{"id":"clotrimazole-vaginal-tablets-lactobacillus","safety":{"commonSideEffects":[{"rate":null,"effect":"Vulvovaginal irritation or burning"},{"rate":null,"effect":"Vaginal discharge changes"},{"rate":null,"effect":"Local allergic reaction"}]},"_chembl":{"chemblId":"CHEMBL104","moleculeType":"Small molecule","molecularWeight":"344.85"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clotrimazole is an azole antifungal that disrupts fungal cell membrane synthesis by inhibiting lanosterol 14α-demethylase, effectively killing Candida species. Lactobacillus probiotics restore the normal acidic vaginal environment and competitive flora, reducing recurrence of yeast infections and supporting vaginal health.","oneSentence":"Clotrimazole kills vaginal fungi while Lactobacillus restores healthy vaginal microbiota to treat and prevent vaginal yeast infections.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:30:24.002Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Vaginal candidiasis (yeast infection)"},{"name":"Prevention of recurrent vulvovaginal candidiasis"}]},"trialDetails":[{"nctId":"NCT04699240","phase":"PHASE4","title":"Study of Lactobacillus in Adjuvant Treatment of RVVC","status":"COMPLETED","sponsor":"Peking University Shenzhen Hospital","startDate":"2020-07-01","conditions":"Recurrent Vulvovaginal Candidiasis","enrollment":140}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Clotrimazole vaginal tablets+ Lactobacillus（Umeta-mimi）"],"phase":"marketed","status":"active","brandName":"Clotrimazole vaginal tablets+ Lactobacillus","genericName":"Clotrimazole vaginal tablets+ Lactobacillus","companyName":"Peking University Shenzhen Hospital","companyId":"peking-university-shenzhen-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Clotrimazole kills vaginal fungi while Lactobacillus restores healthy vaginal microbiota to treat and prevent vaginal yeast infections. Used for Vaginal candidiasis (yeast infection), Prevention of recurrent vulvovaginal candidiasis.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}