{"id":"clotrimazole-vaginal-tablets","safety":{"commonSideEffects":[{"rate":null,"effect":"Vaginal irritation or burning"},{"rate":null,"effect":"Vulvar irritation"},{"rate":null,"effect":"Abdominal cramping"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clotrimazole is an imidazole antifungal that inhibits the fungal cytochrome P450 enzyme lanosterol 14α-demethylase, blocking the conversion of lanosterol to ergosterol. This disrupts the structural integrity of the fungal cell membrane, causing leakage of cellular contents and fungal cell death. It is effective against a broad spectrum of fungi and is commonly used topically for vaginal candidiasis.","oneSentence":"Clotrimazole disrupts fungal cell membrane integrity by inhibiting ergosterol synthesis, leading to cell death.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:40:20.214Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Vulvovaginal candidiasis"}]},"trialDetails":[{"nctId":"NCT04699240","phase":"PHASE4","title":"Study of Lactobacillus in Adjuvant Treatment of RVVC","status":"COMPLETED","sponsor":"Peking University Shenzhen Hospital","startDate":"2020-07-01","conditions":"Recurrent Vulvovaginal Candidiasis","enrollment":140},{"nctId":"NCT06835361","phase":"PHASE2, PHASE3","title":"Efficacy and Safety of Clotrimazole+Lactulose Vaginal Suppositories Vs. Clotrimazole Monotherapy in Adult Women with Candidal Vaginitis/Vulvovaginitis","status":"RECRUITING","sponsor":"AVVA Pharmaceuticals Ltd.","startDate":"2024-02-29","conditions":"Candidal Vulvovaginitis (ICD-10 Code: B37.3), Vulvovaginal Candidiasis (VVC)","enrollment":264},{"nctId":"NCT06349122","phase":"PHASE4","title":"Screen-and-treat Strategy for Vaginal Flora Abnormalities in Pregnant Women at High Risk of Preterm Birth","status":"NOT_YET_RECRUITING","sponsor":"Assistance Publique Hopitaux De Marseille","startDate":"2024-08","conditions":"Bacterial Vaginosis, Vaginal Dysbiosis, Premature Delivery","enrollment":1292},{"nctId":"NCT04292704","phase":"NA","title":"A Protocol for the Role of Fractional CO2 Laser in Consolidation Treatment of Recurrent Vulvovaginal Candidiasis","status":"UNKNOWN","sponsor":"Second Affiliated Hospital of Wenzhou Medical University","startDate":"2019-12-13","conditions":"Vulvovaginal Candidiasis, Genital, Laser Therapy","enrollment":205},{"nctId":"NCT02907307","phase":"PHASE3","title":"Efficacy, Safety LactiSal 1% Gel, LactSal 50 mg, Clotrimazole 100 mg Tablet in Treatment Vulvovaginal Candidiasis","status":"WITHDRAWN","sponsor":"Medinova AG","startDate":"2018-12","conditions":"Vulvovaginal Candidiasis","enrollment":""},{"nctId":"NCT02180828","phase":"PHASE4","title":"Clotrimazole Vaginal Tablet vs Fluconazole for Severe Vulvovaginal Candidiasis","status":"COMPLETED","sponsor":"Peking University Shenzhen Hospital","startDate":"2014-07","conditions":"Candidiasis, Vulvovaginal","enrollment":240},{"nctId":"NCT02242695","phase":"PHASE4","title":"Comparative Efficacy Study of 10 mg Dequalinium Chloride (Fluomizin) in the Treatment of Vulvovaginal Candidiasis","status":"COMPLETED","sponsor":"Medinova AG","startDate":"2014-11","conditions":"Vulvovaginal Candidiasis","enrollment":150},{"nctId":"NCT00755053","phase":"PHASE3","title":"Comparative Efficacy of Ovule vs Tablet","status":"COMPLETED","sponsor":"Bayer","startDate":"2008-09","conditions":"Clotrimazole, Ovulen, Vulvovaginal Candidiasis","enrollment":466},{"nctId":"NCT01697826","phase":"PHASE4","title":"Comparison of Two Topical Formulations Containing Clindamycin and Clotrimazole in Patients With Vaginal Infections","status":"COMPLETED","sponsor":"Dr Bharti Daswani","startDate":"2011-04","conditions":"Vaginal Infections","enrollment":73}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":33,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["clotrimazole vaginal tablets（Bayer）"],"phase":"marketed","status":"active","brandName":"clotrimazole vaginal tablets","genericName":"clotrimazole vaginal tablets","companyName":"Peking University Shenzhen Hospital","companyId":"peking-university-shenzhen-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Clotrimazole disrupts fungal cell membrane integrity by inhibiting ergosterol synthesis, leading to cell death. Used for Vulvovaginal candidiasis.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}