{"id":"clotrimazole-troches","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Abdominal discomfort"},{"rate":null,"effect":"Altered taste"},{"rate":null,"effect":"Local irritation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Clotrimazole is an azole antifungal that inhibits the cytochrome P450-dependent enzyme lanosterol 14α-demethylase, which is essential for ergosterol synthesis in fungal cell membranes. By depleting ergosterol and allowing toxic sterol precursors to accumulate, the drug compromises membrane integrity and fungal cell viability. The troche formulation delivers the drug topically to oral and pharyngeal tissues for local antifungal effect.","oneSentence":"Clotrimazole troches work by inhibiting fungal ergosterol synthesis, disrupting the fungal cell membrane and causing cell death.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T02:31:21.412Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Oral candidiasis (oropharyngeal thrush)"},{"name":"Oral fungal infections"}]},"trialDetails":[{"nctId":"NCT00000676","phase":"PHASE3","title":"Randomized Comparative Study of Fluconazole Versus Clotrimazole Troches in the Prevention of Serious Fungal Infection in Patients With AIDS or Advanced AIDS-Related Complex. (A Nested Study of ACTG 081)","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"Candidiasis, Mycoses, HIV Infections","enrollment":500},{"nctId":"NCT00835029","phase":"PHASE2","title":"Efficacy of Slow Release Clotrimazole Varnish Treating Denture Stomatitis Comparing to Traditional Treatment of Troches","status":"COMPLETED","sponsor":"Hadassah Medical Organization","startDate":"2009-03","conditions":"Oral Candidiasis, Denture Stomatitis","enrollment":13},{"nctId":"NCT02184351","phase":"PHASE3","title":"Clotrimazole vs. Mycelex® in Patients With Human Insufficiency Virus (HIV) Infection for the Treatment of Oropharyngeal Candidiasis","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"2001-05","conditions":"Candidiasis, Oral","enrollment":187},{"nctId":"NCT00390780","phase":"PHASE3","title":"Efficacy and Safety Study of Miconazole Lauriad to Treat Oropharyngeal Candidiasis in HIV Patients","status":"COMPLETED","sponsor":"Valerio Therapeutics","startDate":"2006-07","conditions":"HIV Infections","enrollment":578},{"nctId":"NCT00002282","phase":"NA","title":"A Comparison of the Safety and Effectiveness of Fluconazole or Clotrimazole in the Treatment of Fungal Infections of the Mouth and Throat in Patients With AIDS","status":"COMPLETED","sponsor":"Pfizer","startDate":"","conditions":"Candidiasis, Oral, HIV Infections","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":35,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Oralten"],"phase":"phase_2","status":"active","brandName":"Clotrimazole troches","genericName":"Clotrimazole troches","companyName":"Hadassah Medical Organization","companyId":"hadassah-medical-organization","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Clotrimazole troches are used to treat conditions such as oral candidiasis, mycoses, and HIV infections, as indicated by ClinicalTrials.gov. They work by inhibiting the enzyme lanosterol 14-alpha demethylase, specifically through the inhibition of cytochrome P450 51, as verified by ChEMBL.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}