{"id":"clotrimazole-troche","safety":{"commonSideEffects":[{"rate":null,"effect":"Oral irritation or burning"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Unpleasant taste"},{"rate":null,"effect":"Gastrointestinal upset"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clotrimazole is an azole antifungal that selectively inhibits the cytochrome P450-dependent enzyme lanosterol 14α-demethylase in fungi. This blocks the conversion of lanosterol to ergosterol, a critical component of the fungal cell membrane. The resulting depletion of ergosterol and accumulation of toxic sterol precursors leads to increased membrane permeability and fungal cell lysis.","oneSentence":"Clotrimazole inhibits fungal cell membrane ergosterol synthesis by blocking lanosterol 14α-demethylase, disrupting membrane integrity and causing fungal cell death.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:43:43.917Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Oropharyngeal candidiasis (oral thrush)"}]},"trialDetails":[{"nctId":"NCT05916729","phase":"PHASE4","title":"Use of Maqui Berry Extract in Treating Oral Candidiasis in Diabetes Mellitus Patients and Systemically Healthy Persons","status":"UNKNOWN","sponsor":"University of Belgrade","startDate":"2021-05-01","conditions":"Oral Candidiases","enrollment":90},{"nctId":"NCT00629122","phase":"PHASE4","title":"Pharmacokinetics of Sublingual Versus Oral Tacrolimus in Patients Awaiting Kidney Transplantation","status":"COMPLETED","sponsor":"Weill Medical College of Cornell University","startDate":"2008-02","conditions":"Kidney Failure, Chronic","enrollment":5},{"nctId":"NCT02635438","phase":"PHASE3","title":"A Comparative Clinical Trial to Evaluate the Safety and Clinical Equivalence of Clotrimazole Troche/Lozenges USP, 10mg (Unique Pharmaceutical Laboratories, India) With Clotrimazole Troche 10mg (Roxane Laboratories Inc., USA) in Subjects With Oropharyngeal Candidiasis.","status":"UNKNOWN","sponsor":"Thinq Pharma-CRO Pte. Ltd.","startDate":"2016-12","conditions":"Oropharyngeal Candidiasis","enrollment":360},{"nctId":"NCT00835029","phase":"PHASE2","title":"Efficacy of Slow Release Clotrimazole Varnish Treating Denture Stomatitis Comparing to Traditional Treatment of Troches","status":"COMPLETED","sponsor":"Hadassah Medical Organization","startDate":"2009-03","conditions":"Oral Candidiasis, Denture Stomatitis","enrollment":13},{"nctId":"NCT02184351","phase":"PHASE3","title":"Clotrimazole vs. Mycelex® in Patients With Human Insufficiency Virus (HIV) Infection for the Treatment of Oropharyngeal Candidiasis","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"2001-05","conditions":"Candidiasis, Oral","enrollment":187},{"nctId":"NCT01049633","phase":"","title":"B-Lymphocyte Immunotherapy in Islet Transplantation for Initial Islet Graft Failure","status":"NO_LONGER_AVAILABLE","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"Type 1 Diabetes Mellitus","enrollment":""}],"_emaApprovals":[],"_faersSignals":[{"count":8,"reaction":"DRY MOUTH"},{"count":5,"reaction":"DIZZINESS"},{"count":5,"reaction":"NAUSEA"},{"count":4,"reaction":"DRUG INEFFECTIVE"},{"count":4,"reaction":"HYPOTENSION"},{"count":4,"reaction":"MUSCLE SPASMS"},{"count":4,"reaction":"OFF LABEL USE"},{"count":4,"reaction":"PRURITUS"},{"count":3,"reaction":"ABDOMINAL PAIN"},{"count":3,"reaction":"BACK PAIN"}],"_approvalHistory":[],"publicationCount":9,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Mycelex"],"phase":"marketed","status":"active","brandName":"Clotrimazole Troche","genericName":"Clotrimazole Troche","companyName":"Weill Medical College of Cornell University","companyId":"weill-medical-college-of-cornell-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Clotrimazole inhibits fungal cell membrane ergosterol synthesis by blocking lanosterol 14α-demethylase, disrupting membrane integrity and causing fungal cell death. Used for Oropharyngeal candidiasis (oral thrush).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}