMLSCUI":"C0055964","ChEMBL_ID":"CHEMBL2107254","KEGG_DRUG":"D01268","DRUGBANK_ID":"DB01553","PUBCHEM_CID":"2816","SNOMEDCT_US":"16211000122103","MESH_SUPPLEMENTAL_RECORD_UI":"C005522"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":35,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"N05BA22","allCodes":["N05BA22"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cloxazolazepam, also known as Cloxazolam, is a small molecule drug that targets the Aldo-keto reductase family 1 member C3. It belongs to the cloxazolam drug class and is not FDA-approved for any indications. The commercial status of Cloxazolazepam is unknown, and it is not clear if it is patented or available as a generic medication. Further research is needed to determine its safety and efficacy. As a result, it is not currently used in clinical practice.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":true,"trials":false,"score":2}}