{"id":"clotrimazole-1","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation, burning, or stinging at application site"},{"rate":null,"effect":"Erythema or pruritus"},{"rate":null,"effect":"Allergic contact dermatitis"}]},"_chembl":{"chemblId":"CHEMBL104","moleculeType":"Small molecule","molecularWeight":"344.85"},"_dailymed":{"setId":"4c43e62b-9060-8962-e063-6394a90aff63","title":"ROYCEDERM ANTIFUNGAL .SOAP. (CLOTRIMAZOLE 1%) SOAP [ROYCEDERM LLC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clotrimazole is an imidazole antifungal that disrupts the synthesis of ergosterol, a critical component of fungal cell membranes. By inhibiting the fungal enzyme lanosterol 14α-demethylase (a cytochrome P450 enzyme), it causes accumulation of toxic sterol precursors and membrane instability, leading to fungal cell death. This mechanism is selective for fungal cells over human cells due to structural differences in sterol synthesis pathways.","oneSentence":"Clotrimazole inhibits fungal cell membrane synthesis by blocking the conversion of lanosterol to ergosterol via inhibition of fungal cytochrome P450 enzymes.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:30:24.707Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical fungal infections (dermatophytes, Candida, Malassezia)"},{"name":"Vaginal candidiasis"},{"name":"Oropharyngeal candidiasis"}]},"trialDetails":[{"nctId":"NCT05421858","phase":"PHASE3","title":"A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Participants With Candidemia and/or Invasive Candidiasis.","status":"RECRUITING","sponsor":"Basilea Pharmaceutica","startDate":"2024-12-11","conditions":"Candidemia, Candidiasis, Invasive","enrollment":450},{"nctId":"NCT07155226","phase":"PHASE1, PHASE2","title":"Study of AZD3632 Monotherapy or in Combination With Anticancer Agents in Participants With Advanced Haematologic Malignancies With KMT2Ar, NPM1m, or Other Genotypes Associated With HOX Overexpression","status":"RECRUITING","sponsor":"AstraZeneca","startDate":"2026-01-09","conditions":"Acute Lymphoblastic Leukaemia, Acute Myeloid Leukaemia, Higher-risk Myelodysplastic Syndromes","enrollment":84},{"nctId":"NCT03226418","phase":"PHASE2","title":"Geriatric Assessment & Genetic Profiling to Personalize Therapy in Older Adults With Acute Myeloid Leukemia","status":"COMPLETED","sponsor":"University of Nebraska","startDate":"2017-07-07","conditions":"Adult Acute Myeloid Leukemia, Secondary Acute Myeloid Leukemia, Therapy-Related Acute Myeloid Leukemia","enrollment":75},{"nctId":"NCT07441005","phase":"EARLY_PHASE1","title":"Comparative Efficacy of Topical Oxiconazole Cream (1%) Versus Topical Clotrimazole Cream (1%) in the Treatment of Tinea CrurisAbstract","status":"COMPLETED","sponsor":"Hayat Abad Medical Complex, Peshawar","startDate":"2025-05-15","conditions":"Tinea Cruris","enrollment":386},{"nctId":"NCT07215273","phase":"PHASE2","title":"Study of EL219 vs Standard of Care for Early Antifungal Therapy of Suspected Invasive Mould Infections","status":"RECRUITING","sponsor":"Elion Therapeutics, Inc.","startDate":"2026-02","conditions":"Suspected Invasive Mould Infection","enrollment":80},{"nctId":"NCT07331792","phase":"PHASE1, PHASE2","title":"Comparative Efficacy of Topical 1% Clotrimazole vs Oral Itraconazole in the Treatment of Pityriasis Versicolor","status":"NOT_YET_RECRUITING","sponsor":"Combined Military Hospital Abbottabad","startDate":"2026-02-02","conditions":"Pityriasis Versicolor","enrollment":86},{"nctId":"NCT04869449","phase":"EARLY_PHASE1","title":"Neuro-pharmacological Properties of Repurposed Ketoconazole in Glioblastomas","status":"TERMINATED","sponsor":"Milton S. Hershey Medical Center","startDate":"2022-05-11","conditions":"Glioblastoma, Glioblastoma Multiforme, Glioblastoma Multiforme of Brain","enrollment":1},{"nctId":"NCT07311759","phase":"PHASE3","title":"Safety and Efficacy of Intralesional 0.5% Triamcinolone Acetonide in 0.2% Fluconazole Solution vs 0.1% Topical Mometasone Furoate With 2% Miconazole Nitrate Cream in the Treatment of Chronic Paronychia: An Intraindividual Randomized Controlled Trial.","status":"ACTIVE_NOT_RECRUITING","sponsor":"Cairo University","startDate":"2024-08-17","conditions":"Chronic Paronychia","enrollment":21},{"nctId":"NCT03013998","phase":"PHASE1, PHASE2","title":"Study of Biomarker-Based Treatment of Acute Myeloid Leukemia","status":"RECRUITING","sponsor":"Beat AML, LLC","startDate":"2016-11","conditions":"Previously Untreated Relapsed Refractory Acute Myeloid Leukemia","enrollment":3000},{"nctId":"NCT06274554","phase":"PHASE3","title":"Testing the Role of Anti-fungal Therapy in Improving the Response to Therapies for Crohn's Disease","status":"RECRUITING","sponsor":"Weill Medical College of Cornell University","startDate":"2024-10-04","conditions":"Crohn's Disease, Inflammatory Bowel Diseases","enrollment":120},{"nctId":"NCT00730548","phase":"NA","title":"Compare Remote Patient Management and Standard Care in CRT-D and ICD-patients to Assess the Effect on Heart Failure","status":"COMPLETED","sponsor":"Medtronic Cardiac Rhythm and Heart Failure","startDate":"2007-11","conditions":"Heart Failure, Ventricular Tachycardia, Cardiac Desynchronization","enrollment":180},{"nctId":"NCT00769457","phase":"PHASE4","title":"OptiLink HF Study: Optimization of Heart Failure Management Using Medtronic OptiVol Fluid Status Monitoring and CareLink Network","status":"COMPLETED","sponsor":"Medtronic Cardiac Rhythm and Heart Failure","startDate":"2008-09","conditions":"Heart Failure","enrollment":1002},{"nctId":"NCT04157465","phase":"NA","title":"Anti-fungal Strategies in Acute-on-Chronic Liver Failure Patients","status":"COMPLETED","sponsor":"Post Graduate Institute of Medical Education and Research, Chandigarh","startDate":"2019-11-07","conditions":"Antifungal Agents, Invasive Fungal Infections, Mycoses","enrollment":216},{"nctId":"NCT05534529","phase":"PHASE1","title":"Rezafungin Paediatric PK Study in Paediatric Subjects From Birth to <18 Years of Age","status":"TERMINATED","sponsor":"Mundipharma Research Limited","startDate":"2023-09-13","conditions":"Invasive Fungal Infections","enrollment":32},{"nctId":"NCT05835479","phase":"PHASE2","title":"Rezafungin for Treatment of Pneumocystis Pneumonia in HIV Adults","status":"RECRUITING","sponsor":"Mundipharma Research Limited","startDate":"2023-11-14","conditions":"Pneumocystis Pneumonia","enrollment":50},{"nctId":"NCT05947175","phase":"NA","title":"Vertebral Bone Marrow Clot for Spinal Surgery","status":"RECRUITING","sponsor":"Istituto Ortopedico Rizzoli","startDate":"2023-05-19","conditions":"Degenerative Spine Diseases","enrollment":96},{"nctId":"NCT06869681","phase":"PHASE4","title":"Efficacy of Tropical Sertaconazole Nitrate 2% Vs Clotrimazole 1% for Tinea Pedis","status":"NOT_YET_RECRUITING","sponsor":"Jinnah Postgraduate Medical Centre","startDate":"2025-03-01","conditions":"Tinea Pedis","enrollment":100},{"nctId":"NCT06835361","phase":"PHASE2, PHASE3","title":"Efficacy and Safety of Clotrimazole+Lactulose Vaginal Suppositories Vs. Clotrimazole Monotherapy in Adult Women with Candidal Vaginitis/Vulvovaginitis","status":"RECRUITING","sponsor":"AVVA Pharmaceuticals Ltd.","startDate":"2024-02-29","conditions":"Candidal Vulvovaginitis (ICD-10 Code: B37.3), Vulvovaginal Candidiasis (VVC)","enrollment":264},{"nctId":"NCT06828458","phase":"","title":"Determining Elements of Anti-Fungal Immunity in BURN Patients","status":"NOT_YET_RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2025-03-01","conditions":"Burn","enrollment":327},{"nctId":"NCT06681090","phase":"PHASE1","title":"Different Treatment Modalities for Oral Lichen Plan","status":"COMPLETED","sponsor":"Al-Azhar University","startDate":"2023-03-03","conditions":"Oral Lichen Planus","enrollment":20},{"nctId":"NCT05660382","phase":"PHASE3","title":"Phase III Efficacy and Safety Study of Miconazole Oil for Otomycosis","status":"RECRUITING","sponsor":"Hill Dermaceuticals, Inc.","startDate":"2023-03-02","conditions":"Otomycosis","enrollment":100},{"nctId":"NCT04847050","phase":"PHASE2","title":"A Trial of the Safety and Immunogenicity of the COVID-19 Vaccine (mRNA-1273) in Participants With Hematologic Malignancies and Various Regimens of Immunosuppression, and in Participants With Solid Tumors on PD1/PDL1 Inhibitor Therapy","status":"COMPLETED","sponsor":"National Cancer Institute (NCI)","startDate":"2021-04-28","conditions":"Solid Tumor Malignancy, Hematologic Malignancy, Leukemia","enrollment":19},{"nctId":"NCT06146504","phase":"NA","title":"Clinical Study to Evaluate the Efficacy of an Anti-Fungal Supplement","status":"COMPLETED","sponsor":"CanXida","startDate":"2023-11-30","conditions":"Candida Systemic, Candida Albicans Infection, Candida Infection","enrollment":60},{"nctId":"NCT03583164","phase":"PHASE2","title":"Evaluate F901318 (Olorofim) Treatment of Invasive Fungal Infections in Participants Lacking Treatment Options","status":"COMPLETED","sponsor":"F2G Biotech GmbH","startDate":"2018-06-06","conditions":"Invasive Fungal Infections","enrollment":203},{"nctId":"NCT06349122","phase":"PHASE4","title":"Screen-and-treat Strategy for Vaginal Flora Abnormalities in Pregnant Women at High Risk of Preterm Birth","status":"NOT_YET_RECRUITING","sponsor":"Assistance Publique Hopitaux De Marseille","startDate":"2024-08","conditions":"Bacterial Vaginosis, Vaginal Dysbiosis, Premature Delivery","enrollment":1292},{"nctId":"NCT06339294","phase":"PHASE1","title":"Efficacy of Pyodine Soaked Gelfoam vs Single Topical Application of Clotrimazole in Otomycosis Treatment","status":"COMPLETED","sponsor":"Rawalpindi Medical College","startDate":"2023-06-16","conditions":"Otomycosis","enrollment":90},{"nctId":"NCT06214273","phase":"PHASE2","title":"Low Level Diode Laser Versus Topical Chamomile in Management of Chemotherapy Induced Oral Mucositis","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2024-04","conditions":"Chemotherapy Induced Oral Mucositis","enrollment":45},{"nctId":"NCT04432376","phase":"PHASE2, PHASE3","title":"Efficacy and Safety Study of Miconazole Oil Versus Vehicle on Fungal Infection of the Ear Canal (Otomycosis)","status":"COMPLETED","sponsor":"Hill Dermaceuticals, Inc.","startDate":"2020-07-08","conditions":"Otomycosis","enrollment":382},{"nctId":"NCT04888741","phase":"PHASE2","title":"Methods of T Cell Depletion Trial (MoTD)","status":"UNKNOWN","sponsor":"University of Birmingham","startDate":"2021-02-22","conditions":"Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myelomonocytic Leukemia","enrollment":400},{"nctId":"NCT05951361","phase":"NA","title":"Evaluation of Diode Laser and Topical Steroid Therapy in the Treatment of Erosive Oral Lichen Planus","status":"COMPLETED","sponsor":"Alexandria University","startDate":"2022-02-01","conditions":"Erosive Oral Lichen Planus","enrollment":44},{"nctId":"NCT05916729","phase":"PHASE4","title":"Use of Maqui Berry Extract in Treating Oral Candidiasis in Diabetes Mellitus Patients and Systemically Healthy Persons","status":"UNKNOWN","sponsor":"University of Belgrade","startDate":"2021-05-01","conditions":"Oral Candidiases","enrollment":90},{"nctId":"NCT05882864","phase":"PHASE4","title":"Efficacy of Ginger Muco-bioadhesive Gel in Management of Oral Lichen Planus With Immunohistochemical Analysis","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2023-08-01","conditions":"Oral Lichen Planus","enrollment":28},{"nctId":"NCT03896880","phase":"","title":"Detection of Bloodstream Pathogens in Hematological Malignancies","status":"COMPLETED","sponsor":"Assiut University","startDate":"2020-01-01","conditions":"Bloodstream Infection","enrollment":139},{"nctId":"NCT00061282","phase":"PHASE1, PHASE2","title":"Clotrimazole Enemas for Pouchitis in Children and Adults","status":"TERMINATED","sponsor":"Web","startDate":"2002-09-30","conditions":"Ulcerative Colitis, Pouchitis, Ileitis","enrollment":11},{"nctId":"NCT01244256","phase":"PHASE2, PHASE3","title":"Efficacy and Comparative of the Association Beclomethasone Clotrimzaol + Gentamicin in Patients With Acne Contaminated","status":"SUSPENDED","sponsor":"Azidus Brasil","startDate":"2007-04","conditions":"Folliculitis","enrollment":80},{"nctId":"NCT03130738","phase":"PHASE2","title":"Dose-Ranging Study for Miconazole Oil for Treatment of Otomycosis","status":"COMPLETED","sponsor":"Hill Dermaceuticals, Inc.","startDate":"2017-04-20","conditions":"Otomycosis","enrollment":65},{"nctId":"NCT01668849","phase":"PHASE1","title":"Edible Plant Exosome Ability to Prevent Oral Mucositis Associated With Chemoradiation Treatment of Head and Neck Cancer","status":"COMPLETED","sponsor":"University of Louisville","startDate":"2012-08-02","conditions":"Head and Neck Cancer, Oral Mucositis","enrollment":60},{"nctId":"NCT03599323","phase":"","title":"Study on the Safety of the Approved Product Empedic L Cream During Its Routine Use (Active Ingredient is Clotrimazole 1%)","status":"COMPLETED","sponsor":"Bayer","startDate":"2018-07-10","conditions":"Vaginal Candida","enrollment":1033},{"nctId":"NCT04813822","phase":"PHASE2","title":"Study Evaluating the Efficacy and Safety of Miconazole Nitrate + Domiphen Bromide Vaginal Cream in the Treatment of Subjects With Acute Vulvovaginal Candidiasis","status":"UNKNOWN","sponsor":"Aesculape CRO Belgium BV","startDate":"2021-09-13","conditions":"Acute Vulvovaginal Candidiasis","enrollment":90},{"nctId":"NCT00671528","phase":"PHASE4","title":"Safety and Efficacy of Quadriderme® in the Treatment of Impetiginous Eczema (Study P05134AM4)","status":"TERMINATED","sponsor":"Organon and Co","startDate":"2009-07","conditions":"Dermatitis, Atopic, Eczema, Atopic, Skin Diseases, Eczematous","enrollment":3},{"nctId":"NCT04947592","phase":"","title":"SD-OCT Guided Treatment of Fungal Chorioretinitis","status":"UNKNOWN","sponsor":"Benha University","startDate":"2020-01-15","conditions":"Fungal Retinitis","enrollment":10},{"nctId":"NCT05129033","phase":"NA","title":"A Prospective Study on Optimizing Treatment for ABPA","status":"UNKNOWN","sponsor":"Shanghai Zhongshan Hospital","startDate":"2021-11-15","conditions":"Allergic Bronchopulmonary Aspergillosis","enrollment":100},{"nctId":"NCT00000676","phase":"PHASE3","title":"Randomized Comparative Study of Fluconazole Versus Clotrimazole Troches in the Prevention of Serious Fungal Infection in Patients With AIDS or Advanced AIDS-Related Complex. (A Nested Study of ACTG 081)","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"Candidiasis, Mycoses, HIV Infections","enrollment":500},{"nctId":"NCT02582177","phase":"PHASE3","title":"Effectiveness Study of Ketoconazole and Betamethasone to Treat Fungal Infection and Dermatophytosis","status":"COMPLETED","sponsor":"Ache Laboratorios Farmaceuticos S.A.","startDate":"2019-06-11","conditions":"Tinea","enrollment":125},{"nctId":"NCT04824261","phase":"NA","title":"Effectiveness of 4% Boric Acid in Distilled Water Versus Clotrimazole Solution in Otomycosis Patients.","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2021-06-01","conditions":"Otomycosis","enrollment":100},{"nctId":"NCT00385502","phase":"PHASE2","title":"A Trial of the Safety and Efficacy of EcoNail™ in the Treatment of Fungus Infections of the Great Toenail","status":"COMPLETED","sponsor":"Abeona Therapeutics, Inc","startDate":"2006-09","conditions":"Onychomycosis","enrollment":40},{"nctId":"NCT04442633","phase":"NA","title":"Glutamine With Topical Corticosteroids for Lichen Planus Treatment","status":"COMPLETED","sponsor":"Hams Hamed Abdelrahman","startDate":"2019-04-01","conditions":"Lichen Penis Planus","enrollment":30},{"nctId":"NCT03005353","phase":"PHASE2, PHASE3","title":"Treatment of Candidal Vulvovaginitis Using Cumin Seed Extract Vaginal Suppositories.","status":"COMPLETED","sponsor":"Assiut University","startDate":"2018-03-01","conditions":"Infection, Fungal","enrollment":100},{"nctId":"NCT04341402","phase":"PHASE2","title":"Systemic Uptake of Diclofenac Sodium in Combination With Miconazole as Antifungal Nail Gel When Applied Daily With Monitoring of Hepatic and Renal Enzymes, and Serum Levels of Diclofenac 12 Hours After Application, and at 3 and 6 Months Study","status":"UNKNOWN","sponsor":"William N Handelman","startDate":"2020-05-01","conditions":"Tinea Unguium, Onychomycosis","enrollment":30},{"nctId":"NCT04292704","phase":"NA","title":"A Protocol for the Role of Fractional CO2 Laser in Consolidation Treatment of Recurrent Vulvovaginal Candidiasis","status":"UNKNOWN","sponsor":"Second Affiliated Hospital of Wenzhou Medical University","startDate":"2019-12-13","conditions":"Vulvovaginal Candidiasis, Genital, Laser Therapy","enrollment":205},{"nctId":"NCT02860845","phase":"PHASE4","title":"Use of Boric Acid in Combination With Probiotics for the Treatment of Vaginal Infections","status":"COMPLETED","sponsor":"Laboratorios Ordesa","startDate":"2016-07-12","conditions":"Candidiasis, Vaginosis, Bacterial","enrollment":48},{"nctId":"NCT00629122","phase":"PHASE4","title":"Pharmacokinetics of Sublingual Versus Oral Tacrolimus in Patients Awaiting Kidney Transplantation","status":"COMPLETED","sponsor":"Weill Medical College of Cornell University","startDate":"2008-02","conditions":"Kidney Failure, Chronic","enrollment":5},{"nctId":"NCT03115073","phase":"PHASE2, PHASE3","title":"ProF-001_Phase IIa","status":"COMPLETED","sponsor":"ProFem GmbH","startDate":"2017-04-04","conditions":"Vulvovaginal Candidiasis (VVC)","enrollment":84},{"nctId":"NCT02907307","phase":"PHASE3","title":"Efficacy, Safety LactiSal 1% Gel, LactSal 50 mg, Clotrimazole 100 mg Tablet in Treatment Vulvovaginal Candidiasis","status":"WITHDRAWN","sponsor":"Medinova AG","startDate":"2018-12","conditions":"Vulvovaginal Candidiasis","enrollment":""},{"nctId":"NCT03296436","phase":"EARLY_PHASE1","title":"A Pilot Study to Assess the Efficacy of NEOX® CORD 1K® in the Treatment of Complex Diabetic Wounds","status":"WITHDRAWN","sponsor":"Johns Hopkins University","startDate":"2020-01","conditions":"Vascular Ulcer (Arterial or Venous Including Diabetic Ulcers Not Located on the Foot), Diabetic Foot Ulcer, Diabetic Foot","enrollment":""},{"nctId":"NCT02515656","phase":"PHASE3","title":"Assessment of the Efficacy of POLYGYNAX® in the Empirical Treatment of Infectious Vaginitis","status":"COMPLETED","sponsor":"Laboratoire Innotech International","startDate":"2015-09","conditions":"Vaginitis","enrollment":661},{"nctId":"NCT03760276","phase":"PHASE1","title":"A Study to Evaluate the Appropriateness of the Voriconazole Dosing Regimen","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2018-08-20","conditions":"Fungal Infection","enrollment":11},{"nctId":"NCT02621905","phase":"PHASE4","title":"Steady-State Comparative Bioavailability Study in Prophylaxis Patients of Lozanoc® 50 mg With Sporanox® 100 mg","status":"COMPLETED","sponsor":"Mayne Pharma International Pty Ltd","startDate":"2015-11","conditions":"Neutropenia","enrollment":40},{"nctId":"NCT03024502","phase":"PHASE1, PHASE2","title":"Patients With Vulvovaginal Candidiasis","status":"UNKNOWN","sponsor":"University of Sao Paulo","startDate":"2018-01-30","conditions":"Vulvovaginal Candidiasis","enrollment":90},{"nctId":"NCT00361517","phase":"PHASE3","title":"To Determine Whether Galactomannan Test Will Help to Detect Fungal Infections Early and Hence Start Treatment Early","status":"COMPLETED","sponsor":"Singapore General Hospital","startDate":"2006-06-01","conditions":"Aspergillosis","enrollment":47},{"nctId":"NCT03117439","phase":"NA","title":"Beta-Glucan Driven vs. Empirical Antifungal Therapy in Critically Ill Patients","status":"COMPLETED","sponsor":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","startDate":"2016-07","conditions":"Antifungal Agents","enrollment":120},{"nctId":"NCT03632733","phase":"PHASE2","title":"Effects of Antimicrobials on the Altered Skin Flora in Arsenical Keratosis","status":"UNKNOWN","sponsor":"Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh","startDate":"2018-01-21","conditions":"Keratotic Nodular Size","enrollment":30},{"nctId":"NCT03572959","phase":"PHASE4","title":"Management of Pain in Oral Lichen Planus","status":"COMPLETED","sponsor":"Sherine Adel Nasry","startDate":"2016-12-27","conditions":"Oral Lichen Planus","enrollment":24},{"nctId":"NCT00078559","phase":"PHASE1, PHASE2","title":"Combination Immunosuppressive Therapy to Prevent Kidney Transplant Rejection in Adults","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2003-11","conditions":"Kidney Transplantation, Kidney Disease","enrollment":10},{"nctId":"NCT02057289","phase":"PHASE1","title":"A Pharmacokinetic Study of Pediatric Micafungin Prophylaxis","status":"TERMINATED","sponsor":"Children's Hospital Medical Center, Cincinnati","startDate":"2014-01","conditions":"Immunocompromised, Bone Marrow Transplant, Cancer","enrollment":9},{"nctId":"NCT02905994","phase":"PHASE1","title":"Volasertib Combined With Induction Chemotherapy in Acute Myeloid Leukemia","status":"WITHDRAWN","sponsor":"Massachusetts General Hospital","startDate":"2016-09","conditions":"AML","enrollment":""},{"nctId":"NCT03026478","phase":"PHASE2","title":"Topical Betamethasone and Clobetasol in Orabase in Oral Lichen Planus","status":"UNKNOWN","sponsor":"Garlapati Komali","startDate":"2016-05-06","conditions":"Oral Lichen Planus","enrollment":30},{"nctId":"NCT03359070","phase":"PHASE2","title":"Clinical Trial Comparing Dapaconazole Versus Miconazole in Patients With Tinea Cruris","status":"COMPLETED","sponsor":"Galeno Desenvolvimento de Pesquisas Clínicas","startDate":"2014-01-29","conditions":"Tinea Cruris","enrollment":51},{"nctId":"NCT01731574","phase":"PHASE1","title":"DDI Potential: Dapivirine Vaginal Ring and Miconazole Nitrate","status":"COMPLETED","sponsor":"International Partnership for Microbicides, Inc.","startDate":"2012-12","conditions":"HIV","enrollment":36},{"nctId":"NCT02847286","phase":"PHASE1","title":"To Assess the Drug-drug Interaction Potential Between Dapivirine Vaginal Ring-004, Containing 25 mg of Dapivirine, and Clotrimazole 10 mg/g (1%)","status":"COMPLETED","sponsor":"International Partnership for Microbicides, Inc.","startDate":"2015-09-01","conditions":"HIV- Prevention","enrollment":36},{"nctId":"NCT02215395","phase":"PHASE1","title":"An Open-label Study to Evaluate the Effects of Concurrent Administration of Vaginal Antimycotic Medication Miconazole Nitrate on the Pharmacokinetics of Nestorone and Ethinyl Estradiol Delivered by a Contraceptive Vaginal Ring in Normal Ovulating Women","status":"COMPLETED","sponsor":"Population Council","startDate":"2014-03","conditions":"Antifungal Drug Adverse Reaction","enrollment":45},{"nctId":"NCT02545452","phase":"PHASE1","title":"Effect of Concomitant Use of an Antimycotic, an Antibiotic, a Spermicide or Tampons on Pharmacokinetics of Anastrozole and Levonorgestrel Released From Intra-vaginal Ring","status":"COMPLETED","sponsor":"Bayer","startDate":"2015-09-15","conditions":"Endometriosis","enrollment":52},{"nctId":"NCT01580878","phase":"PHASE1","title":"Evaluate the Safety & Bioequivalence of a Generic Butenafine Cream & Lotrimin Ultra® & Compare Both to a Vehicle Control in Treatment of Interdigital Tinea Pedis","status":"COMPLETED","sponsor":"Sun Pharmaceutical Industries, Inc.","startDate":"2012-01","conditions":"Tinea Pedis","enrollment":707},{"nctId":"NCT02180828","phase":"PHASE4","title":"Clotrimazole Vaginal Tablet vs Fluconazole for Severe Vulvovaginal Candidiasis","status":"COMPLETED","sponsor":"Peking University Shenzhen Hospital","startDate":"2014-07","conditions":"Candidiasis, Vulvovaginal","enrollment":240},{"nctId":"NCT01993823","phase":"PHASE3","title":"Clinical Study to Assess the Efficacy and Safety of G238 Compared to Clotrimazole Otic Solution in the Treatment of Otomycosis","status":"COMPLETED","sponsor":"Salvat","startDate":"2013-05","conditions":"Otomycosis","enrollment":190},{"nctId":"NCT02941068","phase":"PHASE2","title":"the Influence of Prophylactic and Empirical Anti-fungal Treatment in Severe Sepsis Patients With Perforations","status":"COMPLETED","sponsor":"Nanjing PLA General Hospital","startDate":"2012-03","conditions":"Intra-abdominal Perforation","enrollment":223},{"nctId":"NCT02242695","phase":"PHASE4","title":"Comparative Efficacy Study of 10 mg Dequalinium Chloride (Fluomizin) in the Treatment of Vulvovaginal Candidiasis","status":"COMPLETED","sponsor":"Medinova AG","startDate":"2014-11","conditions":"Vulvovaginal Candidiasis","enrollment":150},{"nctId":"NCT01335373","phase":"","title":"Observational Program Neo-Penotran® Forte","status":"COMPLETED","sponsor":"Bayer","startDate":"2010-10","conditions":"Vaginal Candidiasis, Bacterial Vaginosis, Trichomonal Vaginitis","enrollment":13024},{"nctId":"NCT02818803","phase":"PHASE3","title":"Efficacy of Standardized-propolis Extract (EPP-AF®) Gel Formulation as Buccal Antiseptic","status":"COMPLETED","sponsor":"University of Sao Paulo","startDate":"2016-01","conditions":"Candidiasis, Oral, Stomatitis, Denture","enrollment":40},{"nctId":"NCT01501708","phase":"PHASE2","title":"Caspofungin Based Combined Anti-fungal Therapy for Proven or Probable Invasive Fungal Infection","status":"UNKNOWN","sponsor":"Shanghai Jiao Tong University School of Medicine","startDate":"2011-12","conditions":"Leukemia, Transplantation, Hematopoietic Stem Cell","enrollment":55},{"nctId":"NCT02713139","phase":"PHASE3","title":"Efficacy and Safety of the Association of Clotrimazole and Metronidazole in the Treatment of Vaginal Discharge From Different Etiologies.","status":"WITHDRAWN","sponsor":"Ache Laboratorios Farmaceuticos S.A.","startDate":"2013-09","conditions":"Sexual Active Women, Vaginal Discharge","enrollment":""},{"nctId":"NCT00755053","phase":"PHASE3","title":"Comparative Efficacy of Ovule vs Tablet","status":"COMPLETED","sponsor":"Bayer","startDate":"2008-09","conditions":"Clotrimazole, Ovulen, Vulvovaginal Candidiasis","enrollment":466},{"nctId":"NCT02443311","phase":"PHASE4","title":"Clinical and Immunohistochemical Effect of Topical Pimecrolimus in Treatment of Oral Lichen Planus","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2010-09","conditions":"Oral Lichen Planus","enrollment":24},{"nctId":"NCT01547221","phase":"NA","title":"Effectiveness of 3% Boric Acid in 70% Alcohol Versus 1% Clotrimazole Solution in Otomycosis Patients","status":"COMPLETED","sponsor":"Khon Kaen Hospital","startDate":"2012-03","conditions":"Otomycosis","enrollment":120},{"nctId":"NCT00004492","phase":"PHASE1, PHASE2","title":"Phase I/II Randomized Study of Hydroxyurea With or Without Clotrimazole in Patients With Sickle Cell Anemia","status":"COMPLETED","sponsor":"University of North Carolina","startDate":"1999-10","conditions":"Sickle Cell Anemia","enrollment":20},{"nctId":"NCT02248506","phase":"PHASE4","title":"Epidemiological Study About the Evolution of Patients Treated for an Acute Episode of Vulvovaginal Candidiasis","status":"COMPLETED","sponsor":"Instituto Palacios","startDate":"2013-06","conditions":"Candidiasis, Vulvovaginal","enrollment":56},{"nctId":"NCT00835029","phase":"PHASE2","title":"Efficacy of Slow Release Clotrimazole Varnish Treating Denture Stomatitis Comparing to Traditional Treatment of Troches","status":"COMPLETED","sponsor":"Hadassah Medical Organization","startDate":"2009-03","conditions":"Oral Candidiasis, Denture Stomatitis","enrollment":13},{"nctId":"NCT00004404","phase":"NA","title":"Study of Clotrimazole and Hydroxyurea in Patients With Sickle Cell Syndromes","status":"COMPLETED","sponsor":"Boston Children's Hospital","startDate":"1997-04","conditions":"Sickle Cell Anemia","enrollment":20},{"nctId":"NCT02328053","phase":"NA","title":"Clinical & Visual Outcomes of Collagen Cross Linking for Fungal Keratitis","status":"UNKNOWN","sponsor":"Aravind Eye Care System","startDate":"2014-02","conditions":"Mycotic Corneal Ulcer","enrollment":20},{"nctId":"NCT00841971","phase":"PHASE4","title":"Anidulafungin Versus Fluconazole for the Prevention of Fungal Infections in Liver Transplant Recipients","status":"COMPLETED","sponsor":"University of Pittsburgh","startDate":"2010-02","conditions":"Mycoses, Fungemia, Central Nervous System Fungal Infections","enrollment":200},{"nctId":"NCT01661556","phase":"PHASE4","title":"Clinical Trial of Hydroquinone Versus Miconazol in Melasma","status":"UNKNOWN","sponsor":"Universidad Autonoma de San Luis Potosí","startDate":"2011-10","conditions":"Melasma","enrollment":60},{"nctId":"NCT02185456","phase":"EARLY_PHASE1","title":"Validation of a Novel Diagnostic, Prognostic Assay for Bacterial Vaginosis","status":"UNKNOWN","sponsor":"Wayne State University","startDate":"2014-09","conditions":"Bacterial Vaginosis","enrollment":200},{"nctId":"NCT01230814","phase":"PHASE2","title":"Topical Metronidazole and Miconazole Co-formulated Vaginal Suppositories for Preventing Vaginal Infections in HIV-seronegative Women","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2011-04","conditions":"Bacterial Vaginosis, Candidiasis, Trichomoniasis","enrollment":234},{"nctId":"NCT00047827","phase":"PHASE2","title":"Trial of Micafungin (FK463) in Combination With Liposomal Amphotericin B (AmBisome) for Aspergillosis","status":"TERMINATED","sponsor":"Astellas Pharma Inc","startDate":"2002-12","conditions":"Aspergillosis","enrollment":2},{"nctId":"NCT01049633","phase":"","title":"B-Lymphocyte Immunotherapy in Islet Transplantation for Initial Islet Graft Failure","status":"NO_LONGER_AVAILABLE","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"Type 1 Diabetes Mellitus","enrollment":""},{"nctId":"NCT01119742","phase":"PHASE1","title":"Clinical Equivalence of Two Generic Butenafine Hydrochloride 1% Creams as Compared to Lotrimin Ultra Cream in Patients With Interdigital Tinea Pedis","status":"TERMINATED","sponsor":"Sun Pharmaceutical Industries, Inc.","startDate":"2010-07","conditions":"Interdigital Tinea Pedis","enrollment":428},{"nctId":"NCT01110330","phase":"PHASE3","title":"An Efficacy Study of a New Formulation of Ketoconazole 2% Cream in Patients With Tinea Pedis, Commonly Known as Athlete's Foot","status":"TERMINATED","sponsor":"Johnson & Johnson Pharmaceutical Research & Development, L.L.C.","startDate":"2007-07","conditions":"Tinea Pedis","enrollment":583},{"nctId":"NCT00835510","phase":"PHASE1","title":"Clinical Equivalence of Two Butenafine Hydrochloride 1% Creams in Patients With Interdigital Tinea Pedis","status":"COMPLETED","sponsor":"Sun Pharmaceutical Industries, Inc.","startDate":"2008-06","conditions":"Tinea Pedis","enrollment":548},{"nctId":"NCT00390780","phase":"PHASE3","title":"Efficacy and Safety Study of Miconazole Lauriad to Treat Oropharyngeal Candidiasis in HIV Patients","status":"COMPLETED","sponsor":"Valerio Therapeutics","startDate":"2006-07","conditions":"HIV Infections","enrollment":578},{"nctId":"NCT01524432","phase":"PHASE1","title":"Hygienic Socks With Antifungal Agent-loaded Microcapsules for Patients With Tinea Pedis","status":"COMPLETED","sponsor":"Prof. Yuen Chun-Wah","startDate":"2012-01","conditions":"Tinea Pedis","enrollment":42}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":100,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Clotrimazole 1%","genericName":"Clotrimazole 1%","companyName":"Jinnah Postgraduate Medical Centre","companyId":"jinnah-postgraduate-medical-centre","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Clotrimazole inhibits fungal cell membrane synthesis by blocking the conversion of lanosterol to ergosterol via inhibition of fungal cytochrome P450 enzymes. Used for Topical fungal infections (dermatophytes, Candida, Malassezia), Vaginal candidiasis, Oropharyngeal candidiasis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}